| No. | Secretary of Foreign Affairs | Took office | Left office | President |
|---|
| 1 | José Francisco Pereira Martínez | 24 October 1831 | 3 April 1832 | Francisco de Paula Santander y Omaña |
| 2 | Alejandro Vélez Barrientos | 3 April 1832 | 3 April 1833 |
| 3 | José Rafael Mosquera Hurtado | 3 April 1833 | 1 August 1833 |
| 4 | Lino de Pombo O'Donnell | 1 August 1833 | 14 July 1835 |
| 5 | Francisco Soto Montes de Oca | 14 July 1835 | 4 September 1835 |
| 6 | Lino de Pombo O'Donnell | 4 September 1835 | 23 March 1836 |
| 7 | José Nazario Florentino González Vargas | 23 March 1836 | 3 May 1836 |
| 8 | Lino de Pombo O'Donnell | 3 May 1836 | 15 May 1838 | José Ignacio de Márquez Barreto |
| 9 | Pedro Alcántara Herrán Martínez | 15 May 1838 | 16 July 1839 |
| 10 | Tomás Cipriano de Mosquera y Arboleda | 16 July 1839 | 30 July 1839 |
| 11 | Alejandro Vélez Barrientos | 30 July 1839 | 28 January 1840 |
| 12 | Eusebio Borrero y Costa | 28 January 1840 | 18 May 1840 |
| 13 | Miguel Chiari Jiménez | 18 May 1840 | 27 May 1840 |
| 14 | Judas Tadeo Landínez | 27 May 1840 | 21 September 1840 |
| 15 | Lino de Pombo O'Donnell | 21 September 1840 | 9 October 1840 |
| 16 | Miguel Chiari Jiménez | 9 October 1840 | 13 May 1841 |
| 17 | Mariano Ospina Rodríguez | 13 May 1841 | 2 October 1843 | Pedro Alcántara Herrán Martínez |
| 18 | Tomás Joaquín de Acosta y Pérez de Guzmán | 2 October 1843 | 1 April 1845 |
| 19 | Juan María Gómez Pastor | 1 April 1845 | 9 October 1849 | Tomás Cipriano de Mosquera y Arboleda |
| 20 | Eusebio Borrero y Costa | 9 October 1849 | 28 May 1846 |
| 21 | Manuel María Mallarino Ibargüen | 28 May 1846 | 7 July 1846 |
| 22 | Juan Antonio Pardo Pardo | 7 July 1846 | 13 October 1846 |
| 23 | Manuel María Mallarino Ibargüen | 13 October 1846 | 20 July 1847 |
| 24 | Manuel Esteban Ancízar Basterra | 20 July 1847 | 7 February 1848 |
| 25 | Manuel María Mallarino Ibargüen | 7 February 1848 | 19 June 1848 |
| 26 | José María Galaviz | 19 June 1848 | 5 December 1848 |
| 27 | Justo Arosemena Quesada | 5 December 1848 | 12 January 1849 |
| 28 | Cerbeleón Pinzón | 12 January 1849 | 1 April 1849 |
| 29 | Manuel Murillo Toro | 1 April 1849 | 16 May 1849 | José Hilario López Valdéz |
| 30 | José Acevedo Tejada | 16 May 1849 | 7 June 1849 |
| 31 | Victoriano de Diego Paredes y Paramato | 7 June 1849 | 1 November 1851 |
| 32 | José María Plata Soto | 1 November 1851 | 1 March 1853 |
| 33 | Lorenzo María Lleras González | 1 March 1853 | 26 November 1853 | José María Obando del Campo |
| 34 | José Caicedo Rojas | 26 November 1853 | 1 January 1854 |
| 35 | Cerbeleón Pinzón | 1 January 1854 | 1 April 1855 |
| 36 | Lino de Pombo O'Donnell | 1 April 1855 | 1 April 1857 |
| 37 | Juan Antonio Pardo Pardo | 1 April 1857 | 1 April 1861 | Mariano Ospina Rodríguez |
| [2] |