Michael P. Snyder

Last updated
Michael Paul Snyder
Born1955
Pottstown, Pennsylvania
NationalityAmerican
Alma materUniversity of Rochester California Institute of Technology
Occupation(s)Geneticist, Stanford W. Ascherman Professor
chair of genetics department, Stanford University
director of the Center for Genomics and Personalized Medicine
Known forRNA sequencing, ChIP-chip and CHIP-seq(11), genomics, pioneering multi-omic longitudinal health tracking, wearable technology, systems biology, systems medicine
Scientific career
FieldsGenetics, genomics, personalized medicine
Institutions Yale University
Stanford University
Doctoral advisor Dr. Norman Davidson
Other academic advisorsDr. Ronald Davis [1]

Michael Paul Snyder is an American genomicist, a Stanford School of Medicine professor, and chair of genetics and director of genomics and personalized medicine at Stanford University. [2] [3]

Contents

Snyder's research has focused on "omics", the study of genomes, transcriptomes, proteomes, and other "-omes". His lab's work has specifically contributed to understanding the genomes and transcriptomes of first yeast and now humans. The Snyder lab pioneered the use of multi-omic longitudinal profiling to track health. [4] [5]

Early life and education

Snyder was born in 1955 and grew up outside of Pottstown, Pennsylvania. [6] [7] His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. Snyder attended Owen J. Roberts High school in Pottstown. He received a BA in chemistry and biology from the University of Rochester, NY and went on to receive a PhD in biology from the California Institute of Technology, where he trained in the laboratory of Norman Davidson. [8] [9] Snyder completed his postdoctoral training at Stanford University School of Medicine in the laboratory of Ronald W. Davis. [9]

Career and appointments

Snyder started at Yale University in 1986 as an assistant professor in the department of biology. [8] He was granted tenure at Yale in 1994. In 1998, the department of biology split; Snyder served as chair of the new molecular, cellular and developmental biology (MCDB) department until 2004 as well as the director for the Center for Genomics and Proteomics. [1] [9] His laboratory worked on chromosome segregation and cell polarity, which led to the discovery of a number of genes involved in these processes. [10] [11]

In 2009, Snyder moved to Stanford University where he chaired the genetics department and directed the Center for Genomics and Personalized Medicine. [3] [9] Snyder has served as principal investigator of the Center of Excellence in the Genome Sciences (CEGS) from 2001 to 2011 and is currently co-director of the CIRM Center for Stem Cell Genomics, [12] as well as director for the Center for Genome of Gene Regulation. [13]

Snyder was president of the US Human Proteome Organization from 2006 to 2008, elected to the American Academy of Arts and Sciences in 2015, and president of the international Human Proteome Organization from 2017 to 2018. [14] He currently leads the National Institutes of Health's Encyclopedia of DNA Elements (ENCODE)'s production center for mapping regulatory regions of the human genome. [15]

Snyder has co-founded biotechnology companies, including Personalis, [16] SensOmics, [17] Qbio, [18] [19] [20] January AI, [21] Filtricine, Mirvie, Protos, Protometrix [22] (now part of Thermo Fisher Scientific), and Affomix [23] (now part of Illumina). [24]

Research

Snyder has made contributions to medicine, genomics, and biotechnology. Snyder's laboratory has invented a number of novel systems-wide and genomics technologies. Snyder's laboratory initially focused on studying the genome of the yeast Saccharomyces cerevisiae, a eukaryote model organism commonly used in genetics and molecular biology. [25] Later, the lab began to use the same techniques to look at the human genome. [25]

In 2003, the Encyclopedia of DNA Elements (ENCODE) project was launched by the US National Human Genome Research Institute (NHGRI), with the goal of identifying all functional elements in the human genome. He has been a principal investigator in the ENCODE project since its inception in 2003 and the Snyder lab has contributed a large number of data sets. [9]

Related Research Articles

<span class="mw-page-title-main">Proteome</span> Set of proteins that can be expressed by a genome, cell, tissue, or organism

The proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. Proteomics is the study of the proteome.

<span class="mw-page-title-main">Phenotype</span> Composite of the organisms observable characteristics or traits

In genetics, the phenotype is the set of observable characteristics or traits of an organism. The term covers the organism's morphology, its developmental processes, its biochemical and physiological properties, its behavior, and the products of behavior. An organism's phenotype results from two basic factors: the expression of an organism's genetic code and the influence of environmental factors. Both factors may interact, further affecting the phenotype. When two or more clearly different phenotypes exist in the same population of a species, the species is called polymorphic. A well-documented example of polymorphism is Labrador Retriever coloring; while the coat color depends on many genes, it is clearly seen in the environment as yellow, black, and brown. Richard Dawkins in 1978 and then again in his 1982 book The Extended Phenotype suggested that one can regard bird nests and other built structures such as caddisfly larva cases and beaver dams as "extended phenotypes".

<span class="mw-page-title-main">Genomics</span> Discipline in genetics

Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain.

<span class="mw-page-title-main">Proteomics</span> Large-scale study of proteins

Proteomics is the large-scale study of proteins. Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body.

<span class="mw-page-title-main">Leroy Hood</span> American biologist (born 1938)

Leroy "Lee" Edward Hood is an American biologist who has served on the faculties at the California Institute of Technology (Caltech) and the University of Washington. Hood has developed ground-breaking scientific instruments which made possible major advances in the biological sciences and the medical sciences. These include the first gas phase protein sequencer (1982), for determining the sequence of amino acids in a given protein; a DNA synthesizer (1983), to synthesize short sections of DNA; a peptide synthesizer (1984), to combine amino acids into longer peptides and short proteins; the first automated DNA sequencer (1986), to identify the order of nucleotides in DNA; ink-jet oligonucleotide technology for synthesizing DNA and nanostring technology for analyzing single molecules of DNA and RNA.

<span class="mw-page-title-main">Molecular genetics</span> Scientific study of genes at the molecular level

Molecular genetics is a branch of biology that addresses how differences in the structures or expression of DNA molecules manifests as variation among organisms. Molecular genetics often applies an "investigative approach" to determine the structure and/or function of genes in an organism's genome using genetic screens. 

<span class="mw-page-title-main">Omics</span> Suffix in biology

The branches of science known informally as omics are various disciplines in biology whose names end in the suffix -omics, such as genomics, proteomics, metabolomics, metagenomics, phenomics and transcriptomics. Omics aims at the collective characterization and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms.

<span class="mw-page-title-main">Institute for Systems Biology</span> American non-profit research institute

Institute for Systems Biology (ISB) is a non-profit research institution located in Seattle, Washington, United States. ISB concentrates on systems biology, the study of relationships and interactions between various parts of biological systems, and advocates an interdisciplinary approach to biological research.

<span class="mw-page-title-main">George Church (geneticist)</span> American geneticist

George McDonald Church is an American geneticist, molecular engineer, chemist, serial entrepreneur, and pioneer in personal genomics and synthetic biology. He is the Robert Winthrop Professor of Genetics at Harvard Medical School, Professor of Health Sciences and Technology at Harvard University and Massachusetts Institute of Technology, and a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

The Max Planck Institute for Molecular Genetics is a research institute for molecular genetics based in Berlin, Germany. It is part of the Max Planck Institute network of the Max Planck Society for the Advancement of Science.

<span class="mw-page-title-main">David Haussler</span> American bioinformatician

David Haussler is an American bioinformatician known for his work leading the team that assembled the first human genome sequence in the race to complete the Human Genome Project and subsequently for comparative genome analysis that deepens understanding the molecular function and evolution of the genome.

<span class="mw-page-title-main">Victor Velculescu</span>

Victor E. Velculescu is a Professor of Oncology and Co-Director of Cancer Biology at Johns Hopkins University School of Medicine. He is internationally known for his discoveries in genomics and cancer research.

Clinomics is the study of -omics data along with its associated clinical data. The term -omics generally refers to a study of biology. As an example, genomics is the study of the entire genome of an organism and was the first -omics term.

<span class="mw-page-title-main">Edison Liu</span>

Edison T. Liu is an American chemist who is the former president and CEO of The Jackson Laboratory, and the former director of its NCI-designated Cancer Center (2012-2021). Before joining The Jackson Laboratory, he was the founding executive director of the Genome Institute of Singapore (GIS), chairman of the board of the Health Sciences Authority, and president of the Human Genome Organization (HUGO) (2007-2013). As the executive director of the GIS, he brought the institution to international prominence as one of the most productive genomics institutions in the world.

<span class="mw-page-title-main">Barbara Wold</span> Professor of Molecular Biology

Barbara J. Wold is the Bren Professor of Molecular Biology, the principal investigator of the Wold Lab at the California Institute of Technology (Caltech) and the principal investigator of the Functional Genomics Resource Center at the Beckman Institute at Caltech. Wold was director of the Beckman Institute at Caltech from 2001 to 2011.

<span class="mw-page-title-main">Manolis Kellis</span> Greek-born computational biologist

Manolis Kellis is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.

<span class="mw-page-title-main">Anton Gartner</span>

Anton Gartner is a geneticist and biologist utilizing the nematode worm Caenorhabditis elegans as a model system He is a distinguished professor at the Ulsan National Institute of Science and Technology (UNIST) in Korea and is one of the two associate directors of the IBS Center for Genomic Integrity located on the UNIST campus.

Paul A. Khavari is the Carl J. Herzog Professor at the Stanford University School of Medicine and the Founding Co-Director of the Stanford Program in Epithelial Biology. He is an elected member of the National Academy of Medicine.

Teresa Shu-Fong Wang is an American biochemist. She is a professor emeritus at Stanford University, and the K. Bensch Endowed Chair Professor in Experimental Pathology of Department of Pathology at the Stanford University School of Medicine. Her scientific pursuit focuses on the biochemical mechanisms of chromosome replication proteins, and molecular mechanisms of their involvement in maintaining genome integrity during chromosome replication.

References

  1. 1 2 "Michael P. Snyder".
  2. ↑ "Michael Snyder, Ph.D., STANFORD W. ASCHERMAN PROFESSOR OF GENETICS". Stanford profiles. 20 August 2015. Retrieved 19 April 2022.
  3. 1 2 "Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!". 2 April 2019. Retrieved 16 May 2022.
  4. ↑ Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, et al. (May 2019). "Longitudinal multi-omics of host-microbe dynamics in prediabetes". Nature. 569 (7758): 663–71. Bibcode:2019Natur.569..663Z. doi:10.1038/s41586-019-1236-x. PMC   6666404 . PMID   31142858.
  5. ↑ "How Multi-Omics Profiling Can Redefine Precision Health and Medicine - US". ThermoFisher Scientific.
  6. ↑ "Michael P. Snyder" . Retrieved 16 May 2022.
  7. ↑ Marcus, Amy Dockser (14 May 2012). "What Happens When One Man's Genome Is Revealed". Wall Street Journal. Archived from the original on 2022-04-20. Retrieved 16 May 2022– via www.wsj.com.
  8. 1 2 Sukel, Kayt. "Making It Personal: Geneticist Michael Snyder Puts a Face on Personalized Medicine". Pacific Standard. Retrieved 16 May 2022.
  9. 1 2 3 4 5 Schmidt, Silke (9 April 2019). "Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!". Genetics Society of America. Retrieved 8 February 2021.
  10. ↑ Page BD, Snyder M (August 1992). "CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae". Genes Dev. 6 (8): 1414–29. doi: 10.1101/gad.6.8.1414 . PMID   1644287. S2CID   24949358.
  11. ↑ Roemer T, Madden K, Chang J, Snyder M (April 1996). "Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein". Genes Dev. 10 (7): 777–93. doi: 10.1101/gad.10.7.777 . PMID   8846915.
  12. ↑ "The CIRM Center of Excellence in Stem Cell Genomics (CESCG)". California's Stem Cell Agency. 26 February 2015. Retrieved 16 May 2022.
  13. ↑ "Snyder awarded $7.1 million from genome institute". News Center. Retrieved 16 May 2022.
  14. ↑ "Michael Snyder". American Academy of Arts and Sciences. 13 September 2023.
  15. ↑ "RePORT ⟩ RePORTER".
  16. ↑ Eisenberg, Anne (2 June 2012). "A Geneticist's Research Turns Personal". The New York Times. Retrieved 16 May 2022.
  17. ↑ "SensOmics, See the Unseen". SensOmics, See the Unseen.
  18. ↑ Maxted, Anna. "What's your ageing type? The four ways we grow old" . Retrieved 16 May 2022– via www.thetimes.co.uk.
  19. ↑ "Our Mission and Values". www.q.bio. Retrieved 16 May 2022.{{cite web}}: Check |url= value (help)
  20. ↑ magazine, STANFORD (17 November 2021). "Body Count". stanfordmag.org. Retrieved 16 May 2022.
  21. ↑ Ravindran, Sandeep (14 March 2022). "Here Come the Artificial Intelligence Nutritionists". The New York Times. Retrieved 16 May 2022.
  22. ↑ "Invitrogen Buys Protein Chip Maker Protometrix". Genomeweb. 2 April 2004. Retrieved 16 May 2022.
  23. ↑ "Michael Snyder". online.stanford.edu.
  24. ↑ "Snyder Lab". Stanford.edu. Retrieved 2 December 2021.
  25. 1 2 Bechard, Deni Ellis (December 2021). "Body Count: How Michael Snyder's self-monitoring project could transform human health". Stanford Magazine. Retrieved 2 December 2021.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.