Related Research Articles
The Institute of Cancer Research is a public research institute and a member institution of the University of London in London, United Kingdom, specialising in oncology. It was founded in 1909 as a research department of the Royal Marsden Hospital and joined the University of London in 2003. It has been responsible for a number of breakthrough discoveries, including that the basic cause of cancer is damage to DNA.
The Wellcome Trust is a charitable foundation focused on health research based in London, United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of £29.1 billion in 2020, making it the fourth wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the Financial Times as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP £1.1 billion on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome Trust's financing for 2019 development increased by 22% to US$327 million.
Sir Walter Fred Bodmer is a German-born British human geneticist.
The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.
The Cambridge Biomedical Campus is the largest centre of medical research and health science in Europe. The site is located at the southern end of Hills Road in Cambridge, England.
The Cancer Genome Project is part of the cancer, aging, and somatic mutation research based at the Wellcome Trust Sanger Institute in the United Kingdom. It aims to identify sequence variants/mutations critical in the development of human cancers. Like The Cancer Genome Atlas project within the United States, the Cancer Genome Project represents an effort in the War on Cancer to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of the disease. The Cancer Genome Project was launched by Michael Stratton in 2000, and Peter Campbell is now the group leader of the project. The project works to combine knowledge of the human genome sequence with high throughput mutation detection techniques.
Dame Bridget Margaret Ogilvie, is an Australian and British scientist.
The International Cancer Genome Consortium (ICGC) is a voluntary scientific organization that provides a forum for collaboration among the world's leading cancer and genomic researchers. The ICGC was launched in 2008 to coordinate large-scale cancer genome studies in tumours from 50 cancer types and/or subtypes that are of main importance across the globe.
Sir Michael Rudolf Stratton, is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.
COSMIC is an online database of somatically acquired mutations found in human cancer. Somatic mutations are those that occur in non-germline cells that are not inherited by children. COSMIC, an acronym of Catalogue Of Somatic Mutations In Cancer, curates data from papers in the scientific literature and large scale experimental screens from the Cancer Genome Project at the Sanger Institute. The database is freely available to academic researchers and commercially licensed to others.
Allan Bradley FRS is a British geneticist at the Wellcome Trust Sanger Institute.
In molecular biology, kataegis describes a pattern of localized hypermutations identified in some cancer genomes, in which a large number of highly patterned basepair mutations occur in a small region of DNA. The mutational clusters are usually several hundred basepairs long, alternating between a long range of C→T substitutional pattern and a long range of G→A substitutional pattern. This suggests that kataegis is carried out on only one of the two template strands of DNA during replication. Compared to other cancer-related mutations, such as chromothripsis, kataegis is more commonly seen; it is not an accumulative process but likely happens during one cycle of replication.
Simon Tavaré is the founding Director of the Herbert and Florence Irving Institute of Cancer Dynamics at Columbia University. Prior to joining Columbia, he was Director of the Cancer Research UK Cambridge Institute, Professor of Cancer Research at the Department of Oncology and Professor in the Department of Applied Mathematics and Theoretical Physics (DAMTP) at the University of Cambridge.
Elizabeth Jane Robertson is a British developmental biologist based at the Sir William Dunn School of Pathology, University of Oxford. She is Professor of Developmental Biology at Oxford and a Wellcome Trust Principal Research Fellow. She is best known for her pioneering work in developmental genetics, showing that genetic mutations could be introduced into the mouse germ line by using genetically altered embryonic stem cells. This discovery opened up a major field of experimentation for biologists and clinicians.
Timothy John Phillip Hubbard is a Professor of Bioinformatics at King's College London, Head of Genome Analysis at Genomics England and Honorary Faculty at the Wellcome Trust Sanger Institute in Cambridge, UK. From 1 March 2024, Hubbard became the director of Europe's Life Science Data Infrastructure ELIXIR.
Duncan Odom is a research group leader at the German Cancer Research Center (DKFZ) in Heidelberg, and the Cancer Research UK Cambridge Institute at the University of Cambridge. Previously he was as an associate faculty member at the Wellcome Trust Sanger Institute from 2011 to 2018.
Mutational signatures are characteristic combinations of mutation types arising from specific mutagenesis processes such as DNA replication infidelity, exogenous and endogenous genotoxin exposures, defective DNA repair pathways, and DNA enzymatic editing.
Jin Zhang is a Chinese-American biochemist. She is a professor of pharmacology, chemistry and biochemistry, and biomedical engineering at the University of California, San Diego.
Serena Nik-Zainal is a British-Malaysian clinician who is a consultant in clinical genetics and Cancer Research UK advanced clinician scientist at the University of Cambridge. She makes use of genomics for clinical applications. She was awarded the Crick Lecture by the Royal Society in 2021. Serena Nik-Zainal was also recognized as one of the 100 Influential Women in Oncology by OncoDaily.
Julia Lesley Wilson is a British scientist who serves as associate director at the Wellcome Sanger Institute. Her research career investigates transplant rejection, cancer and inflammation. She previously worked at the World Cancer Research Fund and Breakthrough Breast Cancer.
References
- 1 2 3 Ludmil Alexandrov publications indexed by Google Scholar
- 1 2 Alexandrov, Ludmil (2014). Signatures of mutational processes in human cancer (PDF). sanger.ac.uk (PhD thesis). University of Cambridge. OCLC 1064595163. EThOS uk.bl.ethos.708130.
- ↑ "Welcome Dr. Ludmil B. Alexandrov to Bioengineering | Bioengineering". be.ucsd.edu. Retrieved 2018-04-21.
- ↑ "Funded team Stratton". Cancer Research UK. 2017-02-01. Retrieved 2018-04-21.
- ↑ Mexican, Rebecca MossThe New. "Uncovering the origins of cancer". Santa Fe New Mexican. Retrieved 2018-09-25.
- ↑ "The Alexandrov Lab - Team". alexandrov.cloud.ucsd.edu. Retrieved 2024-04-27.
- ↑ Mosaic, Kat Arney. "The DNA detectives who are hunting the causes of cancer". CNN. Retrieved 2018-09-25.
- ↑ "Mutographs of Cancer - CRUK Grand Challenge Project | Wellcome Sanger Institute". www.sanger.ac.uk. Retrieved 2018-04-21.
- ↑ "One Guy With a Supercomputer Who's Chasing the Causes of Cancer". Popular Mechanics. 2018-03-19. Retrieved 2018-09-23.
| International | |
|---|---|
| National | |
| Academics | |