This is a list of Liberty Flames football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Player | Team | Position | Notes |
|---|---|---|---|---|---|---|
| 1985 | 8 | 203 | Fred Banks | Cleveland Browns | WR | |
| 1986 | 4 | 88 | Kelvin Edwards | New Orleans Saints | WR | |
| 1989 | 11 | 292 | Richard Shelton | Denver Broncos | DB | |
| 1990 | 1 | 21 | Eric Green | Pittsburgh Steelers | TE | |
| 10 | 271 | Donald Smith | Minnesota Vikings | DB | ||
| 2009 | 7 | 250 | Rashad Jennings | Jacksonville Jaguars | RB | |
| 2014 | 4 | 125 | Walt Aikens | Miami Dolphins | DB | |
| 2020 | 4 | 142 | Antonio Gandy-Golden | Washington Redskins | WR | |
| 2022 | 3 | 86 | Malik Willis | Tennessee Titans | QB | |
| 2023 | 6 | 210 | Demario Douglas | New England Patriots | WR |