Mathuram Santosham | |
---|---|
Born | |
Alma mater | Jawaharlal Institute of Postgraduate Medical Education and Research Johns Hopkins University |
Scientific career | |
Institutions | Johns Hopkins Bloomberg School of Public Health |
Mathuram Santosham is an Indian American physician who is Professor and Chair at the Johns Hopkins Bloomberg School of Public Health. Santosham is best known for his work on oral rehydration therapy and childhood vaccines, with a focus on supporting people from indigenous communities.
Santosham was born to John Wilfred Santosham and Flora Selvanayagam in Vellore. His father was part of the Indian diplomatic service. [1] He didn't enter a proper classroom until he was eight years old. [1] At the age of twelve, Santosham moved to Glasgow, where he attended boarding school. [1] Even at that young age, Santosham knew that he wanted to become a physician, and he was mentored by his teacher, Miss Grant. [1] He studied medicine at the Jawaharlal Institute of Postgraduate Medical Education and Research in Pondicherry. In the final year of his degree he received word that his mother, Flora, had suffered a significant stroke and died whilst visiting family in Baltimore. [1] After graduating in 1970, Santosham moved to the Baltimore, where he enrolled in a training programme at the Church Home and Hospital. Disappointed by the programme, Santosham joined Johns Hopkins University, where he was mentored by Bradley Sack. [1] There he earned a Master of Public Health and became board certified.[ citation needed ]
In the early 1980s, Santosham worked on the health of Native American and Alaska Native communities. [2] His research looked to learn from the heritage of Southwestern tribes and improve tribal health through training and empowerment. He considered health issues that were most crucial to Native communities, including infectious diseases, substance abuse, HIV/AIDS and diabetes. [1] [3] As part of this work, Santosham championed the use of the oral rehydration therapy (now known as pedialyte) to treat diarrheal dehydration. [4] At the time, the medical community were skeptical about the effectiveness of pedialyte. Santosham reformulated the treatment, training a team of outreach workers to support parents in identifying the recommended doses. [1] Santosham established a successful research trial in the Fort Apache Indian Reservation which both demonstrated the impact of pedialyte and showed that sick infants get better faster if they ate food throughout their illness. [5] It was later estimated that this treatment had saved fifty million lives. [5] In 1991 Santosham founded the Johns Hopkins Center for American Indian Health (CAIH), which he directed for fifteen years.
In North America, Native Americans are considerably more likely to die of vaccine-preventable diseases. Santosham led efficacy trials for several childhood vaccinations, including rotavirus, influenza type B and the pneumococcal vaccine. [6] Santosham worked closely with Native American communities to disseminate these vaccinations. [6] His efficacy studies of the Haemophilus influenzae type b (Hib) conjugate vaccine in Navajo children resulted in the near-elimination of the virus in North America. He subsequently launched the $37 million GAVI Alliance Hib Initiative, which looked to deploy the conjugated vaccine in developing countries. [4] [7] When the study started, only 20% of countries eligible for support from GAVI had introduced the vaccination. [3] By 2014, over 95% of GAVI eligible countries had introduce the vaccine into their national immunisation programmes. [3] GAVI estimated that the vaccination would have saved seven million lives by 2020. [3]
An advance market commitment (AMC) is a promise to buy or subsidise a product if it is successfully developed. AMCs are typically offered by governments or private foundations to encourage the development of vaccines or treatments. In exchange, pharmaceutical companies commit to providing doses at a fixed price. This funding mechanism is used when the cost of research and development is too high to be worthwhile for the private sector without a guarantee of a certain quantity of purchases.
Pneumococcal conjugate vaccine is a pneumococcal vaccine made with the conjugate vaccine method and used to protect infants, young children, and adults against disease caused by the bacterium Streptococcus pneumoniae (pneumococcus). It contains purified capsular polysaccharide of pneumococcal serotypes conjugated to a carrier protein to improve antibody response compared to the pneumococcal polysaccharide vaccine. The World Health Organization (WHO) recommends the use of the conjugate vaccine in routine immunizations given to children.
Alfred (Al) Sommer is an American ophthalmologist and epidemiologist at the Johns Hopkins Bloomberg School of Public Health. His research on vitamin A in the 1970s and 1980s revealed that dosing even mildly vitamin A deficient children with an inexpensive, large dose vitamin A capsule twice a year reduces child mortality by as much as 34 percent. The World Bank and the Copenhagen Consensus list vitamin A supplementation as one of the most cost-effective health interventions in the world.
The Expanded Program on Immunization is a global health initiative launched by the World Health Organization in May 1974, with the aim to make vaccines available to all globally
Since 1994, the Albert B. Sabin Gold Medal has been awarded annually by the Sabin Vaccine Institute in recognition of work in the field of vaccinology or a complementary field. It is in commemoration of the pioneering work of Albert B. Sabin.
Jean Marie Okwo-Bele is a Congolese physician, public health expert and former Director of the Department of Immunization, Vaccines and Biologicals of the World Health Organization (WHO).
A homologous booster shot involves the administration of the same vaccine as previously administered, while a heterologous booster shot involves the administration of a different vaccine.
"Heterologous prime-boost immunization is administration of two different vectors or delivery systems expressing the same or overlapping antigenic inserts."
"An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost."
Orin Levine is an epidemiologist known for his work in the fields of international public health, child survival, and pneumonia. He is currently the director of vaccine delivery at the Bill & Melinda Gates Foundation in Seattle, US. In the past he was the executive director of the International Vaccine Access Center (IVAC), the co-chair of the Pneumococcal Awareness Council of Experts (PACE), and is a professor at The Johns Hopkins Bloomberg School of Public Health in the Department of International Health. He is also an adjunct assistant professor of epidemiology at The Rollins School of Public Health at Emory University in Atlanta. Additionally, he is currently president of the American Society of Tropical Medicine and Hygiene (ASTMH) Council on Global Health. He resides in Washington, D.C.
Katherine "Kate" L. O'Brien is a Canadian American pediatric infectious disease physician, epidemiologist, and vaccinologist who specializes in the areas of pneumococcal epidemiology, pneumococcal vaccine trials and impact studies, and surveillance for pneumococcal disease. She is also known as an expert in infectious diseases in American Indian populations. O’Brien is currently the Director of the World Health Organization's Department of Immunization, Vaccines and Biologicals.
David M. Serwadda is a Ugandan physician, medical researcher, academic, public health specialist and medical administrator. Currently he is a Professor of Public Health at Makerere University School of Public Health, one of the schools of Makerere University College of Health Sciences, a semi-autonomous constituent college of Makerere University, the oldest university in Uganda. Serwadda is also a founding member of Accordia Global Health Foundation's Academic Alliance.
Daniel R. Feikin is an American epidemiologist. He specializes in the epidemiology of infectious diseases in developing countries. He currently serves as Director of Epidemiology at the International Vaccine Access Center (IVAC), an organization dedicated to increasing global access to vaccines, at the Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland. He earlier worked at the National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. While working for the CDC he lived for a time in Kisumu, Kenya, from which he and his family had to be evacuated in 2008 due to local violence.
Abdullah H. Baqui is a public health scientist who demonstrated the effectiveness of simple but effective strategies to reduce preventable newborn deaths.
GAVI, officially Gavi, the Vaccine Alliance is a public–private global health partnership with the goal of increasing access to immunization in poor countries. In 2016, Gavi channeled more than half of total donor assistance for health, and most donor assistance for immunization, by monetary measure.
Samir Kumar Saha is an eminent Bangladeshi microbiologist and public health expert. He is the professor, senior consultant and head of the department of Diagnostic Division of Microbiology at the Dhaka Shishu Hospital for children and also the executive director of The Child Health Research Foundation (CHRF) at the Bangladesh Institute of Child Health.
Natalie E. Dean is an American biostatistician specializing in infectious disease epidemiology. Dean is currently an assistant professor of Biostatistics at the University of Florida. Her research involves epidemiological modeling of outbreaks, including Ebola, Zika and COVID-19.
The Gamaleya Research Institute of Epidemiology and Microbiology, previously the N. F. Gamaleya Federal Research Center for Epidemiology & Microbiology, is a Russian medical-research institute within the Ministry of Health of the Russian Federation.
Shabir Ahmed Madhi, is a South African physician who is professor of vaccinology and director of the South African Medical Research Council Respiratory and Meningeal Pathogens Research Unit at the University of the Witwatersrand, and National Research Foundation/Department of Science and Technology Research Chair in Vaccine Preventable Diseases. In January 2021, he was appointed Dean of the Faculty of Health Sciences at the University of the Witwatersrand.
The impact of the COVID-19 pandemic on Native American tribes and tribal communities has been severe and has emphasized underlying inequalities in Native American communities compared to the majority of the American population. The pandemic exacerbated existing healthcare and other economic and social disparities between Native Americans and other racial and ethnic groups in the United States. Along with black Americans, Latinos, and Pacific Islanders, the death rate in Native Americans due to COVID-19 was twice that of white and Asian Americans, with Native Americans having the highest mortality rate of all racial and ethnic groups nationwide. As of January 5, 2021, the mortality impact in Native American populations from COVID-19 was 1 in 595 or 168.4 deaths in 100,000, compared to 1 in 1,030 for white Americans and 1 in 1,670 for Asian Americans. Prior to the pandemic, Native Americans were already at a higher risk for infectious disease and mortality than any other group in the United States.
SCB-2019 is a protein subunit COVID-19 vaccine developed by Clover Biopharmaceuticals using an adjuvant from Dynavax technologies. Positive results of Phase I trials for the vaccine were published in The Lancet and the vaccine completed enrollment of 29,000 participants in Phase II/III trials in July 2021. In September 2021, SCB-2019 announced Phase III results showing 67% efficacy against all cases of COVID-19 and 79% efficacy against all cases of the Delta variant. Additionally, the vaccine was 84% effective against moderate cases and 100% effective against hospitalization.
Joanne Katz is an epidemiologist, biostatistician, and Professor of International Health at the Johns Hopkins Bloomberg School of Public Health. She holds joint appointments in the Departments of Biostatistics, Epidemiology and Ophthalmology within the School of Medicine. Her expertise is in maternal, neonatal, and child health. She has contributed to the design, conduct and analysis of data from large community-based intervention trials on nutritional and other interventions in Indonesia, Philippines, Bangladesh, Nepal, and other countries.
{{cite web}}
: CS1 maint: numeric names: authors list (link)