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| Trade names | Experior |
| Other names | LY-488756 |
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| Formula | C29H29N3O3S |
| Molar mass | 499.63 g·mol−1 |
Lubabegron (trade name Experior) is a veterinary drug used to reduce ammonia emissions from animals and their waste. [1] Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. [2]
Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. [3] [4] It is the first drug approved for reducing ammonia emissions. [5] It is also approved for use in Canada. [6]
Lubabegron is a beta-adrenergic receptor agonist/antagonist. [7] The antagonist activity of lubabegron at β1 and β2 receptors prevents the stimulation of the β-AR found in the heart (β1) and trachea/bronchi (β2) of humans and, in doing so, avoids the potential negative side effects associated with β1 and β2 receptor activation. The β1-AR and β2-AR antagonist behavior of lubabegron could decrease lipolysis in adipose tissue, whereas the β3-AR agonist activity could increase skeletal muscle hypertrophy, possibly due to the differences in the second messenger systems and enzyme expression in skeletal muscle compared with adipose tissues. [8]