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The Transporter Classification Database is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins, including ion channels.
Oxaloacetate decarboxylase is a carboxy-lyase involved in the conversion of oxaloacetate into pyruvate.
Acetyl-S-ACP:malonate ACP transferase is an enzyme with systematic name acetyl-(acyl-carrier-protein):malonate S-(acyl-carrier-protein)transferase. This enzyme catalyses the following chemical reaction
Malonyl-S-ACP decarboxylase (EC 4.1.1.87, malonyl-S-acyl-carrier protein decarboxylase, MdcD/MdcE, MdcD,E) is an enzyme with systematic name malonyl-(acyl-carrier-protein) carboxy-lyase. This enzyme catalyses the following chemical reaction
Biotin-independent malonate decarboxylase (EC 4.1.1.88, malonate decarboxylase (without biotin), malonate decarboxylase, MDC) is an enzyme with systematic name malonate carboxy-lyase (biotin-independent). This enzyme catalyses the following chemical reaction
Biotin-dependent malonate decarboxylase (EC 4.1.1.89, malonate decarboxylase (with biotin), malonate decarboxylase) is an enzyme with systematic name malonate carboxy-lyase (biotin-dependent). This enzyme catalyses the following chemical reaction
Carboxybiotin decarboxylase (EC 7.2.4.1, MadB, carboxybiotin protein decarboxylase) is an enzyme with systematic name carboxybiotinyl-(protein) carboxy-lyase. This enzyme catalyses the following chemical reaction
Acetate—[acyl-carrier protein] ligase is an enzyme with systematic name acetate:(acyl-carrier-protein) ligase (AMP-forming). This enzyme catalyses the following chemical reaction
Members of the Alanine or Glycine:Cation Symporter (AGCS) Family (TC# 2.A.25) transport alanine and/or glycine in symport with Na+ and or H+.
The gluconate:H+ symporter (GntP) family (TC# 2.A.8) is a family of transport proteins belonging to the ion transporter (IT) superfamily. Members of the GntP family include known gluconate permeases of E. coli and Bacillus species such as the D-Gluconate:H+ symporter of Bacillus subtillus (GntP; TC# 2.A.8.1.1) and the D-fructuronate/D-gluconate:H+ symporter of E. coli (GntP; TC# 2.A.8.1.3). A representative list of proteins belonging to the GntP family can be found in the Transporter Classification Database.
Phosphate permeases are membrane transport proteins that facilitate the diffusion of phosphate into and out of a cell or organelle. Some of these families include:
The Pho1 phosphate permease family is a family of phosphate transporters belonging to the ion transporter (IT) superfamily. Representative members of the Pho1 family include the putative phosphate transporter PHO1 of Arabidopsis thaliana, and the xenotropic and polytropic murine-leukemia virus receptor Xpr1 of Culex pipiens.
The Malonate Uptake (MatC) family is a constituent of the ion transporter (IT) superfamily. It consists of proteins from Gram-negative and Gram-positive bacteria, simple eukaryotes and archaea. The proteins are of about 450 amino acyl residues in length with 12-14 putative transmembrane segments (TMSs). Closest functionally-characterized homologues are in the DASS family. One member of this family is a putative malonate transporter.
The NhaC family belongs to the Ion Transporter (IT) Superfamily. A representative list of proteins belonging to the NhaC family can be found in the Transporter Classification Database.
The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family (TC# 2.A.63) is a member of the Na+ transporting Mrp superfamily. The CPA3 family consists of bacterial multicomponent K+:H+ and Na+:H+ antiporters. The best characterized systems are the PhaABCDEFG system of Sinorhizobium meliloti (TC# 2.A.63.1.1) that functions in pH adaptation and as a K+ efflux system, and the MnhABCDEFG system of Staphylococcus aureus (TC# 2.A.63.1.3) that functions as a Na+ efflux Na+:H+ antiporter.
The putative actinobacterial holin-X (Hol-X) family was retrieved as a distant member of TC family 1.E.20, suggesting membership of the holin superfamily III. Most Hol-X proteins are less than 200 amino acyl residues (aas) in length and possess two transmembrane segments (TMSs). A representative list of proteins belonging to this family can be found in the Transporter Classification Database.
The Listeria Phage A118 Holin (Hol118) Family is a group of transporters belonging to the Holin Superfamily V. A representative list of proteins belonging to the Hol118 family can be found in the Transporter Classification Database.
The cation:proton antiporter (CPA) superfamily is a superfamily of transport proteins named after one of its constituent members, the monovalent cation:proton antiporter-2 (CPA2).
The Putative Sulfate Exporter (PSE) Family (TC# 2.A.98) is composed of several putative 10 or 11 transmembrane segment (TMS) proteins. This family is part of the CPA superfamily and its members are found in diverse bacteria and archaea. The genes encoding some of these homologues may be induced by growth in the presence of cysteate (suyZ) or taurine (tauZ). Although they differ in structure, these proteins are most closely related to the 12 TMS members of the CPA superfamily and exhibit demonstrable homology to the MadML malonate:H+ symporter (TC #2.A.70), although their sequence similarity is low.
The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family (TC# 3.B.1) is a family of porters that belong to the CPA superfamily. Members of this family have been characterized in both Gram-positive and Gram-negative bacteria. A representative list of proteins belonging to the NaT-DC family can be found in the Transporter Classification Database.
References
- 1 2 "2.A.70 The Malonate:Na+ Symporter (MSS) Family". TCDB. Retrieved 2016-04-06.
- ↑ Chohnan, S.; Kurusu, Y.; Nishihara, H.; Takamura, Y. (1999-05-15). "Cloning and characterization of mdc genes encoding malonate decarboxylase from Pseudomonas putida". FEMS Microbiology Letters. 174 (2): 311–319. doi: 10.1016/s0378-1097(99)00156-1 . ISSN 0378-1097. PMID 10339824.
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