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DNA-directed RNA polymerase II subunit RPB3 is an enzyme that in humans is encoded by the POLR2C gene.
DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the POLR2J gene.
Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.
Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.
General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.
Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.
Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.
Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.
Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.
HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.
RNA polymerase II elongation factor ELL is an enzyme that in humans is encoded by the ELL gene.
Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 gene.
TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.
General transcription factor IIH subunit 2 is a protein that in humans is encoded by the GTF2H2 gene.
Transcription initiation factor TFIID subunit 13 is a protein that in humans is encoded by the TAF13 gene.
General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.
General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.
General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.
In molecular biology, Tat is a protein that is encoded for by the tat gene in HIV-1. Tat is a regulatory protein that drastically enhances the efficiency of viral transcription. Tat stands for "Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the subtype. Tat vastly increases the level of transcription of the HIV dsDNA. Before Tat is present, a small number of RNA transcripts will be made, which allow the Tat protein to be produced. Tat then binds to cellular factors and mediates their phosphorylation, resulting in increased transcription of all HIV genes, providing a positive feedback cycle. This in turn allows HIV to have an explosive response once a threshold amount of Tat is produced, a useful tool for defeating the body's response.
References
- ↑ Estable M, Naghavi M, Kato H, Xiao H, Qin J, Vahlne A, Roeder R (2002). "MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein". J Biomed Sci. 9 (3): 234–245. doi:10.1007/BF02256070. PMID 12065898.
- Niedzielski MF, Hopewell R, Ismail Z, Estable MC (2007). "MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription". Int J Biol Sci. 3 (4): 225–236. doi:10.7150/ijbs.3.225. PMC 1820876 . PMID 17389929.
- MCEF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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