Thomas Burton Hanly, Arkansas state legislator and judge, CSA Congressman, graduated in 1834
Teresa Isaac, mayor of Lexington, Kentucky, 2002–2006
George W. Johnson, Confederate "governor" of Kentucky and Kentucky State Representative, received three degrees from Transylvania University: an A.B. in 1829, an LL.B. in 1832, and an M.A. in 1833
John Breckinridge Castleman, a Confederate officer who later rose to the rank of Brigadier General in the U.S. Army, studied law there immediately before the outbreak of the Civil War
Carl Rogers Darnall, U.S. Brigadier General credited with originating the technique of liquid chlorination of drinking water
Ethelbert Ludlow Dudley, prominent physician and Union military commander in the Civil War, graduated in 1842 and joined the staff of the Medical School
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