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Biostatistics is a branch of statistics that applies statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments and the interpretation of the results.
Microarray analysis techniques are used in interpreting the data generated from experiments on DNA, RNA, and protein microarrays, which allow researchers to investigate the expression state of a large number of genes – in many cases, an organism's entire genome – in a single experiment. Such experiments can generate very large amounts of data, allowing researchers to assess the overall state of a cell or organism. Data in such large quantities is difficult – if not impossible – to analyze without the help of computer programs.
Tianwen Tony Cai is a Chinese statistician. He is the Daniel H. Silberberg Professor of Statistics and Vice Dean at the Wharton School of the University of Pennsylvania. He is also professor of Applied Math & Computational Science Graduate Group, and associate scholar at the Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania. In 2008 Cai received the COPSS Presidents' Award.
Fold change is a measure describing how much a quantity changes between an original and a subsequent measurement. It is defined as the ratio between the two quantities; for quantities A and B the fold change of B with respect to A is B/A. In other words, a change from 30 to 60 is defined as a fold-change of 2. This is also referred to as a "one fold increase". Similarly, a change from 30 to 15 is referred to as a "0.5-fold decrease". Fold change is often used when analysing multiple measurements of a biological system taken at different times as the change described by the ratio between the time points is easier to interpret than the difference.
John Quackenbush is an American computational biologist and genome scientist. He is a professor of biostatistics and computational biology and a professor of cancer biology at the Dana–Farber Cancer Institute (DFCI), as well as the director of its Center for Cancer Computational Biology (CCCB). Quackenbush also holds an appointment as a professor of computational biology and bioinformatics in the Department of Biostatistics at the Harvard School of Public Health.
Lee-Jen Wei is a Taiwanese-American professor of biostatistics at Harvard University.
Marvin Zelen was Professor Emeritus of Biostatistics in the Department of Biostatistics at the Harvard T.H. Chan School of Public Health (HSPH), and Lemuel Shattuck Research Professor of Statistical Science. During the 1980s, Zelen chaired HSPH's Department of Biostatistics. Among colleagues in the field of statistics, he was widely known as a leader who shaped the discipline of biostatistics. He "transformed clinical trial research into a statistically sophisticated branch of medical research."
George Chien-Cheng Tseng is a Biostatistician and Professor and Vice Chair for Research in the Department of Biostatistics (primary), Computational & Systems Biology (secondary) and Human Genetics (secondary) at University of Pittsburgh Graduate School of Public Health.
Rafael Irizarry is a professor of biostatistics at the Harvard T.H. Chan School of Public Health and professor of biostatistics and computational biology at the Dana–Farber Cancer Institute. Irizarry is known as one of the founders of the Bioconductor project.
Louise Marie Ryan is an Australian biostatistician, a distinguished professor of statistics in the School of Mathematical Sciences at the University of Technology Sydney, president-elect of the International Biometric Society, and an editor-in-chief of the journal Statistics in Medicine. She is known for her work applying statistics to cancer and risk assessment in environmental health.
Rebecca A. Betensky is a professor of biostatistics and chair of the department of biostatistics at New York University's School of Global Public Health. Previously, she was a professor of biostatistics at the Harvard T.H. Chan School of Public Health, where she directed the biostatistics program for the Harvard Clinical and Translational Science Center. She was also a biostatistician for Massachusetts General Hospital, where she directed the biostatistics core of the Alzheimer’s Disease Research Center.
Kim-Anh Do is an Australian biostatistician of Vietnamese descent. She is the chair of the Department of Biostatistics in the University of Texas MD Anderson Cancer Center, and the holder of the Electa C. Taylor Chair for Cancer Research at the center. She also holds adjunct professorships at Texas A&M University and Rice University.
Jeffrey Tullis Leek is an American biostatistician and data scientist working as a Vice President, Chief Data Officer, and Professor at Fred Hutchinson Cancer Research Center. He is an author of the Simply Statistics blog, and runs several online courses through Coursera, as part of their Data Science Specialization. His most popular course is The Data Scientist's Toolbox, which he instructed along with Roger Peng and Brian Caffo. Leek is best known for his contributions to genomic data analysis and critical view of research and the accuracy of popular statistical methods.
Jean Yee Hwa Yang is an Australian statistician known for her work on variance reduction for microarrays, and for inferring proteins from mass spectrometry data. Yang is a Professor in the School of Mathematics and Statistics at the University of Sydney.
Tianxi Cai is a Chinese biostatistician. She is the John Rock Professor of Population and Translational Data Sciences in the Department of Biostatistics at the Harvard T.H. Chan School of Public Health. Topics in her research include biomarkers, personalized medicine, survival analysis, and health informatics.
Regina Nuzzo is a professor of statistics at Gallaudet University in Washington D.C., a liberal arts school for deaf and hard-of-hearing students. She also writes articles about the importance of statistical and science communication and is an advocate for people with disabilities in the science and technology field.
Rebecca Allana Hubbard is an American biostatistician whose research interests include observational studies and the use of electronic health record data in public health analysis and decision-making, accounting for the errors in this type of data. She is a professor of biostatistics in the Perelman School of Medicine at the University of Pennsylvania.
Hongmei Zhang is a Chinese-American biostatistician at the University of Memphis, where she is Bruns Endowed Professor in the Division of Epidemiology, Biostatistics, and Environmental Health Sciences, director of the division, program coordinator for biostatistics, and affiliated professor in the departments of mathematical sciences and biology. Her statistical interests include feature selection, biclustering, and Bayesian networks; she is also interested in the application of statistical methods to phenotype and genetic data and to epigenetics.
Scarlett Bellamy is an American public health researcher who is a Professor of the Department of Epidemiology and Biostatistics at Drexel University. At Drexel she is Associate Dean of Diversity, Inclusion and Faculty Development.
Jen Sheen is a biologist at Massachusetts General Hospital and Harvard Medical School who is known for her work on plant signaling networks. She is an elected member of the American Association for the Advancement of Science.
References
- 1 2 Featured Alumna: Mei-Ling Ting Lee, University of Pittsburgh Department of Statistics, retrieved 2017-10-16
- 1 2 "Mei-Ling Ting Lee", People, University of Maryland School of Public Health, retrieved 2017-10-16
- 1 2 3 4 Curriculum vitae, September 28, 2012, retrieved 2017-10-16
