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Michael P Snyder | |
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Born | 1955 |
Nationality | American |
Alma mater | University of Rochester California Institute of Technology |
Occupation(s) | Geneticist, Stanford B. Ascherman Professor chair of genetics department, Stanford University director of the Center for Genomics and Personalized Medicine |
Known for | RNA sequencing, ChIP-chip and CHIP-seq(11), genomics, pioneering multi-omic longitudinal health tracking, wearable technology, systems biology, systems medicine |
Scientific career | |
Fields | Genetics, genomics, personalized medicine |
Institutions | Yale University Stanford University |
Doctoral advisor | Dr. Norman Davidson |
Other academic advisors | Dr. Ronald Davis [1] |
Michael P. Snyder is an American genomicist and the Stanford B. Ascherman Professor, [2] [3] and since 2009, chair of genetics and director of genomics and personalized medicine at Stanford University. [2] He is the former director of the Yale Center for Genomics and Proteomics. [1] He was elected to the American Academy of Arts and Sciences in 2015. [4] During his tenure as chair of the department at Stanford, U.S. News & World Report has ranked Stanford University first or tied for first in genetics, genomics and bioinformatics. [5]
Snyder has co-founded companies in genetics, genomics, and personalized medicine, including Personalis, [6] a company that develops software to interpret genomes after sequencing; January AI, [7] a health startup; Protometrix; [8] Affomix; [9] and Q Bio. [10]
Snyder has been a principal investigator of the ENCODE project since its inception in 2003, [11] and co-director of the CIRM Center for Stem Cell Genomics [12] and director of the Center for Genome of Gene Regulation. [13]
Snyder pioneered the use of multi-omic longitudinal profiling to track health. [14] [15]
Snyder was born in 1955 and grew up outside of Pottstown, Pennsylvania. [16] [17] His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. Snyder attended Owen J Roberts High school in Pottstown. He received a BA in chemistry and biology from the University of Rochester, NY on a scholarship. [18] He went on to receive a PhD in biology from the California Institute of Technology, where he trained in the laboratory of Norman Davidson. [19] Snyder completed his postdoctoral training at Stanford University School of Medicine in the laboratory of Ronald W. Davis. [19] There he was involved in several projects including establishment of successful cloning of genes using antibodies. [4]
Snyder worked at Yale University in 1986 as an assistant professor in the department of biology, [18] and was granted tenure in 1994. In 1998, the department of biology split and Snyder served as chair of the new molecular, cellular and developmental biology (MCDB) department until 2004. [19] His laboratory worked on chromosome segregation and cell polarity, and discovered a number of genes involved in these processes. [20] [21]
His laboratory proposed the first models by which eukaryotes select sites of cell growth. [22] [21]
In 2009, Snyder chaired the genetics department at Stanford University and directed the Center for Genomics and Personalized Medicine. [3] [19] Snyder was principal investigator of the Center of Excellence in the Genome Sciences (CEGS) from 2001 to 2011, was principal investigator for NIH Training Grants in Genomics and Proteomics (first at Yale, now at Stanford) from 2004, and is co-director of the CIRM Center for Stem Cell Genomics [23] and director for the Center for Genome of Gene Regulation. [24] Snyder was president of the US Human Proteome Organization from 2006 to 2008, and the international Human Proteome Organization from 2017 to 2018. He currently leads the National Institutes of Health's Encyclopedia of DNA Elements (ENCODE)'s production center for mapping regulatory regions of the human genome. [25]
Snyder has co-founded biotechnology companies, including Personalis, [6] SensOmics, [26] Qbio, [10] [27] [28] January AI, [7] Filtricine, Mirvie, Protos, Protometrix [8] (now part of Thermo Fisher Scientific), and Affomix [9] (now part of Illumina). [29]
Snyder has made contributions to medicine, genomics and biotechnology. Snyder's laboratory has invented a number of novel systems-wide and genomics technologies. Snyder's laboratory at Yale initially focused on studying the genome of the yeast Saccharomyces cerevisiae, a eukaryote model organism commonly used in genetics and molecular biology. [30] Later, the lab began to use the same techniques to look at the human genome. [30]
In 2003, the Encyclopedia of DNA Elements (ENCODE) project was launched by the US National Human Genome Research Institute (NHGRI), with the goal of identifying all functional elements in the human genome. He has been a principal investigator in the ENCODE project since its inception in 2003 and his lab has contributed a large number of data sets. [19]
Mark Bender Gerstein is an American scientist working in bioinformatics and Data Science. As of 2009, he is co-director of the Yale Computational Biology and Bioinformatics program.
25-Hydroxyvitamin D 1-alpha-hydroxylase also known as calcidiol 1-monooxygenase or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.
Polycystin 1 (PC1) is a protein that in humans is encoded by the PKD1 gene. Mutations of PKD1 are associated with most cases of autosomal dominant polycystic kidney disease, a severe hereditary disorder of the kidneys characterised by the development of renal cysts and severe kidney dysfunction.
Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene.
Cone-rod homeobox protein is a protein that in humans is encoded by the CRX gene.
Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B is a protein that in humans is encoded by the MAFB gene. This gene maps to chromosome 20q11.2-q13.1, consists of a single exon and spans around 3 kb.
Potassium voltage-gated channel subfamily H member 1 is a protein that in humans is encoded by the KCNH1 gene.
AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene.
39S ribosomal protein L12, mitochondrial is a protein that in humans is encoded by the MRPL12 gene.
Small EDRK-rich factor 2 is a protein that in humans is encoded by the SERF2 gene.
39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.
28S ribosomal protein S18b, mitochondrial is a protein that in humans is encoded by the MRPS18B gene.
39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.
Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.
Proton myo-inositol cotransporter, also known as solute carrier family 2 member 13 is a protein that in humans is encoded by the SLC2A13 gene.
Piezo-type mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2 gene. It has a homotrimeric structure, with three blades curving into a nano-dome, with a diameter of 28 nanometers.
Multiomics, multi-omics, integrative omics, "panomics" or "pan-omics" is a biological analysis approach in which the data sets are multiple "omes", such as the genome, proteome, transcriptome, epigenome, metabolome, and microbiome ; in other words, the use of multiple omics technologies to study life in a concerted way. By combining these "omes", scientists can analyze complex biological big data to find novel associations between biological entities, pinpoint relevant biomarkers and build elaborate markers of disease and physiology. In doing so, multiomics integrates diverse omics data to find a coherently matching geno-pheno-envirotype relationship or association. The OmicTools service lists more than 99 softwares related to multiomic data analysis, as well as more than 99 databases on the topic.
Ross C. Hardison is an American biochemist and molecular biologist, currently the T. Ming Chu Professor of Biochemistry and Molecular Biology at the Eberly College of Science, of the Pennsylvania State University.
Solute carrier family 39 member 12 is a protein that in humans is encoded by the SLC39A12 gene.
Manolis Kellis is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.
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