As a board-certified urologist and fellowship-trained surgeon, he specializes in the diagnosis and treatment of kidney, ureter, adrenal, bladder and prostate disease.[citation needed]
Palese performed the first robotic radical nephrectomy, robotic partial nephrectomy, robotic donor nephrectomy, robotic nephroureterectomy, robotic adrenalectomy, and robotic ureteral reimplant & reconstruction at the Mount Sinai Medical Center in New York City. He holds several patents for the design of novel surgical devices. He pioneered Single Port (SP) Robotic Donor Nephrectomy surgery and performed the world’s first procedrure in 2019. [citation needed]
He has been included in the Castle Connolly's List of America's “Top Doctors” in 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 & 2026 and The New York Times publication of “Superdoctors” in 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 & 2026.[citation needed]
In 2004, Palese joined the Mount Sinai Medical Center where he established the robotic surgery program for the Department of Urology. He served as the Chief of Urology at the North General Hospital in New York City from 2004 to 2008.[1]
Professional activities, memberships and distinctions: Palese is the author of book chapters and more than one hundred articles and abstracts. He is on the Medical Advisory Board of the National Kidney Foundation of Greater New York and is a reviewer and consultant for the periodicals of the Journal of Urology, Urology, Urologic Oncology and Journal of Endourology . He is an Editor for the Urologic Oncology (Journal): Seminars and Original Investigations in the section of New Technologies. He is on the steering committee for the Initiative on Kidney Cancer sponsored by the National Kidney Foundation. He also serves on the Medical Advisory Board to the New York Giants. He is a member of multiple organizations including the American Medical Association (AMA), the American Urological Association (AUA), the New York Section of the American Urological Association and the Society of Laparoscopic Surgeons (SLS).[citation needed]
Palese lectures and presents his clinical research at national and international medical conferences. As a Visiting Professor he has performed live surgery and given clinical talks in the United States, Austria, Argentina, Canada, Chile, France, Germany, India, Italy, Japan, Poland, Portugal, Spain, and the United Arab Emirates. He teaches and mentors college students, medical students, residents and fellows. He is a course director and faculty member for several educational courses to teach urologists and other physicians. In particular he is a faculty member for the annual Basic Laparoscopy Course sponsored by the American Urological Association in Houston, Texas. He has been a guest faculty member for Laparoscopy Courses in Buenos Aires, Argentina. He has also been the Course Director for several robotic surgery and advanced prostate courses & workshops held at Mount Sinai. He has been featured in the news media on multiple occasions including the New York Times, Wall Street Journal, New York Daily News, CBS, CNN and WPIX TV.[citation needed]
Palese is included in the Castle Connolly Medical LTD America's Top Doctors and Top Doctor for Cancer edition, The New York Times published Superdoctors and the New York magazine's annual Top Doctors issue.[citation needed]
Super Doctors of New York (The New York Times) -2026, 2025, 2024, 2023, 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009
New York Magazine: Top Doctors -2025, 2024, 2023, 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011*New York Metro Area Top Doctor: Castle Connolly Medical LTD - 2025 (28th Edition), 2024 (27th Edition), 2023 (26th Edition), 2022 (25th Edition), 2021 (22nd Edition), 2020 (23rd Edition), 2019 (22nd Edition), 2018 (21st Edition), 2017 (20th Edition), 2016 (19th Edition), 2015 (18th Edition), 2014 (17th Edition), 2013 (16th Edition), 2012 (15th Edition), 2011 (14th Edition), 2010 (13th Edition)
Resident Achievement Award: Society of Laparoendoscopic Surgeons (SLS) 2003
Pfizer Scholar Award and Grant 2003
Gerald P. Murphy Scholar 2003
Emil Tanagho Prize for Best Innovative Research; International Society for Sexual and Impotence Research (ISSIR) 2002
Sponseller Award for Excellence in Research 2002
National Kidney Foundation of Maryland Grant; (NKF) 2001-2002
Clinical trials
Current clinical trials include:
High Intensity Focused Ultrasound (HIFU) Ablation for Treatment of Prostate Tissue in Bladder Outlet Obstruction (HIFU for BOO) ClinicalTrials.gov ID NCT07194187. Sponsor Icahn School of Medicine at Mount Sinai. Information provided by Michael Palese, Icahn School of Medicine at Mount Sinai (Responsible Party). Last Update Posted 2025-09-26.
GCO#1: 19-0017(0001) ISMMS. A head-to-head comparison of Rezum and UroLift for the treatment of benign prostatic hyperplasia. Dates: 1/11/2019 until 1/10/2023 inclusive.
GCO#13-0476/BRANY File #12-11-438-05/Argos Therapeutics Protocol AGS-003-007. An International Phase 3 Randomized Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma (ADAPT) Role: Principal Investigator.
GCO# 11-1290-00001-01-PD. MSSM Project_Focal Cryotherapy for the Treatment of Localized Adenocarcinoma of the Prostate. Role: Principal Investigator.
GCO 99-415. Tissue Banking of Prostate, Kidney, Bladder Tissue and Blood.
GCO 03–0962. A Randomized, Double-Blind, Placebo Controlled Phase 3 Trial of Immunotherapy with Autologous Antigen Presenting Cells Loaded with PA2024 (Provenge®, APC8015) in Men with Metastatic, Androgen Independent Prostatic Adenocarcinomas.
GCO 03-0962(2). An Open Label, Single Arm Trial of Immunotherapy with Autologous Antigen Presenting Cells Loaded with PA2024 (APC8015F) for Subjects With Objective Disease Progression and Disease-Related Pain on Trial D9902 Part B (PB01).
GCO 08–0813. A Randomized, Multicenter, Single Blind Study in Men with Metastatic Androgen Independent Prostate Cancer to Evaluate Sipuleucel-T Manufactured with Different Concentrations of PA2024 Antigen (P07-2).
GCO 09–1509. An open label study of sipuleucel-T in men with castrate resistant prostate cancer.
GCO 10–0751. A Phase I Neoadjuvant Study of In-Situ REIC/Dkk-3 Gene Therapy Followed by Prostatectomy in Patients with High Risk of Localized Prostate Cancer (MTG-REIC-PC001).
Book chapters
Alexander C. Small and Michael A Palese. Ethanol Injection of Prostate. Treatment of Benign Prostatic Hyperplasia: Modern Alternative to Transurethral Resection of the Prostate. Springer, New York, 2015: 163-172.
Wedmid A and Palese MA. Complications of Laparoscopic Donor Nephrectomy. Complications of Laparoscopic and Robotic Urologic Surgery. Springer, New York, 2010:127-142.
Palese MA, Del Pizzo JJ, Munver R and Poppas D. Robotic assisted adult and pediatric pyeloplasty. Textbook of Laparoscopic Urology. Informa Healthcare, New York, 2006:303-311.
Palese MA, Mulhall JP and Goldstein I. Surgical treatments for vasculogenic erectile dysfunction. Atlas of Male Sexual Dysfunction. Current Medicine LLC, Philadelphia, 2004:115-125.
Publications
Barman, Naman; Palese, Michael A (March 2016). "Robotic surgery for treatment of chyluria". Journal of Robotic Surgery. 10 (1): 1–4. doi:10.1007/s11701-016-0560-5. PMID26861449.
Finkelstein, Mark; Bilal, Khawaja H; Palese, Michael A (2015). "A Medical Application to Bridge the Gap between Clinicians and Clinical Data". Studies in health technology and informatics. 210: 681–683. PMID25991238.
Jayadevan, R; Stensland, K; Small, A; Hall; Palese, Michael A (October 2014). "A protocol to recover needles lost during minimally invasive surgery". JSLS. 18 (4). doi:10.4293/JSLS.2014.00165. PMID25489212.
Lubezky, Nir; Stern, Eric H.; Nair, Vinay; Herron, Daniel; Chin, Eduard; Palese, Michael A; LaPointe Rudow, Dianne; Delaney, Veronica; Goldstein, Michael; Florman, Sander; Rocca, Juan P (September 2014). "Pulmonary embolus originating from renal vein stump thrombus after laparoscopic living donor nephrectomy: case report". Transplantation Procedures. 46 (7): 2406–2408. doi:10.1016/j.transproceed.2014.01.013. PMID25242795.
Harvey, KA; Palese, Michael A (May 2013). "Ablative Therapies for Small Renal Masses". Contemporary Oncology. 5 (1): 10–14.
Leapman, Michael S; Jibara, Ghalib; Tabrizian, Parissa; Franssen, Bernardo; Yang, Ming-Jim; Romanoff, Anya; Hall, Simon J; Palese, Michael; Sarpel, Umut; Hiotis, Spiros; Labow, Daniel (April 2014). "Genitourinary resection at the time of cytoreductive surgery and heated intraperitoneal chemotherapy for peritoneal carcinomatosis is not associated with increased morbidity or worsened oncologic outcomes: a case-matched study". Annals of Surgical Oncology. 21 (4): 1153–1161. doi:10.1245/s10434-013-3393-8. PMID24322531.
Small, Alexander C; Gainsburg, Daniel M; Mercado, Miguel A; Link, Richard E; Hedican, Sean P; Palese, Michael A (September 2013). "Laparoscopic needle-retrieval device for improving quality of care in minimally invasive surgery". Journal of the American College of Surgeons. 217 (3): 400–405. doi:10.1016/j.jamcollsurg.2013.02.035. PMID23707045.
Chin, EH; Hazzan, D; Edye, M; Wisnivesky, JP; Herron, DM; Ames, SA; Palese, MA; Pomp, A; Gagner, M; Bromberg, JS (July 2009). "The first decade of a laparoscopic donor nephrectomy program: effect of surgeon and institution experience with 512 cases from 1996 to 2006". J Am Coll Surg. 209 (1): 106–113. doi:10.1016/j.jamcollsurg.2009.02.060. PMID19651070.
Maniar, KP; Kalir, TL; Palese, MA; Unger, PD (2009). "Endosalpingiosis of the Urinary Bladder: A Case of Probable Implantative Origin With Characterization of Benign Fallopian Tube Immunohistochemistry". Int J Surg Pathol. 18 (5): 381–3. doi:10.1177/1066896909332730. PMID19282293. S2CID30517521.
Mufarrij, PW; Woods, M; Shah, OD; Palese, MA; Berger, AD; Thomas, R; Stifelman, MD (October 2008). "Robotic dismembered pyleoplasty: A 6-year, multi-institutional experience". J. Urol. 180 (4): 1391–1396. doi:10.1016/j.juro.2008.06.024. PMID18707739.
Muller, A; Akin-Olugbade, Y; Deveci, S; Donohue, JF; Tal, R; Kobylarz, KA; Palese, M; Mulhall, JP (2008). "The Impact of Shock Wave Therapy at Varied Energy and Dose Levels on Functional and Structural Changes in Erectile Tissue". Eur Urol. 53 (3): 635–642. doi:10.1016/j.eururo.2007.06.032. PMID17618733.
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