This is a list of South Dakota Coyotes football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 1950 | 21 | 8 | 269 | Howard Blumhardt | Chicago Cardinals | B |
| 1954 | 14 | 3 | 160 | Ordell Braase | Baltimore Colts | T |
| 1957 | 25 | 10 | 299 | Carl Johnson | Detroit Lions | B |
| 1958 | 10 | 8 | 117 | Ray Schamber | Baltimore Colts | E |
| 14 | 1 | 158 | Harry Hauffe | Green Bay Packers | T | |
| 25 | 8 | 297 | Wayne Haensel | New York Giants | T | |
| 1970 | 3 | 11 | 63 | John Kohler | Denver Broncos | T |
| 1972 | 9 | 5 | 213 | Gene Macken | St. Louis Cardinals | C |
| 1974 | 10 | 24 | 258 | Johnny Vann | Washington Redskins | DB |
| 1979 | 12 | 15 | 318 | Bill Moats | Green Bay Packers | P |
| 1980 | 10 | 23 | 272 | Ben Long | Miami Dolphins | LB |
| 1982 | 10 | 7 | 258 | Craig Austin | Seattle Seahawks | LB |
| 1986 | 9 | 11 | 232 | Mike Slaton | Minnesota Vikings | DB |
| 11 | 23 | 300 | Chul Schwanke | Los Angeles Rams | RB | |
| 1990 | 10 | 4 | 252 | David Elle | Phoenix Cardinals | TE |
| 2012 | 6 | 23 | 193 | Tom Compton | Washington Redskins | T |
| 2014 | 7 | 40 | 255 | Tyler Starr | Atlanta Falcons | LB |
| 2024 | 7 | 7 | 227 | Myles Harden | Cleveland Browns | DB |
Note: No drafts held before 1920
| Debut year | Player name | Position | Debut NFL/AFL team | Notes |
|---|---|---|---|---|
| 1986 | Rodney Tweet | WR | Atlanta Falcons | — |
| 1999 | Matt Chatham | LB | St. Louis Rams | — |
| 2000 | Jamel White | RB | Indianapolis Colts | — |
| 2001 | Josh Stamer | LB | New York Giants | — |
| 2002 | Filip Filipovic | P | Dallas Cowboys | — |
| 2004 | Dwight Anderson | DB | St. Louis Rams | — |
| Jason Anderson | RB | Houston Texans | — | |
| 2020 | Kameron Cline | DL | Indianapolis Colts | — |
| 2022 | Jack Cochrane | LB | Kansas City Chiefs | — |
| 2023 | Alex Jensen | OT | Miami Dolphins | — |
| 2024 | Brock Mogensen | LB | Dallas Cowboys | — |