Marc Goldstein

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Marc Goldstein, MD, DSc (hon), FACS is an American urologist and the Matthew P. Hardy Distinguished Professor of Reproductive Medicine, and Urology at Weill Cornell Medical College; Surgeon-in-Chief, Male Reproductive Medicine and Surgery; and Director of the Center of Male Reproductive Medicine and Microsurgery at New York Presbyterian Hospital. [1] [2] He is Adjunct Senior Scientist with the Population Council's Center for Biomedical Research, located on the campus of Rockefeller University.

Contents

He currently serves on the editorial boards of Journal of Andrology and Microsurgery.

Education and Training

Dr. Goldstein graduated summa cum laude from the College of Medicine, State University of New York - Downstate Medical Center in Brooklyn, NY in 1972. He worked as a resident in general surgery at Columbia Presbyterian Hospital (Now New-York Presbyterian) in New York. After three years overseas in the United States Air Force, attaining the rank of Major and flying an F4 Phantom aircraft as a Flight Surgeon, Dr. Goldstein was trained in urology at Downstate Medical Center from 1977 to 1980. He continued his post-graduate training in reproductive physiology as an AUA scholar at the Population Council, Center for Biomedical Research, located on the campus of Rockefeller University, and at the Rockefeller University Hospital.

Medical Specialization and Research

Dr. Goldstein is a specialist in male infertility and scrotal disorders and is internationally renowned for his pioneering work on microsurgical management of male infertility [3] such as vasectomy reversals, [4] varicocelectomy, [5] [6] Hydrocele, Inguinal hernia repair and testis-sparing testicular tumor excision. [7] He was the first American surgeon to be trained in, and perform, the Chinese method of no-scalpel vasectomy. [8] Dr. Goldstein's research has shown that there is a direct link between varicocele and low testosterone [9] and varicocele and loss of fertility in men. [10] His research has also shown that the presence of varicoceles can run in families. [11]

Dr. Goldstein's current research focuses on the relationship between high sperm DNA fragmentation and varicocele, [12] mapping sperm DNA fragmentation in the male genital tract to determine the best surgically retrieved sperm specimen to use for IVF/ICSI [13] and the association between DNA fragmentation and semen parameters. [14]

Dr. Goldstein is also the co-principal investigator in the Shang Ring project in Africa, providing minimally invasive circumcision techniques to remote areas in an attempt to stem the transmission of sexually transmitted infections, such as HIV. [15] The project has received support and grants from both the NIH and the Bill and Melinda Gates Foundation. [16]

Publications

Dr. Goldstein has authored or co-authored 339 journal articles and book chapters, including in Gray's Anatomy, Glenn's Urologic Surgery [17] and Campbell's Urology. [18] He is the author of Surgery of Male Infertility, the first textbook on the subject. He co-edited the updated edition Surgical and Medical Management of Male Infertility with Dr. Peter Schlegel, the Chairman of the Department of Urology at Weill Cornell Medical College, New York Presbyterian Hospital. Dr. Goldstein is also the co-author of The Vasectomy Book, A Baby at Last! and Reproductive Medicine Secrets.

Awards

Dr. Goldstein is the recipient of the Star Award from American Society of Reproductive Medicine in 2011, 2012, 2013, 2014, 2016, 2017, and 2018. He won the John Coleman, MD Teaching Award from the Department of Urology at Weill Cornell Medical College and the Howard and Georgeanna Jones Lifetime Achievement Award from the American Fertility Association. In 2017 he won the Kavoussi Family Outstanding Teacher Award from the American Society of Reproductive Medicine and in 2018 he won the Distinguished Reproductive Urology Award from the Society for the Study of Male Reproduction. In 2008, he received an Honorary Doctor of Science from SUNY Downstate Medical Center.

Dr. Goldstein has been listed in New York Magazine's "America's Top Doctors", beginning in 1990 and continuing presently. He was also listed in Castle-Connolly Medical's "America's Top Doctors" and Marquis Who's Who "Who's Who in America".

Patents

Dr. Goldstein has been at the forefront of male infertility surgical innovation. He holds patents for the Goldstein Microspike Surgical Approximator, [19] the Percutaneous vasectomy method, Method and apparatus for support of tubularization of surgical grafts, microsurgical suture needle, medium for preserving tissue without tissue culturing occurring, the vasectomy procedure and related kit and the multi-needle holding device.

Appearances in the Media

On December 9, 2014, Dr. Goldstein appeared on HuffPost Live to discuss male factor infertility. On October 6, 2014, Dr. Goldstein was quoted in AMNewYork regarded "Man-Spreading". [20] Dr. Goldstein has also appeared on The Katie Couric Show, has been interviewed by New York 1 and The New York Times. [21]

Related Research Articles

<span class="mw-page-title-main">Vasectomy</span> Surgical procedure for male sterilization

Vasectomy is an elective surgical procedure that results in male sterilization, often as a means of permanent contraception. During the procedure, the male vasa deferentia are cut and tied or sealed so as to prevent sperm from entering into the urethra and thereby prevent fertilization of a female through sexual intercourse. Vasectomies are usually performed in a physician's office, medical clinic, or, when performed on a non-human animal, in a veterinary clinic. Hospitalization is not normally required as the procedure is not complicated, the incisions are small, and the necessary equipment routine.

Andrology is a name for the medical specialty that deals with male health, particularly relating to the problems of the male reproductive system and urological problems that are unique to men. It is the counterpart to gynecology, which deals with medical issues which are specific to female health, especially reproductive and urologic health.

<span class="mw-page-title-main">Testicular atrophy</span> Reduction in the size and function of the testicles

Testicular atrophy is a medical condition in which one or both testicles diminish in size and may be accompanied by reduced testicular function. Testicular atrophy is not related to the temporary shrinkage of the surrounding scrotum, which might occur in response to cold temperature.

<span class="mw-page-title-main">Varicocele</span> Medical condition

A varicocele is, in a male person, an abnormal enlargement of the pampiniform venous plexus in the scrotum; in a female person, it is an abnormal painful swelling to the embryologically identical pampiniform venous plexus; it is more commonly called pelvic compression syndrome. In the male varicocele, this plexus of veins drains blood from the testicles back to the heart. The vessels originate in the abdomen and course down through the inguinal canal as part of the spermatic cord on their way to the testis. Varicoceles occur in around 15% to 20% of all men. The incidence of varicocele increase with age.

<span class="mw-page-title-main">Microsurgery</span> Surgery requiring an operating microscope

Microsurgery is a general term for surgery requiring an operating microscope. The most obvious developments have been procedures developed to allow anastomosis of successively smaller blood vessels and nerves which have allowed transfer of tissue from one part of the body to another and re-attachment of severed parts. Microsurgical techniques are utilized by several specialties today, such as general surgery, ophthalmology, orthopedic surgery, gynecological surgery, otolaryngology, neurosurgery, oral and maxillofacial surgery, endodontic microsurgery, plastic surgery, podiatric surgery and pediatric surgery.

Vasovasostomy is a surgery by which vasectomies are partially reversed. Another surgery for vasectomy reversal is vasoepididymostomy.

<span class="mw-page-title-main">Azoospermia</span> Medical condition of a man whose semen contains no sperm

Azoospermia is the medical condition of a man whose semen contains no sperm. It is associated with male infertility, but many forms are amenable to medical treatment. In humans, azoospermia affects about 1% of the male population and may be seen in up to 20% of male infertility situations in Canada.

Terms oligospermia, oligozoospermia, and low sperm count refer to semen with a low concentration of sperm and is a common finding in male infertility. Often semen with a decreased sperm concentration may also show significant abnormalities in sperm morphology and motility. There has been interest in replacing the descriptive terms used in semen analysis with more quantitative information.

Male infertility refers to a sexually mature male's inability to impregnate a fertile female. In humans, it accounts for 40–50% of infertility. It affects approximately 7% of all men. Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity. More recently, advance sperm analyses that examine intracellular sperm components are being developed.

<span class="mw-page-title-main">Testicular sperm extraction</span> Surgical procedure

Testicular sperm extraction (TESE) is a surgical procedure in which a small portion of tissue is removed from the testicle and any viable sperm cells from that tissue are extracted for use in further procedures, most commonly intracytoplasmic sperm injection (ICSI) as part of in vitro fertilisation (IVF). TESE is often recommended to patients who cannot produce sperm by ejaculation due to azoospermia.

<span class="mw-page-title-main">Reproductive medicine</span> Branch of medicine

Reproductive medicine is a branch of medicine concerning the male and female reproductive systems. It encompasses a variety of reproductive conditions, their prevention and assessment, as well as their subsequent treatment and prognosis.

Post-vasectomy pain syndrome (PVPS) is a chronic and sometimes debilitating genital pain condition that may develop immediately or several years after vasectomy. Because this condition is a syndrome, there is no single treatment method, therefore efforts focus on mitigating/relieving the individual patient's specific pain. When pain in the epididymides is the primary symptom, post-vasectomy pain syndrome is often described as congestive epididymitis.

Douglas S. Scherr, M.D. is an American surgeon and specialist in Urologic Oncology. He is currently the Clinical Director of Urologic Oncology at Weill Cornell Medicine. He also holds an appointment at the Rockefeller University as a Visiting Associate Physician. Scherr was the first physician at Cornell to perform a robotic prostatectomy as well as a robotic cystectomy.

The Genetics & IVF Institute (GIVF) is an international provider of infertility and genetics services and products, and also engages in biomedical research in these fields. The Institute was founded in 1984 by Dr. Joseph D. Schulman and associates. GIVF headquarters are in Fairfax, VA, US, and its facilities include locations in Pennsylvania, Minnesota, California, and Texas in the United States, as well as in China, Mexico, and several other countries.

Vasectomy reversal is a term used for surgical procedures that reconnect the male reproductive tract after interruption by a vasectomy. Two procedures are possible at the time of vasectomy reversal: vasovasostomy and vasoepididymostomy. Although vasectomy is considered a permanent form of contraception, advances in microsurgery have improved the success of vasectomy reversal procedures. The procedures remain technically demanding and may not restore the pre-vasectomy condition.

Reproductive surgery is surgery in the field of reproductive medicine. It can be used for contraception, e.g. in vasectomy, wherein the vasa deferentia of a male are severed, but is also used plentifully in assisted reproductive technology. Reproductive surgery is generally divided into three categories: surgery for infertility, in vitro fertilization, and fertility preservation.

<span class="mw-page-title-main">Sherman Silber</span> American physician

Sherman J. Silber is physician specializing in the field of infertility. He invented many of the infertility treatments in use today in the domain of IVF, sperm retrieval, ICSI, vasectomy reversal, tubal ligation reversal, egg and embryo freezing, ovary transplantation, and the reproductive biological clock. He performed the world's first ovary and testicle transplants, created and popularized the microsurgical vasectomy reversal, and popularized ovarian tissue freezing to preserve female fertility. He was the first to research the genetic causes of infertility in men, and developed the TESE-ICSI technique for extracting sperm from men with low or nonexistent sperm counts and direct injection of the sperm into the egg. Additionally, Silber has studied fertility in animals and performed microscopic surgery on chimpanzees, South American bush dogs, Przewalski's horse, gorillas, wolves, and other endangered species.

<span class="mw-page-title-main">Ashok Agarwal</span> Medical Scientist

Ashok Agarwal is the Director of the Andrology Center, and also the Director of Research at the American Center for Reproductive Medicine at Cleveland Clinic, Cleveland, USA. He is Professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, USA. Ashok is a Senior Staff in the Cleveland Clinic's Glickman Urological and Kidney Institute. He has published extensive translational research in human infertility and assisted reproduction.

Antisperm antibodies (ASA) are antibodies produced against sperm antigens.

Ranjith Ramasamy is the former Director of the Reproductive Urology Fellowship program at the University of Miami's Miller School of Medicine.

References

  1. "Marc Goldstein, M.D., F.A.C.S." Cornell University . Retrieved 18 June 2015.
  2. "Dr. Marc Goldstein Named the Matthew P. Hardy Distinguished Professor of Reproductive Medicine and Urology". Weill Cornell Medical College. 31 July 2008. Retrieved 18 June 2015.
  3. Goldstein M; Tanrikut C (2006). "Microsurgical management of male infertility". Nature Clinical Practice Urology. 3 (7): 381–391. doi:10.1038/ncpuro0524. PMID   16835626. S2CID   12595662.
  4. Pavlovich CP; Goldstein M (1997). "Fertility options after vasectomy: a cost-effectiveness analysis". Fertility and Sterility. 67 (1): 133–141. doi: 10.1016/s0015-0282(97)81870-5 . PMID   8986698.
  5. Abdel-Meguid TA; Al-Sayyad A; Tayib A; Farsi HM (2011). "Does varicocele repair improve male infertility? An evidence-based perspective from a randomized, controlled trian". European Association of Urology. 59 (3): 455–461. doi:10.1016/j.eururo.2010.12.008. PMID   21196073.
  6. Goldstein M; Gilbert BR; Dicker AP; Dwosh J; Gnecco C (1992). "Micrsurgical inguinal varicocelectomy with delivery of the testis: an artery and lymphatic sparing technique". The Journal of Urology. 148 (6): 1808–1811. doi:10.1016/s0022-5347(17)37035-0. PMID   1433614.
  7. Hopps CV; Goldstein M (2002). "Ultrasound guided needle localization and microsurgical exploration for incidental non-palpable testicular tumors". Journal of Urology. 168 (3): 1084–1087. doi:10.1016/S0022-5347(05)64580-6.
  8. Li S; Goldstein M; Zhu J; Scherr D (1991). "The no-scalpel vasectomy". The Journal of Urology. 145 (2): 341–344. doi:10.1016/s0022-5347(17)38334-9. PMID   1988727.
  9. Tanrikut C; Goldstein M; Rosoff JS; Lee RK; Nelson CJ; Mulhall JM (2011). "Varicocele as a risk factor for androgen deficiency and effect of repair". BJU International. 108 (9): 1480–1484. doi:10.1111/j.1464-410x.2010.10030.x. PMID   21435152. S2CID   25265168.
  10. Gorelick JI; Goldstein M (1993). "Loss of fertility in men with varicocele". Fertility and Sterility. 59 (3): 613–616. doi: 10.1016/s0015-0282(16)55809-9 . PMID   8458466.
  11. Raman JD; Walmsley K; Goldstein M (2005). "Inheritance of varicoceles". Adult Urology. 65 (6): 1186–1189. doi:10.1016/j.urology.2004.12.057. PMID   15913726.
  12. Dabaja A; Bernie AM; Mehta A; Samplaski M; Li PS; Grober ED; Jarvi K; Goldstein M (2014). "Changes in sperm DNA quality in infertile men following microsurgical varicocelectomy". Annual Meeting of the American Urologic Association.
  13. Winter A; Najari B; Palermo GD; Paduch D; Goldstein M (2015). "DNA fragmentation mapping of the male genital tract". Annual Meeting of the American Urologic Association.
  14. Stahl PJ, Cogan C, Mehta A, Bolyakov A, Paduch DA, Goldstein M (2015). "Concordance among sperm deoxyribonucleic acid integrity assays and semen parameters". Fertility and Sterility. 104 (1): 56–61.e1. doi: 10.1016/j.fertnstert.2015.04.023 . PMID   25989978.
  15. Barone MA; Li PS; Awori QD; Lee RK; Goldstein M (2014). "Clinical trials using the Shang Ring for male circumcision in Africa: a review". Translational Andrology and Urology. 3 (1): 113–124.
  16. "Why Bill Gates Is Jazzed About This Male Circumcision Breakthrough". Inside Philanthropy.
  17. Kim HH; Goldstein M (2010). Graham, SDJ; Keane, TE (eds.). Glenn's Urologic Surgery. Philadelphia: Lippincott, Williams & Wilkins.
  18. Sandlow J; Winfield HN; Goldstein M (2007). Wein, AJ; Kavoussi, LR; Novick, AC; Partin, AW; Peters, CA (eds.). Campbell's Urology (10th ed.). Philadelphia: WB Saunders Company.
  19. Goldstein M (1985). "Microspike approximator for vasovasostomy". Journal of Urology. 134 (1): 74. doi:10.1016/S0022-5347(17)46986-2. PMID   4009827.
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  21. "Well". The New York Times.