Mir-663 microRNA precursor family

mir-663
Identifiers
Symbol	mir-663
Rfam	RF00957
miRBase family	MIPF0000462
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Gastric cancer suppression

miR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer cell lines. Its introduction into the two human gastric cancer cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation. ^[1] Transfection with miR-663 also sees a resultant upregulation of cyclin B.

miR-155 upregulation and other molecular targets

Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells. ^[2] Endogenous activator protein-1 (AP-1) activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipopolysaccharide upregulation of miR-155 by resveratrol. ^[3] miR-663 also directly targets EEF1A2, translation elongation factor and well-known protooncogene. ^{[2] [4]}

See also

• MicroRNA

References

1. Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, Sun L, Liu J, Yang Z, Ran Y (July 2010). "Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells". Oncology Reports. 24 (1): 105–12. doi: 10.3892/or_00000834 . PMID   20514450.
2. Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I (June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC   3681015 . PMID   23695020.
3. Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (September 2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–6. doi:10.1093/carcin/bgq143. PMC   4647642 . PMID   20622002.
4. Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM (July 2002). "Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer". Nature Genetics. 31 (3): 301–5. doi:10.1038/ng904. PMID   12053177. S2CID   37997742.

Further reading

• Liang P, Lv C, Jiang B, Long X, Zhang P, Zhang M, Xie T, Huang X (June 2012). "MicroRNA profiling in denatured dermis of deep burn patients". Burns. 38 (4): 534–40. doi:10.1016/j.burns.2011.10.014. PMID   22360957.
• Lu J, Kwan BC, Lai FM, Tam LS, Li EK, Chow KM, Wang G, Li PK, Szeto CC (May 2012). "Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis". Nephrology. 17 (4): 346–51. doi:10.1111/j.1440-1797.2012.01573.x. PMID   22295894. S2CID   24163790.
• Yi C, Wang Q, Wang L, Huang Y, Li L, Liu L, Zhou X, Xie G, Kang T, Wang H, Zeng M, Ma J, Zeng Y, Yun JP (October 2012). "MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma". Oncogene. 31 (41): 4421–33. doi: 10.1038/onc.2011.629 . PMID   22249270.
• Yang Y, Wang LL, Li YH, Gao XN, Liu Y, Yu L (February 2012). "Effect of CpG island methylation on microRNA expression in the k-562 cell line". Biochemical Genetics. 50 (1–2): 122–34. doi:10.1007/s10528-011-9478-9. PMID   22089542. S2CID   16736093.
• Marques FZ, Campain AE, Tomaszewski M, Zukowska-Szczechowska E, Yang YH, Charchar FJ, Morris BJ (December 2011). "Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs". Hypertension. 58 (6): 1093–8. doi: 10.1161/HYPERTENSIONAHA.111.180729 . PMID   22042811.
• Borgan E, Navon R, Vollan HK, Schlichting E, Sauer T, Yakhini Z, Lingjærde OC, Sørlie T, Børresen-Dale AL (December 2011). "Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue". Molecular Oncology. 5 (6): 564–76. doi:10.1016/j.molonc.2011.08.004. PMC   5528325 . PMID   21917534.
• Tili E, Michaille JJ (2011). "Resveratrol, MicroRNAs, Inflammation, and Cancer". Journal of Nucleic Acids. 2011: 102431. doi: 10.4061/2011/102431 . PMC   3154569 . PMID   21845215.
• Yang Y, Wang LL, Li YH, Gao XN, Yu L (April 2011). "[Expression level of miRNA-663 in different leukemic cell lines and its biological function]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 19 (2): 279–83. PMID   21518471.
• Jian P, Li ZW, Fang TY, Jian W, Zhuan Z, Mei LX, Yan WS, Jian N (April 2011). "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663". Journal of Hematology & Oncology. 4: 20. doi: 10.1186/1756-8722-4-20 . PMC   3094392 . PMID   21518431.
• Ni CW, Qiu H, Jo H (May 2011). "MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells". American Journal of Physiology. Heart and Circulatory Physiology. 300 (5): H1762-9. doi:10.1152/ajpheart.00829.2010. PMC   3094086 . PMID   21378144.
• Potapova A, Albat C, Hasemeier B, Haeussler K, Lamprecht S, Suerbaum S, Kreipe H, Lehmann U (January 2011). "Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution". BMC Biotechnology. 11: 6. doi: 10.1186/1472-6750-11-6 . PMC   3032674 . PMID   21235780.
• Liu ZY, Zhang GL, Wang MM, Xiong YN, Cui HQ (2011). "MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation". Asian Pacific Journal of Cancer Prevention. 12 (11): 2819–23. PMID   22393947.
• Dreher A, Rossing M, Kaczkowski B, Nielsen FC, Norrild B (December 2010). "Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR". Biochemical and Biophysical Research Communications. 403 (3–4): 357–62. doi:10.1016/j.bbrc.2010.11.035. PMID   21078297.
• Tili E, Michaille JJ, Alder H, Volinia S, Delmas D, Latruffe N, Croce CM (December 2010). "Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells". Biochemical Pharmacology. 80 (12): 2057–65. doi:10.1016/j.bcp.2010.07.003. PMC   3918904 . PMID   20637737.
• Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (September 2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–6. doi:10.1093/carcin/bgq143. PMC   4647642 . PMID   20622002.
• Marasa BS, Srikantan S, Martindale JL, Kim MM, Lee EK, Gorospe M, Abdelmohsen K (June 2010). "MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence". Aging. 2 (6): 333–43. doi:10.18632/aging.100159. PMC   2919253 . PMID   20606251.
• Te JL, Dozmorov IM, Guthridge JM, Nguyen KL, Cavett JW, Kelly JA, Bruner GR, Harley JB, Ojwang JO (May 2010). Means T (ed.). "Identification of unique microRNA signature associated with lupus nephritis". PLOS ONE. 5 (5): e10344. Bibcode:2010PLoSO...510344T. doi: 10.1371/journal.pone.0010344 . PMC   2867940 . PMID   20485490.
• Buratti E, De Conti L, Stuani C, Romano M, Baralle M, Baralle F (May 2010). "Nuclear factor TDP-43 can affect selected microRNA levels". The FEBS Journal. 277 (10): 2268–81. doi: 10.1111/j.1742-4658.2010.07643.x . PMID   20423455.
• Maes OC, Sarojini H, Wang E (October 2009). "Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts". Journal of Cellular Physiology. 221 (1): 109–19. doi:10.1002/jcp.21834. PMID   19475566. S2CID   21566082.
• Pizzimenti S, Ferracin M, Sabbioni S, Toaldo C, Pettazzoni P, Dianzani MU, Negrini M, Barrera G (January 2009). "MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation". Free Radical Biology & Medicine. 46 (2): 282–8. doi:10.1016/j.freeradbiomed.2008.10.035. PMID   19022373.
• Lehmann U, Hasemeier B, Römermann D, Müller M, Länger F, Kreipe H (2007). "[Epigenetic inactivation of microRNA genes in mammary carcinoma]". Verhandlungen der Deutschen Gesellschaft für Pathologie. 91: 214–20. PMID   18314617.
• Lehmann U, Hasemeier B, Christgen M, Müller M, Römermann D, Länger F, Kreipe H (January 2008). "Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer". The Journal of Pathology. 214 (1): 17–24. doi:10.1002/path.2251. PMID   17948228. S2CID   22024957.

External links

• Page for mir-663 microRNA precursor family at Rfam