Michael P. Snyder

Last updated
Michael Paul Snyder
Born1955
Pottstown, Pennsylvania
NationalityAmerican
Alma materUniversity of Rochester, California Institute of Technology
Occupation(s)Geneticist, Stanford W. Ascherman Professor of Genetics,
Former chair of the genetics department, Stanford University,
Director of the Stanford Center for Genomics and Personalized Medicine
Known forRNA sequencing, ChIP-chip and CHIP-seq(11), genomics, pioneering multi-omic longitudinal health tracking, wearable technology, systems biology, systems medicine
Scientific career
FieldsGenetics, genomics, personalized medicine
Institutions Yale University
Stanford University
Doctoral advisor Dr. Norman Davidson
Other academic advisorsDr. Ronald Davis [1]

Michael Paul Snyder is an American genomicist, professor, and former chair of genetics at Stanford University School of Medicine. He also serves as the director of the Stanford Center for Genomics and Personalized Medicine. [2] [3]

Contents

Snyder's research focuses on "omics", the study of genomes, transcriptomes, proteomes, and other high-throughput omics datasets. His lab has contributed to understanding the genomes and transcriptomes of yeast and humans. The lab also pioneered the use of multi-omic longitudinal profiling to monitor health. [4] [5]

Early life and education

Snyder was born in 1955 and grew up outside of Pottstown, Pennsylvania. [6] [7] His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. He attended Owen J. Roberts High School and later earned a BA in chemistry and biology from the University of Rochester. Snyder completed a PhD in biology from the California Institute of Technology, where he trained in the laboratory of Norman Davidson. [8] [9] He pursued postdoctoral training at Stanford under Ronald W. Davis. [9]

Career and appointments

Snyder began his academic career at Yale University in 1986 as an assistant professor in the department of biology. [8] He was granted tenure at Yale in 1994 and became chair of the new molecular, cellular, and developmental biology (MCDB) department from 1998 to 2004. During his tenure at Yale, he also directed the Center for Genomics and Proteomics. [1] [9] His research at Yale included work on chromosome segregation and cell polarity, leading to the identification of a number of related genes. [10] [11]

In 2009, Snyder joined Stanford University, where he chaired the genetics department until 2024 and directs the Stanford Center for Genomics and Personalized Medicine. [3] [9] He has also served as principal investigator of the Center of Excellence in the Genome Sciences (CEGS) from 2001 to 2011 and was co-director of the CIRM Center for Stem Cell Genomics, [12] as well as director for the Center for Genome of Gene Regulation. [13]

Snyder was president of the US Human Proteome Organization from 2006 to 2008, elected to the American Academy of Arts and Sciences in 2015, and president of the international Human Proteome Organization from 2017 to 2018. [14] He led the National Institutes of Health's Encyclopedia of DNA Elements (ENCODE)'s production center for mapping regulatory regions of the human genome. [15]

Snyder has co-founded biotechnology companies, including Personalis, [16] SensOmics, [17] Qbio, [18] [19] [20] January AI, [21] Filtricine, Mirvie, Protos, Protometrix [22] (now part of Thermo Fisher Scientific), Affomix [23] (now part of Illumina), [24] and Iollo. [25]

Research

Snyder has made contributions to medicine, genomics, and biotechnology. Snyder's laboratory has invented a number of novel systems-wide and genomics technologies, including RNA-Seq for mapping transcriptomes, [26] [27] NextGen Paired end sequencing for mapping genomes, [28] protein microarrays, [29] [30] and ChIP-Chip (later ChIP-Seq) for globally mapping transcription factor binding sites. [31] [32] Snyder's laboratory initially focused on studying the genome of the yeast Saccharomyces cerevisiae, a eukaryote model organism commonly used in genetics and molecular biology, [33] where he launched the large scale analysis of genes and proteins. Later, the lab began to use the same techniques to look at the human genome. [33] His laboratory performed the first multi omics analysis of a human and pioneered the field of precision health. [34]

In 2003, the Encyclopedia of DNA Elements (ENCODE) project was launched by the US National Human Genome Research Institute (NHGRI), with the goal of identifying all functional elements in the human genome. He has been a principal investigator in the ENCODE project since its inception in 2003 and the Snyder lab has contributed a large number of data sets. [9]

Awards

In recognition for "developing and disseminating widely-used technology for the simultaneous analysis of thousands of genes, RNA molecules, and proteins" Snyder received the 2019 Genetics Society of America (GSA) George W. Beadle Award. [35] In 2025, Snyder was awarded the Precision Medicine World Conference Pioneer Award for his contributions to Precision Medicine. [36]

References

  1. 1 2 "Michael P. Snyder".
  2. ↑ "Michael Snyder, Ph.D., STANFORD W. ASCHERMAN PROFESSOR OF GENETICS". Stanford profiles. 20 August 2015. Retrieved 19 April 2022.
  3. 1 2 "Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!". 2 April 2019. Retrieved 16 May 2022.
  4. ↑ Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, et al. (May 2019). "Longitudinal multi-omics of host-microbe dynamics in prediabetes". Nature. 569 (7758): 663–71. Bibcode:2019Natur.569..663Z. doi:10.1038/s41586-019-1236-x. PMC   6666404 . PMID   31142858.
  5. ↑ "How Multi-Omics Profiling Can Redefine Precision Health and Medicine - US". ThermoFisher Scientific.
  6. ↑ "Michael P. Snyder" . Retrieved 16 May 2022.
  7. ↑ Marcus, Amy Dockser (14 May 2012). "What Happens When One Man's Genome Is Revealed". Wall Street Journal. Archived from the original on 2022-04-20. Retrieved 16 May 2022– via www.wsj.com.
  8. 1 2 Sukel, Kayt. "Making It Personal: Geneticist Michael Snyder Puts a Face on Personalized Medicine". Pacific Standard. Retrieved 16 May 2022.
  9. 1 2 3 4 5 Schmidt, Silke (9 April 2019). "Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!". Genetics Society of America. Retrieved 8 February 2021.
  10. ↑ Page BD, Snyder M (August 1992). "CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae". Genes Dev. 6 (8): 1414–29. doi: 10.1101/gad.6.8.1414 . PMID   1644287. S2CID   24949358.
  11. ↑ Roemer T, Madden K, Chang J, Snyder M (April 1996). "Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein". Genes Dev. 10 (7): 777–93. doi: 10.1101/gad.10.7.777 . PMID   8846915.
  12. ↑ "The CIRM Center of Excellence in Stem Cell Genomics (CESCG)". California's Stem Cell Agency. 26 February 2015. Retrieved 16 May 2022.
  13. ↑ "Snyder awarded $7.1 million from genome institute". News Center. Retrieved 16 May 2022.
  14. ↑ "Michael Snyder". American Academy of Arts and Sciences. 13 September 2023.
  15. ↑ "RePORT ⟩ RePORTER".
  16. ↑ Eisenberg, Anne (2 June 2012). "A Geneticist's Research Turns Personal". The New York Times. Retrieved 16 May 2022.
  17. ↑ "SensOmics, See the Unseen". SensOmics, See the Unseen.
  18. ↑ Maxted, Anna (21 January 2020). "What's your ageing type? The four ways we grow old" . Retrieved 16 May 2022– via www.thetimes.co.uk.
  19. ↑ "Our Mission and Values". www.q.bio. Retrieved 16 May 2022.
  20. ↑ magazine, STANFORD (17 November 2021). "Body Count". stanfordmag.org. Retrieved 16 May 2022.
  21. ↑ Ravindran, Sandeep (14 March 2022). "Here Come the Artificial Intelligence Nutritionists". The New York Times. Retrieved 16 May 2022.
  22. ↑ "Invitrogen Buys Protein Chip Maker Protometrix". Genomeweb. 2 April 2004. Retrieved 16 May 2022.
  23. ↑ "Michael Snyder". online.stanford.edu.
  24. ↑ "Snyder Lab". Stanford.edu. Retrieved 2 December 2021.
  25. ↑ Weintraub, Karen. "A geneticist studied one drop of his blood – and saw things he couldn't from a vial of blood". USA TODAY. Retrieved 2025-03-12.
  26. ↑ Wang, Zhong; Gerstein, Mark; Snyder, Michael (January 2009). "RNA-Seq: a revolutionary tool for transcriptomics". Nature Reviews Genetics. 10 (1): 57–63. doi:10.1038/nrg2484. ISSN   1471-0056. PMC   2949280 . PMID   19015660.
  27. ↑ Nagalakshmi, Ugrappa; Wang, Zhong; Waern, Karl; Shou, Chong; Raha, Debasish; Gerstein, Mark; Snyder, Michael (2008-06-06). "The Transcriptional Landscape of the Yeast Genome Defined by RNA Sequencing". Science. 320 (5881): 1344–1349. Bibcode:2008Sci...320.1344N. doi:10.1126/science.1158441. ISSN   0036-8075. PMC   2951732 . PMID   18451266.
  28. ↑ Korbel, Jan O.; Urban, Alexander Eckehart; Affourtit, Jason P.; Godwin, Brian; Grubert, Fabian; Simons, Jan Fredrik; Kim, Philip M.; Palejev, Dean; Carriero, Nicholas J.; Du, Lei; Taillon, Bruce E.; Chen, Zhoutao; Tanzer, Andrea; Saunders, A. C. Eugenia; Chi, Jianxiang (2007-10-19). "Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome". Science. 318 (5849): 420–426. Bibcode:2007Sci...318..420K. doi:10.1126/science.1149504. ISSN   0036-8075. PMC   2674581 . PMID   17901297.
  29. ↑ Zhu, Heng; Bilgin, Metin; Bangham, Rhonda; Hall, David; Casamayor, Antonio; Bertone, Paul; Lan, Ning; Jansen, Ronald; Bidlingmaier, Scott; Houfek, Thomas; Mitchell, Tom; Miller, Perry; Dean, Ralph A.; Gerstein, Mark; Snyder, Michael (2001-09-14). "Global Analysis of Protein Activities Using Proteome Chips". Science. 293 (5537): 2101–2105. Bibcode:2001Sci...293.2101Z. doi:10.1126/science.1062191. ISSN   0036-8075. PMID   11474067.
  30. ↑ Zhu, Heng; Klemic, James F.; Chang, Swan; Bertone, Paul; Casamayor, Antonio; Klemic, Kathryn G.; Smith, David; Gerstein, Mark; Reed, Mark A.; Snyder, Michael (November 2000). "Analysis of yeast protein kinases using protein chips" . Nature Genetics. 26 (3): 283–289. doi:10.1038/81576. ISSN   1546-1718. PMID   11062466.
  31. ↑ Robertson, Gordon; Hirst, Martin; Bainbridge, Matthew; Bilenky, Misha; Zhao, Yongjun; Zeng, Thomas; Euskirchen, Ghia; Bernier, Bridget; Varhol, Richard; Delaney, Allen; Thiessen, Nina; Griffith, Obi L.; He, Ann; Marra, Marco; Snyder, Michael (August 2007). "Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing" . Nature Methods. 4 (8): 651–657. doi:10.1038/nmeth1068. ISSN   1548-7105. PMID   17558387.
  32. ↑ Iyer, Vishwanath R.; Horak, Christine E.; Scafe, Charles S.; Botstein, David; Snyder, Michael; Brown, Patrick O. (January 2001). "Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF" . Nature. 409 (6819): 533–538. Bibcode:2001Natur.409..533I. doi:10.1038/35054095. ISSN   1476-4687. PMID   11206552.
  33. 1 2 Bechard, Deni Ellis (December 2021). "Body Count: How Michael Snyder's self-monitoring project could transform human health". Stanford Magazine. Retrieved 2 December 2021.
  34. ↑ Mason, Christine Marie. "Episode # 152: You As a Data Stream". The Rose Woman Podcast. Retrieved 10 August 2025.
  35. ↑ "Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!". Genes to Genomes. Retrieved 2025-03-12.
  36. ↑ "Speaker Template". PMWC Precision Medicine World Conference. Retrieved 2025-03-12.
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