This is a list of Lindenwood Lions players in the NFL Draft .
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| = Pro Bowler | |
| = Hall of Famer |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 2014 | 4 | 27 | 127 | Pierre Desir | Cleveland Browns | DB |
Note: No drafts held before 1936
| Debut year | Player name | Position | Debut NFL/AFL team | Notes |
|---|---|---|---|---|
| 2006 | DeDe Dorsey | RB | Cincinnati Bengals | — |
| 2008 | Brian Schaefering | DE | Cleveland Browns | — |
| 2017 | Connor Harris | ILB | New York Jets | — |
| 2019 | Jonathan Harris | DT | Chicago Bears | — |