MicroRNA 148a

MIR148A
Identifiers
Aliases	MIR148A , MIRN148, MIRN148A, hsa-mir-148, mir-148a, microRNA 148a
External IDs	OMIM: 613786 GeneCards: MIR148A
Gene location (Human)
Chr.	Chromosome 7 (human)
End	25,949,986 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; blood; ; body of pancreas; ; monocyte; ; left ventricle; ; stomach; ; body of stomach; ; fundus; ; endometrium; ; uterine tube;
	n/a
	More reference expression data
	n/a
Orthologs
	406940
	n/a
	ENSG00000199085
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated December 04, 2023

MicroRNA 148a is a miRNA that in humans is encoded by the MIR148A gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Related Research Articles

In molecular biology mir-126 is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several pre- and post-transcription mechanisms.

In molecular biology, miR-137 is a short non-coding RNA molecule that functions to regulate the expression levels of other genes by various mechanisms. miR-137 is located on human chromosome 1p22 and has been implicated to act as a tumor suppressor in several cancer types including colorectal cancer, squamous cell carcinoma and melanoma via cell cycle control.

In molecular biology mir-143 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir–143 is highly conserved in vertebrates. mir-143 is thought be involved in cardiac morphogenesis but has also been implicated in cancer.

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology, the miR-200 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by binding and cleaving mRNAs or inhibiting translation. The miR-200 family contains miR-200a, miR-200b, miR-200c, miR-141, and miR-429. There is growing evidence to suggest that miR-200 microRNAs are involved in cancer metastasis.

In molecular biology miR-205 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. They are involved in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes.

miR-138 is a family of microRNA precursors found in animals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-138 precursor is the microRNA mir-138.

In molecular biology mir-488 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-542 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-615 microRNA is a short non-coding RNA molecule belonging both to the family of microRNAs and to that of small interfering RNAs (siRNAs). MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma.

MicroRNA 34a (miR-34a) is a MicroRNA that in humans is encoded by the MIR34A gene.

DNA methylation in cancer plays a variety of roles, helping to change the healthy cells by regulation of gene expression to a cancer cells or a diseased cells disease pattern. One of the most widely studied DNA methylation dysregulation is the promoter hypermethylation where the CPGs islands in the promoter regions are methylated contributing or causing genes to be silenced.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 503 is a non-coding RNA molecule that in humans is encoded by the MIR503 gene.

MicroRNA 499a is a non-coding RNA that in humans is encoded by the MIR499A gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 200c is a microRNA that in humans is encoded by the MIR200C gene.

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene.

MicroRNA 124-3 is a protein that in humans is encoded by the MIR124-3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000199085 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 148a" . Retrieved 2017-09-08.

Fujita Y, Kojima K, Ohhashi R, Hamada N, Nozawa Y, Kitamoto A, Sato A, Kondo S, Kojima T, Deguchi T, Ito M (2010). "MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression". J. Biol. Chem. 285 (25): 19076–84. doi: 10.1074/jbc.M109.079525 . PMC 2885186 . PMID 20406806.
Hummel R, Hussey DJ, Michael MZ, Haier J, Bruewer M, Senninger N, Watson DI (2011). "MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma". Ann. Surg. Oncol. 18 (1): 253–60. doi:10.1245/s10434-010-1213-y. PMID 20628822. S2CID 26439245.
Haflidadóttir BS, Bergsteinsdóttir K, Praetorius C, Steingrímsson E (2010). "miR-148 regulates Mitf in melanoma cells". PLOS ONE. 5 (7): e11574. Bibcode:2010PLoSO...511574H. doi: 10.1371/journal.pone.0011574 . PMC 2904378 . PMID 20644734.
Murata T, Takayama K, Katayama S, Urano T, Horie-Inoue K, Ikeda K, Takahashi S, Kawazu C, Hasegawa A, Ouchi Y, Homma Y, Hayashizaki Y, Inoue S (2010). "miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression". Prostate Cancer Prostatic Dis. 13 (4): 356–61. doi:10.1038/pcan.2010.32. PMID 20820187.
Giraud-Triboult K, Rochon-Beaucourt C, Nissan X, Champon B, Aubert S, Piétu G (2011). "Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1" (PDF). Physiol. Genomics. 43 (2): 77–86. doi:10.1152/physiolgenomics.00077.2010. PMID 21081659.
Muiños-Gimeno M, Espinosa-Parrilla Y, Guidi M, Kagerbauer B, Sipilä T, Maron E, Pettai K, Kananen L, Navinés R, Martín-Santos R, Gratacòs M, Metspalu A, Hovatta I, Estivill X (2011). "Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways". Biol. Psychiatry. 69 (6): 526–33. doi: 10.1016/j.biopsych.2010.10.010 . PMID 21168126. S2CID 206101163.
Pavicic W, Perkiö E, Kaur S, Peltomäki P (2011). "Altered methylation at microRNA-associated CpG islands in hereditary and sporadic carcinomas: a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach". Mol. Med. 17 (7–8): 726–35. doi:10.2119/molmed.2010.00239. PMC 3146601 . PMID 21327300.
Zhang H, Li Y, Huang Q, Ren X, Hu H, Sheng H, Lai M (2011). "MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer". Cell Death Differ. 18 (11): 1702–10. doi:10.1038/cdd.2011.28. PMC 3190106 . PMID 21455217.
Kulkarni S, Savan R, Qi Y, Gao X, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, Carrington M (2011). "Differential microRNA regulation of HLA-C expression and its association with HIV control". Nature. 472 (7344): 495–8. Bibcode:2011Natur.472..495K. doi:10.1038/nature09914. PMC 3084326 . PMID 21499264.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000199085 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 148a" . Retrieved 2017-09-08.

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[3]

MicroRNA 148a

Contents

Function

Related Research Articles

References

Further reading