NIH NIDCR Research Career Development Award (1985) NIH MERIT Award (2000) AAAS Fellow (1995) IADR Distinguished Scientist Award (2001) Fulbright Senior Specialist (2007) AIMBE Fellow (2018) Honorary doctorate, University of Oslo (2017)
He has received awards including the NIH MERIT Award and an honorary doctorate from the University of Oslo.[1][3] His research focuses on enamel formation, amelogenin proteins, and biomimetic approaches to dental regeneration.[4]
His training in developmental biology and pathology has informed his research on disease pathways related to developmental processes in healing and regeneration.
Career
Snead joined the faculty at USC's Herman Ostrow School of Dentistry in 1983 as a research associate professor, becoming a full professor in 1997.[1] He served as associate dean for innovation and discovery from 2001 to 2006 and as chair of the Division of Biomedical Sciences from 2012 to 2022.[1] Since 2023, he has chaired the Faculty Development Committee at the school.[1] He is a founding member of the USC Center for Craniofacial Molecular Biology (1989-present) and an affiliate member of the Eli and Edythe Broad Center for Regenerative Medicine (part of USC Stem Cell), 2011-present.[2][1] He holds affiliate faculty positions at the University of Washington (2011-present), Northwestern University (2012-present), and the University of Kansas (2016-present).[1]
He has served as principal investigator on multiple National Institutes of Health (NIH) grants related to enamel biomineralization, nanotechnology for bone and tooth growth, and supramolecular nanofibers for bone regeneration.[5][1] Snead has been continuously funded by competitive grant applications from the NIH since 1981.[1]
Research
Snead's research examines biomineralization in dental enamel, biomimetic strategies for tissue regeneration, and protein-protein interactions in enamel matrix assembly.[1][4] His work includes studies on the role of amelogenin proteins in enamel formation, circadian influences on dental development, peptide-enabled interfaces for restorative dentistry, and supramolecular nanofibers for bone regeneration.[1][4] According to Google Scholar, his publications have received over 14,000 citations, with an h-index of 68.[4][6]
A 1997 book chapter by Simmer and Snead discusses the cloning of the amelogenin cDNA as enabling subsequent genetic and biochemical studies.[7] A 2006 review co-authored by Snead discusses protein-protein interactions in the developing enamel matrix, including amelogenin self-assembly.[8] A 2005 review by Paine and Snead summarizes transgenic animal models for studying enamel defects and amelogenin self-assembly domains.[9]
Reviews cite Snead's work on amelogenin self-assembly and transgenic models in the context of enamel development.[10][11] Snead presented on self-assembly directing enamel formation and regeneration at the 2015 Composites at Lake Louise conference.[12]
His later research applies biomimetic approaches to translational applications. This includes silver diamine fluoride for caries prevention in vulnerable populations.[13] In collaboration with Candan Tamerler, he has developed solid binding peptides for bone regeneration and antimicrobial coatings on implants.[14]
Snead, Malcolm L.; Lau, E. C.; Zeichner-David, M.; Fincham, A. G.; Woo, S. L. C. (1985). "DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein". Biochemical and Biophysical Research Communications. 129 (3): 812–818. doi:10.1016/0006-291x(85)91964-3. PMID4015654.
Lau, E. C.; Mohandas, T. K.; Shapiro, L. J.; Slavkin, H. C.; Snead, M. L. (February 1989). "Human and mouse amelogenin gene loci are on the sex chromosomes". Genomics. 4 (2): 162–168. doi:10.1016/0888-7543(89)90296-6. PMID2563706.
Jabs, E. W.; Müller, U.; Li, X.; Ma, L.; Luo, W.; Haworth, I. S.; Klisak, I.; Sparkes, R.; Mohandas, T. K.; Warman, M. L.; Mulliken, J. B.; Snead, M. L.; Maxson, R. (5 November 1993). "A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis". Cell. 75 (3): 443–450. doi:10.1016/0092-8674(93)90379-5. PMID8221886.
Bartlett, John D.; Ganss, Bernhard; Goldberg, Michel; Moradian-Oldak, Janet; Paine, Michael L.; Snead, Malcolm L.; Wen, Xin; White, Shane N.; Zhou, Yan L. (2006). "Protein-protein interactions of the developing enamel matrix". Current Topics in Developmental Biology. 74: 57–115. doi:10.1016/S0070-2153(06)74003-0. ISBN978-0-12-153174-4. PMID16860665.
Mellon Faculty Mentoring Award, University of Southern California (2010).[1]
Honorary doctorate (doctor honoris causa) from the University of Oslo in 2017, for contributions to dental science, particularly research on tooth development and enamel mineralization.[3][17]
↑Simmer, James P.; Snead, Malcolm L. (1995). Colin Robinson; Jennifer Kirkham; Roger C. Shore (eds.). Molecular Biology of the Amelogenin Gene: Dental Enamel- Formation to Destruction. Boca Raton, FL: CRC Press. pp.59–84. ISBN0849345898.
↑Bartlett, John D.; Ganss, Bernhard; Goldberg, Michel; Moradian-Oldak, Janet; Paine, Michael L.; Snead, Malcolm L.; Wen, Xin; White, Shane N.; Zhou, Yan L. (2006). "Protein-protein interactions of the developing enamel matrix". Current Topics in Developmental Biology. 74: 57–115. doi:10.1016/S0070-2153(06)74003-0. ISBN978-0-12-153174-4. PMID16860665.
↑Paine, Michael L.; Snead, Malcolm L. (2005). "Tooth developmental biology: disruptions to enamel-matrix assembly and its impact on biomineralization". Orthodontics & Craniofacial Research. 8 (4): 239–251. doi:10.1111/j.1601-6343.2005.00346.x. PMID16238603.
↑"Snead awarded honorary doctorate". Center for Craniofacial Molecular Biology, University of Southern California. September 22, 2017. Retrieved 2026-01-25.
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