MIR106A

MIR106A
Identifiers
Aliases	MIR106A , MIRN106A, mir-106, mir-106a, microRNA 106a
External IDs	OMIM: 300792 GeneCards: MIR106A
Gene location (Human)
Chr.	X chromosome (human)
End	134,170,278 bp
Orthologs
	406899
	n/a
	ENSG00000284157
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated September 16, 2021

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Related Research Articles

The miR-9 microRNA, is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs are processed from hairpin precursor sequences by the Dicer enzyme. The dominant mature miRNA sequence is processed from the 5' arm of the mir-9 precursor, and from the 3' arm of the mir-79 precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In vertebrates, miR-9 is highly expressed in the brain, and is suggested to regulate neuronal differentiation. A number of specific targets of miR-9 have been proposed, including the transcription factor REST and its partner CoREST.

The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulates gene expression. miR-16, miR-15, mir-195 and miR-497 are related microRNA precursor sequences from the mir-15 gene family. This microRNA family appears to be vertebrate specific and its members have been predicted or experimentally validated in a wide range of vertebrate species.

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families. These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA.

miR-122 is a miRNA that is conserved among vertebrate species. miR-122 is not present in invertebrates, and no close paralogs of miR-122 have been detected. miR-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism in mouse studies. Reduced miR-122 levels are associated with hepatocellular carcinoma. miR-122 also plays an important positive role in the regulation of hepatitis C virus replication.

In molecular biology mir-143 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir–143 is highly conserved in vertebrates. mir-143 is thought be involved in cardiac morphogenesis but has also been implicated in cancer.

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology, mir-221 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.

In molecular biology mir-363 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-367 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-23 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-25 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-25 levels increase in human heart failure, and treatment with an anti-sense RNA molecule (antagomiR) was recently reported to halt disease progression and improves cardiac function in a mouse heart failure model.

MicroRNA 499a is a protein that in humans is encoded by the MIR499A gene.

MicroRNA 148a is a miRNA that in humans is encoded by the MIR148A gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 375 is a protein that in humans is encoded by the MIR375 gene.

MicroRNA 195 is a protein that in humans is encoded by the MIR195 gene.

MicroRNA 223 is a protein that in humans is encoded by the MIR223 gene.

MicroRNA 93 is a functional RNA and a microRNA that in humans is encoded by the MIR93 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000284157 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 106a" . Retrieved 2017-11-13.

Sharma A, Kumar M, Aich J, Hariharan M, Brahmachari SK, Agrawal A, Ghosh B (2009). "Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a". Proc. Natl. Acad. Sci. U.S.A. 106 (14): 5761–6. Bibcode:2009PNAS..106.5761S. doi: 10.1073/pnas.0808743106 . PMC 2659714 . PMID 19307576.
Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Mück C, Laschober GT, Lepperdinger G, Sampson N, Berger P, Herndler-Brandstetter D, Wieser M, Kühnel H, Strasser A, Rinnerthaler M, Breitenbach M, Mildner M, Eckhart L, Tschachler E, Trost A, Bauer JW, Papak C, Trajanoski Z, Scheideler M, Grillari-Voglauer R, Grubeck-Loebenstein B, Jansen-Dürr P, Grillari J (2010). "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging". Aging Cell. 9 (2): 291–6. doi:10.1111/j.1474-9726.2010.00549.x. PMC 2848978 . PMID 20089119.
Zhou H, Guo JM, Lou YR, Zhang XJ, Zhong FD, Jiang Z, Cheng J, Xiao BX (2010). "Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker". J. Mol. Med. 88 (7): 709–17. doi:10.1007/s00109-010-0617-2. PMID 20349219. S2CID 13285873.
Hummel R, Hussey DJ, Michael MZ, Haier J, Bruewer M, Senninger N, Watson DI (2011). "MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma". Ann. Surg. Oncol. 18 (1): 253–60. doi:10.1245/s10434-010-1213-y. PMID 20628822. S2CID 26439245.
Jiang X, Li N (2011). "Induction of MiR-17-3p and MiR-106a [corrected] by TNFα and LPS". Cell Biochem. Funct. 29 (2): 164–70. doi:10.1002/cbf.1728. PMID 21370248. S2CID 26310852.
Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D (2011). "MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition". J. Biol. Chem. 286 (19): 17359–64. doi: 10.1074/jbc.C111.235960 . PMC 3089577 . PMID 21454525.
Yang G, Zhang R, Chen X, Mu Y, Ai J, Shi C, Liu Y, Shi C, Sun L, Rainov NG, Li H, Yang B, Zhao S (2011). "MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status". J. Mol. Med. 89 (10): 1037–50. doi:10.1007/s00109-011-0775-x. PMID 21656380. S2CID 26039378.
Wang Z, Liu M, Zhu H, Zhang W, He S, Hu C, Quan L, Bai J, Xu N (2013). "miR-106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS". Mol. Carcinog. 52 (8): 634–46. doi:10.1002/mc.21899. PMID 22431000. S2CID 22089497.
Feng B, Dong TT, Wang LL, Zhou HM, Zhao HC, Dong F, Zheng MH (2012). "Colorectal cancer migration and invasion initiated by microRNA-106a". PLOS ONE. 7 (8): e43452. Bibcode:2012PLoSO...743452F. doi: 10.1371/journal.pone.0043452 . PMC 3422256 . PMID 22912877.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000284157 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 106a" . Retrieved 2017-11-13.

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MIR106A

Contents

Function

Related Research Articles

References

Further reading