Murphy Roths large

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Murphy Roths large (MRL/MpJ) is a strain of laboratory mouse developed in 1999 at The Wistar Institute in Philadelphia, Pennsylvania. [1] Originally bred for autoimmune disease research, it was discovered to have remarkable tissue regeneration abilities. [2] [3] [4]

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Research

The MRL/MpJ mouse strain was selectively bred by scientists to have an autoimmune genetic disorder (retained through inbreeding) to be used as a model for autoimmune disease research. [1] After making puncture wounds in their ears, these mice were observed to completely regenerate from these wounds without development of scar tissue. [1] [2] In further research, this mouse strain has been observed to have the ability to also regenerate cardiac tissue, displays a resistance to muscle dystrophy, and is resistant to experiencing hyperglycemia from a diet high in fats. [5] [6] [7]

Related Research Articles

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With physical trauma or disease suffered by an organism, healing involves the repairing of damaged tissue(s), organs and the biological system as a whole and resumption of (normal) functioning. Medicine includes the process by which the cells in the body regenerate and repair to reduce the size of a damaged or necrotic area and replace it with new living tissue. The replacement can happen in two ways: by regeneration in which the necrotic cells are replaced by new cells that form "like" tissue as was originally there; or by repair in which injured tissue is replaced with scar tissue. Most organs will heal using a mixture of both mechanisms.

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References

  1. 1 2 3 Clark, Lise Desquenne; Clark, Robert K.; Heber-Katz, Ellen (July 1998). "A New Murine Model for Mammalian Wound Repair and Regeneration". Clinical Immunology and Immunopathology. 88 (1): 35–45. doi:10.1006/clin.1998.4519. ISSN   0090-1229. PMID   9683548. S2CID   3734804.
  2. 1 2 Heber-Katz, E.; Leferovich, J. M.; Bedelbaeva, K.; Gourevitch, D. (2004). "Spallanzani's mouse: a model of restoration and regeneration". Current Topics in Microbiology and Immunology. 280: 165–89. doi:10.1007/978-3-642-18846-6_5. ISBN   978-3-642-62321-9. PMID   14594211.
  3. Morelle, Rebecca (11 April 2006). "Mouse sheds light on regeneration". BBC News .
  4. Carswell, Lindsay (18 April 2006). "Self-healing Mice". ScienCentral News. Archived from the original on 20 October 2008.
  5. Heber-Katz, Ellen; Leferovich, John M.; Bedelbaeva, Khamilia (2001-12-01). "Spontaneous heart regeneration in adult MRL mice after cryoinjury". Gene Therapy and Regulation. 1 (4): 399–407. doi:10.1163/156855801760107055. ISSN   1568-5586.
  6. Heydemann, Ahlke; Swaggart, Kayleigh; Kim, Gene H; Holley-Cuthrell, Jenan; Hadhazy, Michele; McNally, Elizabeth M (2012). "The superhealing MRL background improves muscular dystrophy". Skeletal Muscle. 2 (1): 26. doi: 10.1186/2044-5040-2-26 . ISSN   2044-5040. PMC   3534636 . PMID   23216833.
  7. Mull, Aaron J.; Berhanu, Tirsit K.; Roberts, Nathan W.; Heydemann, Ahlke (December 2014). "The Murphy Roths Large (MRL) mouse strain is naturally resistant to high fat diet-induced hyperglycemia". Metabolism. 63 (12): 1577–1586. doi:10.1016/j.metabol.2014.09.007. ISSN   0026-0495. PMC   4252560 . PMID   25308446.