This is a list of Illinois State Redbirds football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 1944 | 6 | 2 | 45 | Bruce McDonald | Brooklyn Dodgers | E |
| 22 | 1 | 220 | Jack Esorcia | Chicago Cardinals | B | |
| 1970 | 15 | 21 | 385 | Guy Homoly | Cleveland Browns | DB |
| 1973 | 6 | 10 | 140 | Ron Bell | Pittsburgh Steelers | RB |
| 1976 | 6 | 16 | 172 | Calvin Harper | Kansas City Chiefs | T |
| 1978 | 3 | 6 | 62 | Estus Hood | Green Bay Packers | DB |
| 1984 | 3 | 6 | 62 | Clarence Collins | San Diego Chargers | WR |
| 1985 | 7 | 8 | 176 | Mike Prior | Tampa Bay Buccaneers | DB |
| 1986 | 7 | 1 | 167 | Jim Meyer | Cleveland Browns | T |
| 1990 | 10 | 10 | 258 | Bill Miller | Detroit Lions | WR |
| 2005 | 5 | 2 | 138 | Boomer Grigsby | Kansas City Chiefs | LB |
| 2006 | 5 | 28 | 160 | Brent Hawkins | Jacksonville Jaguars | DE |
| 2007 | 3 | 11 | 75 | Laurent Robinson | Atlanta Falcons | WR |
| 2013 | 6 | 25 | 193 | Nate Palmer | Green Bay Packers | LB |
| 2014 | 7 | 20 | 235 | Shelby Harris | Oakland Raiders | DE |
| 2015 | 5 | 37 | 173 | James O'Shaughnessy | Kansas City Chiefs | TE |
| 2018 | 5 | 16 | 151 | Davontae Harris | Cincinnati Bengals | DB |
Note: No drafts held before 1920