MicroRNA 210

MIR210
Identifiers
Aliases	MIR210 , MIRN210, mir-210, microRNA 210, MIRN210 microRNA, human
External IDs	OMIM: 612982; GeneCards: MIR210; OMA:MIR210 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	568,198 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; skin of leg; ; skin of abdomen; ; mucosa of esophagus; ; olfactory zone of nasal mucosa; ; vagina; ; urinary bladder; ; mucosa of transverse colon; ; skeletal muscle tissue; ; endometrium;
	n/a
	More reference expression data
	n/a
Orthologs
	406992
	n/a
	ENSG00000199038
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated November 07, 2024

MicroRNA 210 is a protein that in humans is encoded by the MIR210 gene. ^[3]

Function

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Related Research Articles

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments are approximately 20–25 base pairs long with a two-base overhang on the 3′-end. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component Argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA).

Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA gene. It is the primary nuclease that executes the initiation step of miRNA processing in the nucleus. It works closely with DGCR8 and in correlation with Dicer. It has been found significant in clinical knowledge for cancer prognosis. and HIV-1 replication.

In molecular biology mir-210 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.

MicroRNA 34a (miR-34a) is a microRNA that in humans is encoded by the MIR34A gene.

MicroRNA 138-1 is a protein that in humans is encoded by the MIR138-1 gene.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 503 is a non-coding RNA molecule that in humans is encoded by the MIR503 gene.

MicroRNA 203a is a small RNA that in humans is encoded by the preMIR203A gene.

MicroRNA 494 is a microRNA sequence which is encoded in humans by the MIR494 gene.

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

MicroRNA 196b is a protein that in humans is encoded by the MIR196B gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 195 is a microRNA that in humans is encoded by the MIR195 gene.

MicroRNA 885 is a protein that in humans is encoded by the MIR885 gene.

MicroRNA 223 is a protein that in humans is encoded by the MIR223 gene.

MicroRNA 517c is a protein that in humans is encoded by the MIR517C gene.

MicroRNA 93 is a functional RNA and a microRNA that in humans is encoded by the MIR93 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000199038 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 210" . Retrieved 2018-06-08.

Greither T, Grochola LF, Udelnow A, Lautenschläger C, Würl P, Taubert H (January 2010). "Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival". Int. J. Cancer. 126 (1): 73–80. doi: 10.1002/ijc.24687 . PMID 19551852.
Zhang Z, Sun H, Dai H, Walsh RM, Imakura M, Schelter J, Burchard J, Dai X, Chang AN, Diaz RL, Marszalek JR, Bartz SR, Carleton M, Cleary MA, Linsley PS, Grandori C (September 2009). "MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT". Cell Cycle. 8 (17): 2756–68. doi: 10.4161/cc.8.17.9387 . PMID 19652553.
Bianchi N, Zuccato C, Lampronti I, Borgatti M, Gambari R (August 2009). "Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression". BMB Rep. 42 (8): 493–9. doi: 10.5483/bmbrep.2009.42.8.493 . PMID 19712585.
Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ (September 2009). "Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation". Mol. Cell. 35 (6): 856–67. doi:10.1016/j.molcel.2009.09.006. PMC 2782615 . PMID 19782034.
Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J (October 2009). "MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2". Cell Metab. 10 (4): 273–84. doi:10.1016/j.cmet.2009.08.015. PMC 2759401 . PMID 19808020.
Bostjancic E, Zidar N, Glavac D (2009). "MicroRNA microarray expression profiling in human myocardial infarction". Dis. Markers. 27 (6): 255–68. doi: 10.1155/2009/641082 . PMC 3834671 . PMID 20075508.
Gee HE, Camps C, Buffa FM, Patiar S, Winter SC, Betts G, Homer J, Corbridge R, Cox G, West CM, Ragoussis J, Harris AL (May 2010). "hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer". Cancer. 116 (9): 2148–58. doi: 10.1002/cncr.25009 . PMID 20187102. S2CID 29964899.
Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, Meenakshisundaram G, Kuppusamy P, Friedman A, Sen CK (April 2010). "Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds". Proc. Natl. Acad. Sci. U.S.A. 107 (15): 6976–81. doi: 10.1073/pnas.1001653107 . PMC 2872456 . PMID 20308562.
Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, Crosby M, Devlin C, Blick C, Buffa F, Li JL, Vojnovic B, Pires das Neves R, Glazer P, Iborra F, Ivan M, Ragoussis J, Harris AL (April 2010). "MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU". PLOS ONE. 5 (4): e10345. Bibcode:2010PLoSO...510345F. doi: 10.1371/journal.pone.0010345 . PMC 2859946 . PMID 20436681.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000199038 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 210" . Retrieved 2018-06-08.

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[3]

MicroRNA 210

Contents

Function

Related Research Articles

References

Further reading