This is a list of the singles that topped the Ultratop 50 in the Flanders region of Belgium in 1978.
| Issue date | Song | Artist |
|---|---|---|
| 7 January | "Mull of Kintyre" | Wings |
| 14 January | ||
| 21 January | ||
| 28 January | ||
| 4 February | ||
| 11 February | ||
| 18 February | "If I Had Words" | Scott Fitzgerald & Yvonne Keeley |
| 25 February | ||
| 4 March | ||
| 11 March | "Take a Chance On Me" | ABBA |
| 18 March | "I Can't Stand the Rain" | Eruption |
| 25 March | ||
| 1 April | "Denis" | Blondie |
| 8 April | ||
| 15 April | ||
| 22 April | ||
| 29 April | "Rivers of Babylon" | Boney M. |
| 6 May | ||
| 13 May | ||
| 20 May | ||
| 27 May | ||
| 3 June | ||
| 10 June | ||
| 17 June | ||
| 25 June | ||
| 1 July | ||
| 8 July | ||
| 15 July | "You're the One That I Want" | John Travolta & Olivia Newton-John |
| 22 July | ||
| 29 July | ||
| 5 August | ||
| 12 August | ||
| 19 August | ||
| 26 August | ||
| 2 September | ||
| 9 September | ||
| 16 September | "One for You, One for Me" | La Bionda |
| 23 September | "You're the Greatest Lover" | Luv' |
| 30 September | ||
| 7 October | ||
| 14 October | "Rasputin" | Boney M. |
| 21 October | "Hopelessly Devoted to You" | Olivia Newton-John |
| 28 October | ||
| 4 November | ||
| 11 November | ||
| 18 November | "Summer Nights" | John Travolta & Olivia Newton-John |
| 25 November | "Dreadlock Holiday" | 10cc |
| 2 December | ||
| 9 December | ||
| 16 December | "Trojan Horse" | Luv' |
| 23 December | ||
| 30 December | "Y.M.C.A." | Village People |
| Pos. | Title | Artist | Peak |
|---|---|---|---|
| 1 | "You're the One That I Want" | John Travolta & Olivia Newton-John | 1 |
| 2 | "Follow Me" | Amanda Lear | 3 |
| 3 | "Rivers of Babylon" | Boney M. | 1 |
| 4 | "Only a Fool" | Mighty Sparrow and Byron Lee and the Dragonaires | 2 |
| 5 | "Summertime" | The Shake Spears | 6 |
| 6 | "Stayin' Alive" | Bee Gees | 2 |
| 7 | "Lay Love On You" | Luisa Fernandez | 7 |
| 8 | "Let's All Chant" | The Michael Zager Band | 2 |
| 9 | "Night Fever" | Bee Gees | 3 |
| 10 | "You're the Greatest Lover" | Luv' | 1 |