Nicholas Theodore

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Nicholas Theodore
Nicholas Theodore at Johns Hopkins Hospital.jpg
Nicholas Theodore at Johns Hopkins Hospital
Born
San Diego, California
NationalityGreek
Alma mater Cornell University
Georgetown University School of Medicine
AwardsMayfield Award (CNS), Tasker Award (CNS), "Teacher of the Year" (BNI, 2007, 2014), US News "Top Docs," Cornell Tradition Academic Fellowship
Scientific career
FieldsTrauma Neurosurgery, Spine, Robotics, Spinal Cord Injury
InstitutionsJohns Hopkins University

Nicholas Theodore is an American neurosurgeon and researcher at Johns Hopkins University School of Medicine. He is known for his work in spinal trauma, minimally invasive surgery, robotics, and personalized medicine. He is Director of the Neurosurgical Spine Program at Johns Hopkins and Co-Director of the Carnegie Center for Surgical Innovation at Johns Hopkins.

Contents

Dr. Theodore graduated from Cornell University, where he was the recipient of a Cornell Tradition Academic Fellowship. He attended medical school at Georgetown University, where he graduated with honors. After completing his internship at Bethesda Naval Hospital, Dr. Theodore served as a Senior General Medical Officer with the United States Marine Corps in Okinawa, Japan.

Dr. Theodore completed his neurosurgical residency and a fellowship in spinal surgery at the Barrow Neurological Institute. [1] After completing his residency in 2001, he served as Chief of the Division of Neurosurgery at Naval Medical Center San Diego, overseeing the largest neurosurgery complement in the Navy.

In 2003, Dr. Theodore joined the faculty at the Barrow Neurological Institute, and assumed the position of Director of Neurotrauma. In 2004 he was appointed Associate Director of the Neurosurgery Residency Program at Barrow. The Neurosurgery Residency Program at Barrow is the largest in the United States, training four residents per academic year, [2] for a total of 28 residents. In 2009 he became the Chief of the Spine Section at the Barrow Neurological Institute and was appointed the Volker K.H. Sonntag Chair in 2015. In 2016 he became the second Donlin M. Long Professor of Neurosurgery at Johns Hopkins Hospital. Dr. Theodore also holds professorships in Orthopedics and Biomedical Engineering at Johns Hopkins. He is also actively involved in the area of preventative medicine within neurosurgery. He has been associated with the ThinkFirst Foundation for several years, having served as the foundation’s Medical Director and President. In 2017, Dr. Theodore was appointed to the National Football League’s Head, Neck and Spine Committee, of which he became Chairman in 2018. [3] In 2020, Michael J. Fox revealed in his memoir that Dr. Theodore performed a risky but successful surgery on him to remove an ependymoma in Fox’s spinal cord. [4] [5]

Research

Dr. Theodore's main research focus is on complex spinal disorders, spinal cord injury, and advanced surgical technologies. He has published over 300 peer-reviewed articles and book chapters, and has given more than 300 technical presentations. He is the recipient of several awards, including the Mayfield Award and the Tasker Award from the Congress of Neurological Surgeons, as well as being named in "US News Top Docs". [6] He was one of the senior investigators in a multi-center study that tested a new medication for patients with spinal cord injury. Dr. Theodore has received an NIH RO-1 grant [7] to study novel approaches to spinal surgery, as well as the development of customized devices for patients with spinal cord injury. [2] Less than 10% of these grants are funded nationally.

In 2014, Dr. Theodore was the recipient of a United States Department of Defense grant to conduct a multi-center study evaluating the drainage of cerebrospinal fluid to treat of acute spinal cord injury. In 2010, Dr. Theodore founded Excelsius Surgical along with Neil Crawford and Mitch Foster, focusing on the development of a mobile real-time image-guided robot for spinal, brain, and biopsy applications. He sold Excelsius Surgical to Globus Medical four years later. In August 2017, the Globus Medical ExcelsiusGPS [8] robot received 510k clearance by the FDA and Dr. Theodore performed the first case in the world on October 4, 2017. [9]

In 2020, Dr. Theodore, and his team, received a grant in the amount of $13.48 million from the Defense Advanced Research Projects Agency’s (DARPA) Bridging the Gap+ program to fund research in new approaches to treatment of spinal cord injury. With this grant, Dr. Theodore, and his team, including biomedical engineer, Dr. Amir Manbachi, are pioneering futuristic efforts to treat patients with spinal cord injury by integrating novel imaging and therapeutic ultrasound and electrical modalities. [10] [11] As part of this program, Dr. Theodore, and Dr. Manbachi work alongside a world-class team of experts, including teams at Johns Hopkins Engineering, Applied Physics Laboratory, Columbia University, and Sonic Concepts. [12] [13] [14] [15]

In 2020, Dr. Theodore published the largest series of patients who had undergone vertebral column shortening for tethered spinal cord syndrome. This article, which has the longest follow-up of other published series, established this procedure as a viable alternative to standard interventions. [16] In 2023, the team received the FDA's 'Breakthrough Device Designation' for implantable ultrasound sensors for patients with spinal cord injury. [17] [18]

Dr. Theodore joined the medical advisory board for Harvard MedTech, which specializes in developing new treatments that combine Virtual reality, behavioral health coaching and Artificial intelligence algorithms to retrain neural pathways within the brain. [19] [20] [21]

Recent publications

Related Research Articles

<span class="mw-page-title-main">Neurosurgery</span> Medical specialty of disorders which affect any portion of the nervous system

Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty concerned with the surgical treatment of disorders which affect any portion of the nervous system including the brain, spinal cord and peripheral nervous system.

<span class="mw-page-title-main">Syringomyelia</span> Disorder in which a cyst forms in the spinal cord

Syringomyelia is a generic term referring to a disorder in which a cyst or cavity forms within the spinal cord. Often, syringomyelia is used as a generic term before an etiology is determined. This cyst, called a syrinx, can expand and elongate over time, destroying the spinal cord. The damage may result in loss of feeling, paralysis, weakness, and stiffness in the back, shoulders, and extremities. Syringomyelia may also cause a loss of the ability to feel extremes of hot or cold, especially in the hands. It may also lead to a cape-like bilateral loss of pain and temperature sensation along the upper chest and arms. The combination of symptoms varies from one patient to another depending on the location of the syrinx within the spinal cord, as well as its extent.

<span class="mw-page-title-main">Spinal cord injury</span> Injury to the main nerve bundle in the back of humans

A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. Symptoms may include loss of muscle function, sensation, or autonomic function in the parts of the body served by the spinal cord below the level of the injury. Injury can occur at any level of the spinal cord and can be complete, with a total loss of sensation and muscle function at lower sacral segments, or incomplete, meaning some nervous signals are able to travel past the injured area of the cord up to the Sacral S4-5 spinal cord segments. Depending on the location and severity of damage, the symptoms vary, from numbness to paralysis, including bowel or bladder incontinence. Long term outcomes also range widely, from full recovery to permanent tetraplegia or paraplegia. Complications can include muscle atrophy, loss of voluntary motor control, spasticity, pressure sores, infections, and breathing problems.

<span class="mw-page-title-main">Cervical fracture</span> Medical condition

A cervical fracture, commonly called a broken neck, is a fracture of any of the seven cervical vertebrae in the neck. Examples of common causes in humans are traffic collisions and diving into shallow water. Abnormal movement of neck bones or pieces of bone can cause a spinal cord injury, resulting in loss of sensation, paralysis, or usually death soon thereafter, primarily via compromising neurological supply to the respiratory muscles as well as innervation to the heart.

<span class="mw-page-title-main">Arachnoiditis</span> Inflammation of the arachnoid mater

Arachnoiditis is an inflammatory condition of the arachnoid mater or 'arachnoid', one of the membranes known as meninges that surround and protect the nerves of the central nervous system, including the brain and spinal cord. The arachnoid can become inflamed because of adverse reactions to chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, complications from spinal surgery or other invasive spinal procedures, or the accidental intrathecal injection of steroids intended for the epidural space. Inflammation can sometimes lead to the formation of scar tissue and adhesion that can make the spinal nerves "stick" together, a condition where such tissue develops in and between the leptomeninges. The condition is extremely painful, especially when progressing to adhesive arachnoiditis. Another form of the condition is arachnoiditis ossificans, in which the arachnoid becomes ossified, or turns to bone, and is thought to be a late-stage complication of the adhesive form of arachnoiditis.

<span class="mw-page-title-main">Spinal fusion</span> Immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies

Spinal fusion, also called spondylodesis or spondylosyndesis, is a neurosurgical or orthopedic surgical technique that joins two or more vertebrae. This procedure can be performed at any level in the spine and prevents any movement between the fused vertebrae. There are many types of spinal fusion and each technique involves using bone grafting—either from the patient (autograft), donor (allograft), or artificial bone substitutes—to help the bones heal together. Additional hardware is often used to hold the bones in place while the graft fuses the two vertebrae together. The placement of hardware can be guided by fluoroscopy, navigation systems, or robotics.

Tethered cord syndrome (TCS) refers to a group of neurological disorders that relate to malformations of the spinal cord. Various forms include tight filum terminale, lipomeningomyelocele, split cord malformations (diastematomyelia), occult, dermal sinus tracts, and dermoids. All forms involve the pulling of the spinal cord at the base of the spinal canal, literally a tethered cord. The spinal cord normally hangs loose in the canal, free to move up and down with growth, and with bending and stretching. A tethered cord, however, is held taut at the end or at some point in the spinal canal. In children, a tethered cord can force the spinal cord to stretch as they grow. In adults the spinal cord stretches in the course of normal activity, usually leading to progressive spinal cord damage if untreated. TCS is often associated with the closure of a spina bifida. It can be congenital, such as in tight filum terminale, or the result of injury later in life.

<span class="mw-page-title-main">Neurointensive care</span> Branch of medicine that deals with life-threatening diseases of the nervous system

Neurocritical care is a medical field that treats life-threatening diseases of the nervous system and identifies, prevents, and treats secondary brain injury.

Joshua B. Bederson is an American neurosurgeon, Leonard I. Malis, MD/Corinne and Joseph Graber Professor of Neurosurgery, and Chair of Neurosurgery at the Mount Sinai Health System in New York City. He is a Fellow of the American College of Surgeons and an attending neurosurgeon at The Mount Sinai Hospital and Elmhurst Hospital in Elmhurst, Queens.

Piezoelectric bone surgery is a process that utilizes piezoelectric vibrations in the application of cutting bone tissue. The process was patented by Fernando Bianchetti, Domenico Vercellotti, and Tomaso Vercellotti. It was first used clinically in 1988. It is indicated for use in oral, maxillofacial, cranial and spinal procedures; but is mainly used in orthodontics and craniofacial surgery.

<span class="mw-page-title-main">Roger Härtl</span> American neurosurgeon

Roger Härtl is an American neurological surgeon at Weill-Cornell Medical College and NewYork-Presbyterian Hospital. He is Director of Spinal Surgery at the Weill Cornell Brain & Spine Center. Härtl has been named by Becker's Spine Review as one of the Top 50 Spine Surgeons in the United States as well as one of the Top 10 Spine and Neurosurgeon Leaders at Non-Profit Hospitals. He was named one of New York's Top Doctors by New York Magazine after he saved the life of New York firefighter Eugene Stolowski.

<span class="mw-page-title-main">Barrow Neurological Institute</span> Hospital in Arizona, United States

Barrow Neurological Institute is the world's largest neurological disease treatment and research institution, and is consistently ranked as one of the best neurosurgical training centers in the United States. Founded in 1962, the main campus is located at 350 W. Thomas Road, Phoenix, Arizona.

Curtis Dickman is an American Neurosurgeon at Barrow Neurological Institute, and is recognized internationally for his pioneering work in the field of Thoracoscopic Neurosurgery. He serves as Director of the Spine Research Laboratory and Associate Chief of the Spine Section at Barrow Neurological Institute.

Arthur L. Jenkins III is an American fellowship-trained neurosurgeon, co-director of the Neurosurgical Spine Program, and Director of Spinal Oncology and Minimally Invasive Spinal Surgery (MIS) Program at the Mount Sinai Hospital, New York. Additionally, he is an associate professor of Neurosurgery and of Orthopedic Surgery at the Mount Sinai School of Medicine. Dr. Jenkins has multiple patents and patent applications for spine-related implants and support systems, and is developing new minimally invasive treatments for patients with cancer that has spread to the spine. He is an innovator in the treatment of acute spinal cord injury as well as degenerative and congenital anomalies of the spine, taking a minimally invasive or minimal-impact approach where possible. He is board certified in Neurological Surgery and is licensed in New York and Connecticut.

Spinal cord injury without radiographic abnormality (SCIWORA) is symptoms of a spinal cord injury (SCI) with no evidence of injury to the spinal column on X-rays or CT scan. Symptoms may include numbness, weakness, abnormal reflexes, or loss of bladder or bowel control. Neck or back pain is also common. Symptoms may be brief or persistent. Some do not develop symptoms until a few days after the injury.

Branko Kopjar is a physician and epidemiologist at the University of Washington. He is best known for his contributions in the 1990s to the field of injury prevention and his later work on spine, orthopedic and spinal cord injury research. In addition, he has been published in several top journals in the fields of cardiology, oncology, public health and neurosurgery resulting in a total of more than 500 articles, reports, reviews and abstracts.

Neuroplastic or neuroplastic and reconstructive surgery is the surgical specialty involved in reconstruction or restoration of patients who undergo surgery of the central or peripheral nervous system. The field includes a wide variety of surgical procedures that seek to restore or replace a patient's skull, face, scalp, dura, the spine and/or its overlying tissues.

Alexander Coon is an American neurosurgeon who is the Director of Endovascular and Cerebrovascular Neurosurgery at the Carondelet Neurological Institute of St. Joseph's and St. Mary's Hospitals in Tucson, Arizona. He was previously the Director of Endovascular Neurosurgery at the Johns Hopkins Hospital and an Assistant Professor of Neurosurgery, Neurology, and Radiology at the Johns Hopkins Hospital. He is known for his work in cerebrovascular and endovascular neurosurgery and his research in neuroendovascular devices and clinical outcomes in the treatment of cerebral aneurysms, subarachnoid hemorrhage, and AVMs.

<span class="mw-page-title-main">Bizhan Aarabi</span> Iranian-American neurosurgeon

Bizhan Aarabi is an Iranian-American neurosurgeon, researcher, author, and academic. He is a professor of neurosurgery at University of Maryland and the Director of Neurotrauma at the R Adams Cowley Shock Trauma Center.

Marjorie Wang is an American neurosurgeon, researcher, and academic. She is a professor of Neurosurgery and Director of the Complex Spine Fellowship Program at the Medical College of Wisconsin.

References

  1. "Barrow Neurological Institute".
  2. 1 2 "Barrow Research" (PDF). Archived from the original (PDF) on 2018-01-30.
  3. "National Football League's Head, Neck, Spine Committee". 19 April 2018.
  4. "Michael J. Fox Deals With a Serious Medical Condition". 18 November 2020.
  5. "Michael J. Fox is Grateful and Impressed".
  6. "US News Top Docs".
  7. "NIH".
  8. "Innovation in Musculoskeletal Solutions Globus Medical".
  9. "Johns Hopkins Surgeons Perform First Time Image Guided Spine Surgery".
  10. Condon, Alan (12 October 2020). "Johns Hopkins surgeons awarded $13M+ to develop ultrasound devices for spinal cord injury". beckersspine.com.
  11. "Cross-disciplinary team will design, develop devices to better treat spinal cord injuries". Spinal Cord Injury Zone!. November 11, 2020.
  12. "DARPA Press Release".
  13. "JHU DARPA Press Release". 12 October 2020.
  14. "Focused Ultrasound for Spinal Cord Injury: Johns Hopkins Receives Funding for New Device". October 30, 2020.
  15. "$13.48M Awarded To Johns Hopkins Scientists To Develop Implantable Ultrasound Devices For Patients With Spinal Cord Injury". newswise.com.
  16. Theodore, Nicholas; Cottrill, Ethan; Kalb, Samuel; Zygourakis, Corinna; Jiang, Bowen; Pennington, Zach; Lubelski, Daniel; Westbroek, Erick M.; Ahmed, A Karim; Ehresman, Jeff; Sciubba, Daniel M.; Witham, Timothy F.; Turner, Jay D.; Groves, Mari; Kakarla, U Kumar (March 2021). "Vertebral Column Shortening for Tethered Cord". Neurosurgery. pp. 637–647. doi:10.1093/neuros/nyaa491. PMC   7884146 . PMID   33372221.
  17. Morris, Shaun. "FDA Breakthrough Device Designation for Implantable Ultrasound Sensor for Patients With Spinal Cord Injury | HEPIUS". www.hopkinsmedicine.org. Retrieved 2023-01-29.
  18. Morris, Shaun. "HEPIUS Lab | Johns Hopkins Neurology and Neurosurgery". www.hopkinsmedicine.org. Retrieved 2023-01-29.
  19. "Lauded Neurosurgeon, Researcher and Inventor Nicholas Theodore, MD Joins Harvard MedTech's Medical Advisory Board". www.businesswire.com. 2023-01-10. Retrieved 2023-01-29.
  20. Behm, Carly (10 January 2023). "Dr. Nicholas Theodore joins Harvard MedTech medical advisory board". www.beckersspine.com. Retrieved 2023-01-29.
  21. "Lauded Neurosurgeon, Researcher and Inventor Nicholas Theodore, MD Joins Harvard MedTech's Medical Advisory Board". autos.yahoo.com. Retrieved 2023-01-29.