MicroRNA 4521

MIR4521
Identifiers
Aliases	MIR4521 , mir-4521, microRNA 4521
External IDs	GeneCards: MIR4521
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,187,004 bp
RNA expression pattern
	Top expressed in
	blood; ; sural nerve; ; bone marrow; ; monocyte; ; muscle of leg; ; gastrocnemius muscle; ; endometrium; ; Achilles tendon; ; lymph node; ; liver;
	n/a
	More reference expression data
	n/a
Orthologs
	100616406
	n/a
	ENSG00000283160
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated October 14, 2022

MicroRNA 4521 is a micro RNA that in humans is encoded by the MIR4521 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

miR-4521 has been shown to have decreased expression in various cancers, including breast cancer and lung cancer. In gastric carcinoma, miR-4521 has been reported to inhibit EMT and metastasis.^[4]

Related Research Articles

MicroRNA 4640 is a non-coding RNA in humans that is encoded by the MIR4640 gene.

MicroRNA 1269a is a protein that in humans is encoded by the MIR1269A gene.

MicroRNA 627 is a protein that in humans is encoded by the MIR627 gene.

MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.

MicroRNA 222 is a MicroRNA that in humans is encoded by the MIR222 gene, and is a known extracellular RNA (exRNA).

MicroRNA 133a-1 is a MicroRNA that in humans is encoded by the MIR133A1 gene, and is a known extracellular RNA (exRNA).

MicroRNA 361 is a micro RNA that in humans is encoded by the MIR361 gene.

MicroRNA 5008 is a protein that in humans is encoded by the MIR5008 gene.

MicroRNA let-7a-2 is a ncRNA that in humans is encoded by the MIRLET7A2 gene.

MicroRNA 5680 is a protein that in humans is encoded by the MIR5680 gene.

MicroRNA 3173 is a protein that in humans is encoded by the MIR3173 gene.

MicroRNA 486-1 is a functional RNA that in humans is encoded by the MIR486-1 gene.

MicroRNA 7-2 is a non-protein-coding gene product that in humans is encoded by the MIR7-2 gene.

MicroRNA 1271 is a microRNA that in humans is encoded by the MIR1271 gene.

MicroRNA 6850 is a protein that in humans is encoded by the MIR6850 gene.

MicroRNA 548v is a protein that in humans is encoded by the MIR548V gene.

MicroRNA 196b is a protein that in humans is encoded by the MIR196B gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene.

MicroRNA 195 is a protein that in humans is encoded by the MIR195 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000283160 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 4521" . Retrieved 2016-03-08.
↑ Xing S, Tian Z, Zheng W, Yang W, Du N, Gu Y, et al. (January 2021). "Hypoxia downregulated miR-4521 suppresses gastric carcinoma progression through regulation of IGF2 and FOXM1". Molecular Cancer. 20 (1): 9. doi:10.1186/s12943-020-01295-2. PMC 7786912 . PMID 33407516.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000283160 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 4521" . Retrieved 2016-03-08.

[4] Xing S, Tian Z, Zheng W, Yang W, Du N, Gu Y, et al. (January 2021). "Hypoxia downregulated miR-4521 suppresses gastric carcinoma progression through regulation of IGF2 and FOXM1". Molecular Cancer. 20 (1): 9. doi:10.1186/s12943-020-01295-2. PMC 7786912 . PMID 33407516.

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