NBR2

Last updated
neighbor of BRCA1 gene 2
Identifiers
SymbolNBR2
NCBI gene 10230
HGNC 20691
RefSeq NM_005821
Other data
Locus Chr. 17 q21

NBR2 is a gene best known for its location near the breast cancer associated gene BRCA1. [1] Like BRCA1, NBR2 has been a subject of research, [2] but links to breast cancer are currently inconclusive.

NBR2 recently was identified as a glucose starvation-induced long non-coding RNA. NBR2 interacts with AMP-activated protein kinase (AMPK), a critical energy sensor in most eukaryotic cells, and promotes AMPK function to mediate energy stress response. Knockdown of NBR2 attenuates energy stress-induced AMPK activation, resulting in unchecked cell cycling, altered apoptosis/autophagy response, and increased tumour development in vivo. [3] [4] It is now appreciated that NBR2, a former junk gene, plays critical roles in tumor suppression. [5]

References

  1. ↑ Xu CF, Brown MA, Nicolai H, Chambers JA, Griffiths BL, Solomon E (1997). "Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene". Hum. Mol. Genet. 6 (7): 1057–62. doi: 10.1093/hmg/6.7.1057 . PMID   9215675.
  2. ↑ Auriol E, Billard LM, Magdinier F, Dante R (2005). "Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus". Nucleic Acids Res. 33 (13): 4243–54. doi:10.1093/nar/gki729. PMC   1181861 . PMID   16052033.
  3. ↑ Liu, Xiaowen; Xiao, Zhen-Dong; Han, Leng; Zhang, Jiexin; Lee, Szu-Wei; Wang, Wenqi; Lee, Hyemin; Zhuang, Li; Chen, Junjie (2016-04-01). "LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress". Nature Cell Biology. 18 (4): 431–442. doi:10.1038/ncb3328. ISSN   1476-4679. PMC   4814347 . PMID   26999735.
  4. ↑ Liu, Xiaowen; Xiao, Zhen-Dong; Gan, Boyi (2016-08-02). "An lncRNA switch for AMPK activation". Cell Cycle. 15 (15): 1948–1949. doi:10.1080/15384101.2016.1184515. ISSN   1551-4005. PMC   4968966 . PMID   27152502.
  5. ↑ Xiao, Zhen-Dong; Liu, Xiaowen; Zhuang, Li; Gan, Boyi (2016-07-03). "NBR2: A former junk gene emerges as a key player in tumor suppression". Molecular & Cellular Oncology. 3 (4) e1187322. doi:10.1080/23723556.2016.1187322. PMC   4972102 . PMID   27652330.



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