Micropolygyria

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Micropolygyria
Other namesPolymicrogyria, Polygyria, or Microgyria
Specialty Neurology

Micropolygyria is a neuronal migration disorder, a developmental anomaly of the brain characterized by development of numerous small convolutions (microgyri), causing intellectual disability and/or other neurological disorders. [1] It is present in a number of specific neurological diseases, notably multiple sclerosis and Fukuyama congenital muscular dystrophy, a specific disease cause by mutation in the Fukutin gene (FKTN). [2] [3]

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References

  1. ↑ Dorland's Illustrated Medical Dictionary Merck Archived 2007-10-11 at the Wayback Machine .
  2. ↑ Murakami T, Hayashi YK, Noguchi S, et al. (November 2006). "Fukutin gene mutations cause dilated cardiomyopathy with minimal muscle weakness". Ann. Neurol. 60 (5): 597–602. doi: 10.1002/ana.20973 . PMID   17036286.
  3. ↑ Brockington M, Blake DJ, Prandini P, et al. (December 2001). "Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan". Am. J. Hum. Genet. 69 (6): 1198–209. doi:10.1086/324412. PMC   1235559 . PMID   11592034.


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