MicroRNA 93

MIR93
Identifiers
Aliases	MIR93 , MIRN9, MIRN93, hsa-mir-93, miR-93, microRNA 93
External IDs	OMIM: 612984 GeneCards: MIR93
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,093,847 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; skeletal muscle tissue; ; endometrium; ; sural nerve; ; blood; ; rectum; ; lymph node; ; placenta; ; monocyte; ; stomach;
	n/a
	More reference expression data
	n/a
Orthologs
	407050
	n/a
	ENSG00000207757
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated December 03, 2023

MicroRNA 93 is a functional RNA and a microRNA that in humans is encoded by the MIR93 gene. ^[3]

Function

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70 nucleotide long stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target messenger RNAs (mRNA) through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.^[4]

Related Research Articles

microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene.

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology miR-205 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. They are involved in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes.

In molecular biology mir-301 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.

MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.

MicroRNA 34a (miR-34a) is a MicroRNA that in humans is encoded by the MIR34A gene.

MicroRNA 138-1 is a protein that in humans is encoded by the MIR138-1 gene.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 494 is a microRNA sequence which is encoded in humans by the MIR494 gene.

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

MicroRNA 196b is a protein that in humans is encoded by the MIR196B gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 200c is a microRNA that in humans is encoded by the MIR200C gene.

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene.

MicroRNA 195 is a protein that in humans is encoded by the MIR195 gene.

MicroRNA 210 is a protein that in humans is encoded by the MIR210 gene.

MicroRNA 124-3 is a protein that in humans is encoded by the MIR124-3 gene.

MicroRNA 517c is a protein that in humans is encoded by the MIR517C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000207757 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 93" . Retrieved 2018-10-24.
↑ RefSeq, Sep 2009

Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I, Iliopoulos D, Pilozzi E, Liu CG, Negrini M, Cavazzini L, Volinia S, Alder H, Ruco LP, Baldassarre G, Croce CM, Vecchione A (March 2008). "E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer". Cancer Cell. 13 (3): 272–86. doi: 10.1016/j.ccr.2008.02.013 . PMID 18328430.
Yeung ML, Yasunaga J, Bennasser Y, Dusetti N, Harris D, Ahmad N, Matsuoka M, Jeang KT (November 2008). "Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1". Cancer Res. 68 (21): 8976–85. doi:10.1158/0008-5472.CAN-08-0769. PMC 2596768 . PMID 18974142.
Li Y, Tan W, Neo TW, Aung MO, Wasser S, Lim SG, Tan TM (July 2009). "Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma". Cancer Sci. 100 (7): 1234–42. doi: 10.1111/j.1349-7006.2009.01164.x . PMID 19486339. S2CID 39583369.
Du L, Schageman JJ, Subauste MC, Saber B, Hammond SM, Prudkin L, Wistuba II, Ji L, Roth JA, Minna JD, Pertsemlidis A (August 2009). "miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1". Mol. Cancer Res. 7 (8): 1234–43. doi:10.1158/1541-7786.MCR-08-0507. PMC 2741087 . PMID 19671678.
Shen J, DiCioccio R, Odunsi K, Lele SB, Zhao H (February 2010). "Novel genetic variants in miR-191 gene and familial ovarian cancer". BMC Cancer. 10: 47. doi: 10.1186/1471-2407-10-47 . PMC 2831822 . PMID 20167074.
Roccaro AM, Sacco A, Jia X, Azab AK, Maiso P, Ngo HT, Azab F, Runnels J, Quang P, Ghobrial IM (September 2010). "microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia". Blood. 116 (9): 1506–14. doi:10.1182/blood-2010-01-265686. PMC 2938840 . PMID 20519629.
Hu Z, Shu Y, Chen Y, Chen J, Dong J, Liu Y, Pan S, Xu L, Xu J, Wang Y, Dai J, Ma H, Jin G, Shen H (March 2011). "Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival". Am. J. Respir. Crit. Care Med. 183 (5): 641–8. doi:10.1164/rccm.201005-0717OC. PMID 20889907.
Fang L, Deng Z, Shatseva T, Yang J, Peng C, Du WW, Yee AJ, Ang LC, He C, Shan SW, Yang BB (February 2011). "MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8". Oncogene. 30 (7): 806–21. doi: 10.1038/onc.2010.465 . PMID 20956944.
Choi OR, Lim IK (April 2011). "Loss of p21(Sdi1) expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21(Sdi1) gene promoter". Biochem. Biophys. Res. Commun. 407 (2): 406–11. doi:10.1016/j.bbrc.2011.03.038. PMID 21402054.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000207757 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 93" . Retrieved 2018-10-24.

[4] RefSeq, Sep 2009

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MicroRNA 93

Contents

Function

Related Research Articles

References

Further reading