Senescence or biological aging is the gradual deterioration of functional characteristics in living organisms. The word senescence can refer to either cellular senescence or to senescence of the whole organism. Organismal senescence involves an increase in death rates and/or a decrease in fecundity with increasing age, at least in the latter part of an organism's life cycle.
Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled limit of 125 years. Several researchers in the area, along with "life extensionists", "immortalists" or "longevists", postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition. The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists.
Proceedings of the Royal Society is the main research journal of the Royal Society. The journal began in 1831 and was split into two series in 1905:
The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as indexed by Clarivate's Web of Science.
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease. SENS was first defined by British biogerontologist Aubrey de Grey.
Nature Reviews Microbiology is a monthly peer-reviewed review journal published by Nature Portfolio. It was established in 2003. The journal publishes reviews and perspectives on microbiology, bridging fundamental research and its clinical, industrial, and environmental applications. The editor-in-chief is Ashley York.
Sarcopenia is a type of muscle loss that occurs with aging and/or immobility. It is characterized by the degenerative loss of skeletal muscle mass, quality, and strength. The rate of muscle loss is dependent on exercise level, co-morbidities, nutrition and other factors. The muscle loss is related to changes in muscle synthesis signalling pathways. It is distinct from cachexia, in which muscle is degraded through cytokine-mediated degradation, although both conditions may co-exist. Sarcopenia is considered a component of frailty syndrome. Sarcopenia can lead to reduced quality of life, falls, fracture, and disability.
Chemical Reviews is peer-reviewed scientific journal published twice per month by the American Chemical Society. It publishes review articles on all aspects of chemistry. It was established in 1924 by William Albert Noyes. The editor-in-chief is Sharon Hammes-Schiffer.
Accounts of Chemical Research is a semi-monthly peer-reviewed scientific journal published by the American Chemical Society containing overviews of basic research and applications in chemistry and biochemistry. It was established in 1968 and the editor-in-chief is Cynthia J. Burrows.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences is a fortnightly peer-reviewed scientific journal published by the Royal Society. It publishes original research and review content in a wide range of physical scientific disciplines. Articles can be accessed online a few months prior to the printed journal. All articles become freely accessible two years after their publication date. The current editor-in-chief is John Dainton.
Frailty is a common geriatric syndrome that embodies an elevated risk of catastrophic declines in health and function among older adults. Frailty is a condition associated with ageing, and it has been recognized for centuries. It is a marker of a more widespread syndrome of frailty, with associated weakness, slowing, decreased energy, lower activity, and, when severe, unintended weight loss. As a frequent clinical syndrome in the elderly, various health risks are linked to health deterioration and frailty in older age, such as falls, disability, hospitalization, and mortality. Generally, frailty refers to older adults who lose independence. It also links to the experiences of losing dignity due to social and emotional isolation risk. Frailty has been identified as a risk factor for the development of dementia.
The Web of Science is a paid-access platform that provides access to multiple databases that provide reference and citation data from academic journals, conference proceedings, and other documents in various academic disciplines. Until 1997, it was originally produced by the Institute for Scientific Information. It is currently owned by Clarivate.
College & Research Libraries is a bimonthly peer-reviewed academic journal published by the Association of College and Research Libraries.
Ageing is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species.
Nature Methods is a monthly peer-reviewed scientific journal covering new scientific techniques. It was established in 2004 and is published by Springer Nature under the Nature Portfolio. Like other Nature journals, there is no external editorial board and editorial decisions are made by an in-house team, although peer review by external experts forms a part of the review process. The editor-in-chief is Allison Doerr.
eLife is a not-for-profit, peer-reviewed, open access, scientific journal for the biomedical and life sciences. It was established at the end of 2012 by the Howard Hughes Medical Institute, Max Planck Society, and Wellcome Trust, following a workshop held in 2010 at the Janelia Farm Research Campus. Together, these organizations provided the initial funding to support the business and publishing operations. In 2016, the organizations committed US$26 million to continue publication of the journal.
Ann Patricia Bowling is a British and Irish sociologist and academic, specializing in research on ageing, quality of life, and research methods. Bowling developed the internationally recognized Older People's Quality of Life questionnaire (OPQOL). Bowling was most recently Professor of Health Sciences, University of Southampton (2012–17), where she is now visiting professor.
Clarivate Plc is a British-American publicly traded analytics company that operates a collection of subscription-based services, in the areas of bibliometrics and scientometrics; business / market intelligence, and competitive profiling for pharmacy and biotech, patents, and regulatory compliance; trademark protection, and domain and brand protection. In the academy and the scientific community, Clarivate is known for being the company which calculates the impact factor, using data from its Web of Science product family, that also includes services/applications such as Publons, EndNote, EndNote Click, and ScholarOne. Its other product families are Cortellis, DRG, CPA Global, Derwent, MarkMonitor, CompuMark, and Darts-ip, and also the various ProQuest products and services.
This timeline lists notable events in the history of research into senescence or biological aging, including the research and development of life extension methods, brain aging delay methods and rejuvenation.
