NUDT12

NUDT12
Identifiers
Aliases	NUDT12 , nudix hydrolase 12
External IDs	OMIM: 609232 MGI: 1915243 HomoloGene: 44188 GeneCards: NUDT12
Gene location (Human)
Chr.	Chromosome 5 (human) [1]
End	103,562,790 bp [1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse) [2]
End	59,013,372 bp [2]
Gene ontology
Molecular function	• NAD+ diphosphatase activity ; • GO:0001948 protein binding ; • hydrolase activity ; • metal ion binding ; • NADH pyrophosphatase activity ;
Cellular component	• cytoplasm ; • peroxisome ; • cell nucleus ; • peroxisomal matrix ; • cytosol ;
Biological process	• NAD catabolic process ; • NADP catabolic process ; • NAD biosynthesis via nicotinamide riboside salvage pathway ; • NADH metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	83594
	67993
	ENSG00000112874
	ENSMUSG00000024228
	Q9BQG2
	Q9DCN1
	NM_001300741 ; NM_031438
	NM_026497 ; NM_001368393
	NP_001287670 ; NP_113626
	NP_080773 ; NP_001355322
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 21, 2020

Peroxisomal NADH pyrophosphatase NUDT12 is an enzyme that in humans is encoded by the NUDT12 gene.^[5]^[6]

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors.

Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003).[supplied by OMIM]^[6]

Related Research Articles

Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an enzyme that in humans is encoded by the NUDT21 gene. It belongs to the Nudix family of hydrolases.

REX2, RNA exonuclease 2 homolog , also known as REXO2, is an enzyme which in humans is encoded by the REXO2 gene.

RNA exonuclease 4 is an enzyme that in humans is encoded by the REXO4 gene.

Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.

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Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene.

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KATNBL1 is a protein that in humans is encoded by the KATNBL1 gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112874 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024228 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
1 2 "Entrez Gene: NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Abdelraheim SR, Spiller DG, McLennan AG (2003). "Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein". Biochem. J. 374 (Pt 2): 329–35. doi:10.1042/BJ20030441. PMC 1223609 . PMID 12790796.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112874 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024228 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.

[entrez-6] 1 2 "Entrez Gene: NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12".

NUDT12

Related Research Articles

References

Further reading