MIR34A Last updated September 25, 2025 Non-coding RNA in the species Homo sapiens
MicroRNA 34a (miR-34a ) is a microRNA that in humans is encoded by the MIR34A gene . [ 3]
Function microRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs . miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.
The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA . The RefSeq represents the predicted microRNA stem-loop.
References 1 2 3 GRCh38: Ensembl release 89: ENSG00000284357 – Ensembl , May 2017 ↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ↑ "Entrez Gene: MicroRNA 34a" . 1 2 3 Zeng H, Hu M, Lu Y, Zhang Z, Xu Y, Wang S, et al. (July 2019). "MicroRNA 34a promotes ionizing radiation-induced DNA damage repair in murine hematopoietic stem cells" . FASEB Journal . 33 (7): 8138– 8147. doi : 10.1096/fj.201802639R . PMID 30922079 . 1 2 3 Yaku K, Okabe K, Nakagawa T (2018). "NAD Metabolism: Implications in Aging and Longevity". Ageing Research Reviews . 47 : 1– 17. doi :10.1016/j.arr.2018.05.006 . PMID 29883761 . S2CID 47002665 . ↑ Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A (2013). "Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders". Cellular Signalling . 25 (10): 1939– 1948. doi :10.1016/j.cellsig.2013.06.007 . PMID 23770291 . ↑ de Gregorio E, Colell A, Morales A, Marí M (2020). "Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease" . International Journal of Molecular Sciences . 21 (11): 3858. doi : 10.3390/ijms21113858 . PMC 7312021 . PMID 32485811 . ↑ Garten A, Schuster S, Penke M, Kiess W (2015). "Physiological and pathophysiological roles of NAMPT and NAD metabolism". Nature Reviews Endocrinology . 11 (9): 535– 546. doi :10.1038/nrendo.2015.117 . PMID 26215259 . S2CID 11670137 . ↑ Cantó C, Auwerx J (2012). "Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?" . Pharmacological Reviews . 64 (1): 166– 187. doi :10.1124/pr.110.003905 . PMC 3616312 . PMID 22106091 . ↑ Imai S, Yoshino J (2013). "The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing" . Diabetes, Obesity and Metabolism . 15 (Suppl 3): 26– 33. doi :10.1111/dom.12171 . PMC 3819727 . PMID 24003918 . 1 2 D'Onofrio N, Servillo L, Balestrieri ML (2018). "SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection" . Antioxidants & Redox Signaling . 28 (8): 711– 732. doi :10.1089/ars.2017.7178 . PMC 5824538 . PMID 28661724 . Further reading Pang RT, Leung CO, Ye TM, Liu W, Chiu PC, Lam KK, Lee KF, Yeung WS (June 2010). "MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells" . Carcinogenesis . 31 (6): 1037– 44. doi : 10.1093/carcin/bgq066 . PMID 20351093 . Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (March 2003). "Vertebrate microRNA genes". Science . 299 (5612): 1540. doi :10.1126/science.1080372 . PMID 12624257 . S2CID 37750545 . Zauli G, Voltan R, di Iasio MG, Bosco R, Melloni E, Sana ME, Secchiero P (May 2011). "miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells" . Clinical Cancer Research . 17 (9): 2712– 24. doi : 10.1158/1078-0432.CCR-10-3244 . PMID 21367750 . Forte E, Salinas RE, Chang C, Zhou T, Linnstaedt SD, Gottwein E, Jacobs C, Jima D, Li QJ, Dave SS, Luftig MA (June 2012). "The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells" . Journal of Virology . 86 (12): 6889– 98. doi :10.1128/JVI.07056-11 . PMC 3393554 . PMID 22496226 . Navarro F, Gutman D, Meire E, Cáceres M, Rigoutsos I, Bentwich Z, Lieberman J (September 2009). "miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53". Blood . 114 (10): 2181– 92. doi :10.1182/blood-2009-02-205062 . PMID 19584398 . Welch C, Chen Y, Stallings RL (July 2007). "MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells". Oncogene . 26 (34): 5017– 22. doi :10.1038/sj.onc.1210293 . PMID 17297439 . S2CID 18158985 . Siemens H, Jackstadt R, Hünten S, Kaller M, Menssen A, Götz U, Hermeking H (December 2011). "miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions" . Cell Cycle . 10 (24): 4256– 71. doi : 10.4161/cc.10.24.18552 . PMID 22134354 . Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Deng G, Dahiya R (2012). "MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells" . PLOS ONE . 7 (1) e29722. Bibcode :2012PLoSO...729722Y . doi : 10.1371/journal.pone.0029722 . PMC 3250472 . PMID 22235332 . Lou WJ, Chen Q, Liu L, Qian C (May 2010). "[ miR-34s--a tumor suppression protein p53 highly related microRNA] " . Yi Chuan = Hereditas . 32 (5): 423– 30. doi : 10.3724/SP.J.1005.2010.00423 . PMID 20466628 . This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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