Moshe Szyf | |
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| Fields | Epigenetics and Cancer research |
Moshe Szyf is a geneticist and James McGill professor of pharmacology and therapeutics at the McGill University, where he also holds a GlaxoSmithKline-CIHR chair in pharmacology.
Szyf's main research interests lie with epigenetics, including behavioral epigenetics as well as cancer research.
Szyf received his Ph.D. from the Hebrew University on basic mechanisms of DNA methylation under the supervision of Aharon Razin. Subsequently, he performed postdoctoral work at Harvard Medical School. In 1989, he was appointed as assistant professor in the department of Pharmacology and Therapeutics at McGill University, Canada. [1] In 2016, Moshe Szyf founded Montreal EpiTerapia Inc. in Canada and HKG Epitherapeutics in Hong Kong in order to develop novel tools for the early detection of cancer and promoting healthy aging.
As of April 2019 [update] , Moshe Szyf published 295 papers in peer-reviewed journals, almost all on epigenetics [2] with a focus on cancer until the early 2000s and mostly environmental factors thereafter. He is a member of the editorial board of the journal Environmental Epigenetics, published by Oxford University Press. [3]
Szyf also holds many patents, all relating to epigenetics-based therapeutics. [4]
In biology, epigenetics are stable heritable traits that cannot be explained by changes in DNA sequence, and the study of a type of stable change in cell function that does not involve a change to the DNA sequence. The Greek prefix epi- in epigenetics implies features that are "on top of" or "in addition to" the traditional genetic mechanism of inheritance. Epigenetics usually involves a change that is not erased by cell division, and affects the regulation of gene expression. Such effects on cellular and physiological phenotypic traits may result from environmental factors, or be part of normal development. They can lead to cancer.
Manel Esteller graduated in medicine from the University of Barcelona in 1992, where he also obtained his doctorate, specializing in the molecular genetics of endometrial carcinoma, in 1996. He was an invited researcher at the School of Biological and Medical Sciences at the University of St Andrews, Scotland, during which time his research interests focused on the molecular genetics of inherited breast cancer.
Sir Adrian Peter Bird, is a British geneticist and Buchanan Professor of Genetics at the University of Edinburgh. Bird has spent much of his academic career in Edinburgh, from receiving his PhD in 1970 to working at the MRC Mammalian Genome Unit and later serving as director of the Wellcome Trust Centre for Cell Biology. His research focuses on understanding DNA methylation and CpG islands, and their role in diseases such as Rett syndrome.
Michael J. Meaney, CM, CQ, FRSC, is a professor at McGill University specializing in biological psychiatry, neurology, and neurosurgery, who is primarily known for his research on stress, maternal care, and gene expression. His research team has "discovered the importance of maternal care in modifying the expression of genes that regulate behavioral and neuroendocrine responses to stress, as well as hippocampal synaptic development" in animal studies. The research has implications for domestic and public policy for maternal support and its role in human disease prevention and economic health.
The Centre for Molecular Medicine and Therapeutics (CMMT) is part of the University of British Columbia's Faculty of Medicine. The Centre is located at the British Columbia Children's Hospital Research Institute (BCCHR) in Vancouver, British Columbia, Canada. Research at CMMT is focused on discovering genetic susceptibility to illnesses such as Huntington Disease, Type 2 diabetes and bipolar disorder.
Tony Kouzarides, FMedSci, FRS is a senior group leader Gurdon Institute, a founding non-executive director of Abcam and a Professor of Cancer Biology at the University of Cambridge.
Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal and human behavior. It seeks to explain how nurture shapes nature, where nature refers to biological heredity and nurture refers to virtually everything that occurs during the life-span. Behavioral epigenetics attempts to provide a framework for understanding how the expression of genes is influenced by experiences and the environment to produce individual differences in behaviour, cognition, personality, and mental health.
Randy Jirtle is an American biologist noted for his research in epigenetics, the branch of biology that deals with inherited information that does not reside in the nucleotide sequence of DNA. Jirtle retired from Duke University, Durham, NC in 2012. He is Professor of Epigenetics in the Department of Biological Sciences at North Carolina State University, Raleigh, NC, and Senior Visiting Scientist at the McArdle Laboratory of Cancer Research, University of Wisconsin, Madison, WI. Jirtle is noted for his research on genomic imprinting, and for his use of the Agouti mouse model to investigate the effect of environmental agents on the mammalian epigenome and disease susceptibility.
Elizabeth Jean Finnegan FAA is an Australian botanist who researches plant flowering processes and epigenetic regulation in plants. She currently works at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) as a senior scientist, leading research on the "Control of Floral Initiation", part of the CSIRO Agriculture Flagship.
Gustavo Turecki is a Canadian psychiatrist, suicidologist, neuroscientist who is a professor at McGill University in Montreal, Quebec, Canada. He holds a Tier 1 Canada Research Chair Tier in Major Depressive Disorder and Suicide. He is the sitting Chair of the Department of Psychiatry at McGill University, the Scientific Director of the Douglas Research Centre, and the Psychiatrist-in-Chief of the Centre intégré universitaire de santé et de services sociaux de l’Ouest-de-l’Île-de-Montréal. He works at the Douglas Mental Health University Institute, where he heads both the McGill Group for Suicide Studies and the Depressive Disorders Program, and is the co-director of the Douglas Bell-Canada Brain Bank.
Epigenetics of depression is the study of how epigenetics contribute to depression.
Frances A. Champagne is a Canadian psychologist and University Professor of Psychology at the University of Texas at Austin known for her research in the fields of molecular neuroscience, maternal behavior, and epigenetics. Research in the Champagne lab explores the developmental plasticity that occurs in response to environmental experiences. She is known for her work on the epigenetic transmission of maternal behavior. Frances Champagne's research has revealed how natural variations in maternal behavior can shape the behavioral development of offspring through epigenetic changes in gene expression in a brain region specific manner. She won the NIH Director's New Innovator Award in 2007 and the Frank A. Beach Young Investigator Award in Behavioral Neuroendocrinology in 2009. She has been described as the "bee's knees of neuroscience". She serves on the Committee on Fostering Healthy Mental, Emotional, and Behavioral Development Among Children and Youth in the United States.
Donald Straley Coffey was the Catherine Iola and J. Smith Michael distinguished professor of urology at Johns Hopkins University School of Medicine and subsequently professor emeritus. He had a primary appointment in urology and secondary appointments in oncology, pharmacology and pathology.
Pharmacoepigenetics is an emerging field that studies the underlying epigenetic marking patterns that lead to variation in an individual's response to medical treatment.
Professor Susan J. Clark is an Australian biomedical researcher in epigenetics of development and cancer. She was elected a Fellow of the Australian Academy of Science in 2015, and is a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellow and Research Director and Head of Genomics and Epigenetics Division at the Garvan Institute of Medical Research. Clark developed the first method for bisulphite sequencing for DNA methylation analysis and used it to establish that the methylation machinery of mammalian cells is capable of both maintenance and de novo methylation at CpNpG sites and showed is inheritable. Clark's research has advanced understanding of the role of DNA methylation, non-coding RNA and microRNA in embryogenesis, reprogramming, stem cell development and cancer and has led to the identification of epigenomic biomarkers in cancer. Clark is a founding member of the International Human Epigenome Consortium (IHEC) and President of the Australian Epigenetics Alliance (AEpiA).
Dr. Freda Miller, FRSC is a developmental neurobiologist at the Hospital for Sick Children Research Institute and a professor at the University of Toronto. Dr. Miller holds a Canada Research Chair in developmental neurobiology and her work focuses on development and regeneration of neurons.
Nadine Provençal is an assistant professor at Simon Fraser University and Investigator at BC Children's Hospital Research Institute. In 2020, she was recognized by the Canadian Institute for Advanced Research (CIFAR) with an appointment to CIFAR Azrieli Global Scholar.
Andrea Baccarelli is an Italian American epigeneticist and clinical endocrinologist, best known for his academic contributions in the field of epigenetics, mitochondriomics, and computational epigenomics, with a research focus on investigating the impact of environmental exposures on human health. He serves as Professor and Chair of the Department of Environmental Health Sciences at the Columbia University Mailman School of Public Health.
Sarah Kimmins is a Canadian scientist whose research explores the role of epigenetics in germ cell development, fertility and offspring health. She is a professor in epigenomics, development and disease at the University of Montreal, in the Department of Pathology and Cellular Biology, in the Faculty of Medicine and is Senior Group Leader at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal.
Matthias Schwab is a German doctor and university lecturer. He is director of the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology located on the campus of the Robert-Bosch-Hospital in Stuttgart, an institution of the Robert Bosch Stiftung, and holder of the Chair of Clinical Pharmacology at the University of Tübingen as well as Medical Director of the Department of Clinical Pharmacology at the University Hospital Tübingen.
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