This is a list of South Alabama Jaguars football players in the NFL draft .
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| = Pro Bowler | |
| = Hall of Famer |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 2017 | 2 | 13 | 44 | Gerald Everett | Los Angeles Rams | TE |
| 2021 | 7 | 27 | 255 | Kawaan Baker | New Orleans Saints | WR |
| 2022 | 3 | 24 | 88 | Jalen Tolbert | Dallas Cowboys | WR |
| 2023 | 5 | 20 | 155 | Darrell Luter Jr. | San Francisco 49ers | DB |
Note: No drafts held before 1920
| Debut year | Player name | Position | Debut NFL/AFL team | Notes |
|---|---|---|---|---|
| 2011 | Courtney Smith | WR | New York Jets | |
| 2015 | Wes Saxton | TE | New York Jets | |
| 2016 | Braedon Bowman | TE | Jacksonville Jaguars | |
| 2018 | Jeremy Reaves | S | Philadelphia Eagles | Pro Bowl (2022) |
| 2020 | Corliss Waitman | P | Pittsburgh Steelers | |
| 2023 | Jalen Wayne | WR | Buffalo Bills | |
| 2024 | Carter Bradley | QB | Las Vegas Raiders | |
| Lincoln Sefcik | TE | New York Jets | ||
| Jamie Sheriff | LB | Seattle Seahawks | ||
| 2025 | Jamaal Pritchett | WR | New York Jets | |
| DJ Thomas-Jones | TE | Pittsburgh Steelers | ||