Nathaniel David

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Nathaniel David
Nathaniel David 2.jpg
Born
San Francisco, California, U.S.
Nationality American
Alma mater Harvard University, University of California, Berkeley
Known forKythera Biopharmaceuticals, Kybella, Jupiter Bioventures
AwardsMIT Technology Review Young Innovators Under 35
Scientific career
Fields Biotechnology
InstitutionsKythera Biopharmaceuticals, Unity Biotechnology, Jupiter Bioventures

Nathaniel David is an American scientist and biotechnology entrepreneur who has co-founded several life sciences companies that together have raised more than $1.5 billion in financing and contributed to the development of multiple FDA-approved medicines, including alogliptin , trelagliptin , Zemiglo (Zemdi) , Zemdri , and Kybella .

Contents

Biography

Education and Career

David earned an A.B. in Biology from Harvard University and a Ph.D. in Molecular and Cellular Biology from University of California, Berkeley . [1] While completing his doctorate, he co-founded Syrrx in 1999. The company developed a high-throughput structural biology platform that used automation and miniaturization to accelerate protein structure determination. [2] [3] David was named to the MIT Technology Review TR35, a list of top global innovators under the age of 35. Syrrx was acquired by Takeda Pharmaceutical Company in 2005, and its research contributed to the development of Nesina (alogliptin), a diabetes drug approved by the FDA. [4] [5]

David later co-founded Achaogen (NASDAQ: AKAO), focused on developing treatments for antibiotic-resistant infections. Achaogen developed Zemdri (plazomicin), which was approved by the FDA for complicated urinary tract infections.

In 2005, David co-founded Kythera Biopharmaceticals (NASDAQ: KYTH), where he served as Chief Science Officer. The company developed Kybella, the first FDA-approved injectable drug for reducing submental fat. [6] Kythera went public in 2012 and was acquired by Allergan in 2015 for $2.1 billion. [7] [8]

In 2011, he also co-founded UNITY Biotechnology (NASDAQ: UBX). [9] [10] [11] [12] [13]

Recent Work

In 2021, David co-founded Jupiter Bioventures with former National Cancer Institute director Ned Sharpless . Jupiter Bioventures is a venture foundry that supports the development of therapeutic companies based on emerging biological science. It launched with an initial fund of $70 million and focuses on areas such as oncology and immunology.


References

  1. ↑ "Biotech on brink of breakthroughs". SFGate. 22 February 2004. Retrieved 2016-03-09.
  2. ↑ Pollack, Andrew (2000-07-04). "Analyzing Proteins With X-Rays, Crystals and Some Luck". The New York Times. ISSN   0362-4331 . Retrieved 2016-03-09.
  3. ↑ Pollack, Andrew (2000-07-04). "The Next Chapter in the Book of Life Is Written in the Proteins". The New York Times. ISSN   0362-4331 . Retrieved 2016-03-09.
  4. ↑ Pollack, Andrew (2005-04-20). "Some in Biotech Prefer an Acquisition to an I.P.O." The New York Times. ISSN   0362-4331 . Retrieved 2016-03-09.
  5. ↑ Parsa, Kishore Vl; Pal, Manojit (2011-08-01). "Preclinical development of dipeptidyl peptidase IV inhibitor alogliptin: a brief overview". Expert Opinion on Drug Discovery. 6 (8): 855–869. doi:10.1517/17460441.2011.588695. ISSN   1746-045X. PMID   22651127. S2CID   24271265.
  6. ↑ "FDA approves treatment for fat below the chin" (Press release). U.S. Food and Drug Administration. April 29, 2015. Archived from the original on 2015-05-01. Retrieved 2016-03-09.
  7. ↑ Sachetta, Ryan. "Allergan to Buy Kythera Biopharmaceuticals for $2.1 Billion". Bloomberg.com. Retrieved 2016-03-09.
  8. ↑ "Top 10 biotech IPOs of 2012". FierceBiotech. Retrieved 2016-03-09.
  9. ↑ "Backed by a lineup of marquee VCs, Unity Biotechnology tackles the hard science of aging". FierceBiotech. Retrieved 2016-03-09.
  10. ↑ "Unity SEC S-1 Form". April 5, 2018. Retrieved 2018-11-14– via sec.gov.
  11. ↑ "Mayo Clinic Taps Silicon Valley to Help People Age Gracefully". Fortune. Retrieved 2016-03-09.
  12. ↑ Yong, Ed (3 February 2016). "Clearing the Body's Retired Cells Slows Aging and Extends Life". The Atlantic. Retrieved 2016-03-09.
  13. ↑ "Boosting Life Span By Clearing Out Cellular Clutter". NPR.org. Retrieved 2016-03-09.
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