| Senator | Lifespan | Party [1] | Prov. | Entered | Left | Appointed by | Left due to | For life? |
|---|---|---|---|---|---|---|---|---|
| Nicole Eaton | 1945–present | C | ON | 2 January 2009 | 21 January 2020 | Harper | Retirement | |
| William Cameron Edwards | 1844–1921 | L | ON | 17 March 1903 | 17 September 1921 | Laurier | Death | Y |
| Art Eggleton | 1943–present | L | ON | 24 March 2005 | 29 September 2018 | Martin | Retirement | |
| John Campbell Elliott | 1872–1941 | L | ON | 29 January 1940 | 20 December 1941 | King | Death | Y |
| John Valentine Ellis | 1835–1913 | L | NB | 3 September 1900 | 10 June 1913 | Laurier | Death | Y |
| Clarence Emerson | 1901–1963 | PC | NB | 12 October 1957 | 25 September 1963 | Diefenbaker | Death | Y |
| Henry Read Emmerson | 1883–1954 | L | NB | 25 June 1949 | 21 June 1954 | St. Laurent | Death | Y |
| Tobias Enverga | 1955–2017 | C | ON | 6 September 2012 | 16 November 2017 | Harper | Death | |
| Raymond Eudes | 1912–1980 | L | QC | 8 April 1968 | 25 October 1980 | Pearson | Death | |
| William Daum Euler | 1875–1961 | L | ON | 11 May 1940 | 15 July 1961 | King | Death | Y |
| Douglas Everett | 1927–2018 | L | MB | 8 November 1966 | 20 January 1994 | Pearson | Resignation | |
| John Ewasew | 1922–1978 | L | QC | 17 December 1976 | 26 March 1978 | Trudeau, P. | Death | |
| Trevor Eyton | 1934–2019 | C | ON | 23 September 1990 | 12 July 2009 | Mulroney | Retirement |