This is a list of Jacksonville State Gamecocks football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Player | Team | Position | Notes |
|---|---|---|---|---|---|---|
| 1957 | 14 | 167 | Phil Smith | Detroit Lions | B | |
| 1958 | 28 | 332 | Dean Akin | Pittsburgh Steelers | E | |
| 1960 | 14 | 159 | Jim Glasgow | Detroit Lions | T | |
| 1966 | 11 | 167 | Terry Owens | Chicago Bears | WR | |
| 1971 | 4 | 94 | David Robinson | Kansas City Chiefs | TE | |
| 1979 | 2 | 50 | Jesse Baker | Houston Oilers | DE | |
| 1987 | 9 | 227 | Keith McKeller | Buffalo Bills | TE | |
| 1990 | 2 | 53 | Eric Davis | San Francisco 49ers | DB | |
| 10 | 273 | Orlando Adams | Philadelphia Eagles | DT | ||
| 1991 | 6 | 162 | Darrell Malone | Kansas City Chiefs | DB | |
| 11 | 299 | David Gulledge | Washington Redskins | DB | ||
| 2013 | 6 | 195 | Alan Bonner | Houston Texans | WR | |
| 2018 | 5 | 154 | Siran Neal | Buffalo Bills | DB |