MicroRNA 138-1

MIR138-1
Identifiers
Aliases	MIR138-1 , MIRN138-1, mir-138-1, microRNA 138-1
External IDs	OMIM: 613394; GeneCards: MIR138-1; OMA:MIR138-1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	44,114,310 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; blood; ; upper lobe of left lung; ; intestine; ; monocyte; ; corpus callosum; ; left adrenal gland; ; left lobe of thyroid gland; ; Amygdala; ; human kidney;
	n/a
	More reference expression data
	n/a
Orthologs
	406929
	n/a
	ENSG00000207954
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated January 04, 2025

MicroRNA 138-1 is an protein that in humans is encoded by the MIR138-1 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Related Research Articles

In molecular biology, miR-137 is a short non-coding RNA molecule that functions to regulate the expression levels of other genes by various mechanisms. miR-137 is located on human chromosome 1p22 and has been implicated to act as a tumor suppressor in several cancer types including colorectal cancer, squamous cell carcinoma and melanoma via cell cycle control.

In molecular biology mir-22 microRNA is a short RNA molecule. MicroRNAs are an abundant class of molecules, approximately 22 nucleotides in length, which can post-transcriptionally regulate gene expression by binding to the 3' UTR of mRNAs expressed in a cell.

In molecular biology, mir-221 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-138 is a family of microRNA precursors found in animals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-138 precursor is the microRNA mir-138.

In molecular biology mir-497 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-25 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-25 levels increase in human heart failure, and treatment with an anti-sense RNA molecule (antagomiR) was recently reported to halt disease progression and improves cardiac function in a mouse heart failure model.

In molecular biology mir-154 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-185 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-708 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-708 is located on chromosome 11q14.1 and is endcoded in intron 1 of the ODZ4 gene. It is most highly expressed in the brain and eyes, and has a supposed role in endoplasmic reticular stress of the eye.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 1271 is a microRNA that in humans is encoded by the MIR1271 gene.

MicroRNA 503 is a non-coding RNA molecule that in humans is encoded by the MIR503 gene.

MicroRNA 499a is a non-coding RNA that in humans is encoded by the MIR499A gene.

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene.

MicroRNA 195 is a microRNA that in humans is encoded by the MIR195 gene.

MicroRNA 124-3 is a protein that in humans is encoded by the MIR124-3 gene.

miR-324-5p is a microRNA that functions in cell growth, apoptosis, cancer, epilepsy, neuronal differentiation, psychiatric conditions, cardiac disease pathology, and more. As a microRNA, it regulates gene expression through targeting mRNAs. Additionally, miR-324-5p is both an intracellular miRNA, meaning it is commonly found within the microenvironment of the cell, and one of several circulating miRNAs found throughout the body. Its presence throughout the body both within and external to cells may contribute to miR-324-5p's wide array of functions and role in numerous disease pathologies – especially cancer – in various organ systems.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000207954 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 138-1" . Retrieved 2016-11-17.

Liu X, Jiang L, Wang A, Yu J, Shi F, Zhou X (2009). "MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines". Cancer Lett. 286 (2): 217–22. doi:10.1016/j.canlet.2009.05.030. PMC 2783372 . PMID 19540661.
Jiang L, Dai Y, Liu X, Wang C, Wang A, Chen Z, Heidbreder CE, Kolokythas A, Zhou X (2011). "Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma". Hum. Genet. 129 (2): 189–97. doi:10.1007/s00439-010-0915-3. PMC 3121246 . PMID 21079996.
Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent AY, Bak M, Kauppinen S, Kassem M (2011). "MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo". Proc. Natl. Acad. Sci. U.S.A. 108 (15): 6139–44. Bibcode:2011PNAS..108.6139E. doi: 10.1073/pnas.1016758108 . PMC 3076836 . PMID 21444814.
Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T (2011). "MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression". Mol. Cancer Res. 9 (8): 1100–11. doi:10.1158/1541-7786.MCR-11-0007. PMC 3157593 . PMID 21693595.
Song T, Zhang X, Wang C, Wu Y, Cai W, Gao J, Hong B (2011). "MiR-138 suppresses expression of hypoxia-inducible factor 1α (HIF-1α) in clear cell renal cell carcinoma 786-O cells". Asian Pac. J. Cancer Prev. 12 (5): 1307–11. PMID 21875287.
Liu X, Lv XB, Wang XP, Sang Y, Xu S, Hu K, Wu M, Liang Y, Liu P, Tang J, Lu WH, Feng QS, Chen LZ, Qian CN, Bei JX, Kang T, Zeng YX (2012). "MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene". Cell Cycle. 11 (13): 2495–506. doi: 10.4161/cc.20898 . PMID 22739938.
Yamasaki T, Seki N, Yamada Y, Yoshino H, Hidaka H, Chiyomaru T, Nohata N, Kinoshita T, Nakagawa M, Enokida H (2012). "Tumor suppressive microRNA‑138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma". Int. J. Oncol. 41 (3): 805–17. doi:10.3892/ijo.2012.1543. PMC 3582944 . PMID 22766839.
Ramachandran S, Karp PH, Jiang P, Ostedgaard LS, Walz AE, Fisher JT, Keshavjee S, Lennox KA, Jacobi AM, Rose SD, Behlke MA, Welsh MJ, Xing Y, McCray PB (2012). "A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator". Proc. Natl. Acad. Sci. U.S.A. 109 (33): 13362–7. Bibcode:2012PNAS..10913362R. doi: 10.1073/pnas.1210906109 . PMC 3421220 . PMID 22853952.
Girgis AH, Iakovlev VV, Beheshti B, Bayani J, Squire JA, Bui A, Mankaruos M, Youssef Y, Khalil B, Khella H, Pasic M, Yousef GM (2012). "Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma". Cancer Res. 72 (20): 5273–84. doi: 10.1158/0008-5472.CAN-12-0656 . PMID 22926558.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000207954 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 138-1" . Retrieved 2016-11-17.

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[3]

MicroRNA 138-1

Contents

Function

Related Research Articles

References

Further reading