Ole Kiehn

Last updated
Ole Kiehn
Ole Kiehn 11.jpg
Danish - Swedish neuroscientist
Born1958 (age 66–67)
Nakskov, Denmark
NationalityDanish-Swedish
Occupation(s) Neuroscientist and professor

Ole Kiehn (born 1958) is a Danish-Swedish neuroscientist. [1] He is Professor of Integrative Neuroscience at the Department of Neuroscience, University of Copenhagen, Denmark, and professor of neurophysiology at Karolinska Institute, Sweden. [2] [3]

Contents

Early life and education

Kiehn was born 1958 in Nakskov, Denmark. He earned his medical degree in 1985 and his Doctorate in Science (D.Sci.) in 1990, both from the University of Copenhagen. [1]

Career

From 1985-89 Kiehn worked as a research associate at the Institute of Neurophysiology, University of Copenhagen. [1] He spent 1989-90 working as a Postdoc at the Section of Neurobiology and Behavior at Cornell University, US, before returning to Denmark to become a group leader at the Institute of Neurophysiology at University of Copenhagen (1991–95). From 1995 to 2000, he was employed as a Hallas Møller Research Fellow at Department of Physiology, University of Copenhagen, and in 1997 he became associate professor at the same place, a position that he held until he was recruited to Karolinska Institute in Sweden in 2001. Since 2004, Ole Kiehn is working as professor in neuroscience at the Department of Neuroscience at Karolinska Institute. From 2003 to 2011 he was deputy chair of the Department of Neuroscience, Karolinska Institute. In 2008 Kiehn became a member of the Nobel Assembly at the Karolinska Institute and after serving as an adjunct member from 2011–14, he was elected as a member of the Nobel Committee for Physiology or Medicine in 2014 to 2019. [4] From 2024 - 2026 Ole Kiehn serves as President of Federation of European Neuroscience Societies (FENS). [5]

Since 2017, Ole Kiehn is also employed as professor in Integrative Neuroscience at the Department of Neuroscience, University of Copenhagen. Since 2019, Kiehn is co-editor in chief of Current Opinion in Neurobiology. [6]

Work

Kiehn has published over 120 original papers and reviews and his work has been reported in scientific journals, including Nature (journal), Science (journal), Cell (journal), Nature Neuroscience, Neuron (journal), PNAS, Nature Reviews Neuroscience among others. Kiehn's work has elucidated the functional organization of neuronal circuits controlling movement. In his initial work he showed that vertebrate motor neurons can express transmitter-modulated plateau potentials. [7] His continued work has shown an involvement of plateaux in disturbed motor symptoms seen after spinal cord injury. [8] Using molecular mouse genetic, electrophysiology and behavioral studies he has revealed the key cellular organization of spinal locomotor networks and was able to functionally discover and link specific neuronal populations in the spinal cord to the ability to produce the alternating movements between limbs during locomotion [9] [10] [11] [12] and to set the rhythm of locomotion. [13] [14] Kiehn has also discovered specific populations of excitatory brainstem neurons that mediate the episodic control of locomotion: the start and stop of locomotion as well as turning. [13] [15] [16] These studies unravel the communication pathway between the brain and the spinal cord needed to control the expression of locomotion.

Awards and honors

References

  1. 1 2 3 4 5 Kiehn, Ole (October 2, 2017). "CV". in.ku.dk.
  2. ↑ University of Copenhagen, Department of Neuroscience (January 29, 2019). "Kiehn Lab". in.ku.dk.
  3. ↑ "Kiehn Laboratory". ki.se.
  4. ↑ The Nobel Committee for Physiology or Medicine
  5. ↑ "Our Leadership".
  6. ↑ Editorial board of Current Opinion in Neurobiology
  7. ↑ Hounsgaard, J.; Hultborn, H.; Jespersen, B.; Kiehn, O. (November 22, 1988). "Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan". The Journal of Physiology. 405: 345–367. doi:10.1113/jphysiol.1988.sp017336. PMC   1190979 . PMID   3267153.
  8. ↑ Bellardita, C.; Caggiano, V.; Leiras, R.; Caldeira, V.; Fuchs, A.; Bouvier, J.; Löw, P.; Kiehn, O. (2017). "Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice. - PubMed - NCBI". eLife. 6 e23011. doi: 10.7554/eLife.23011 . PMC   5332159 . PMID   28191872.
  9. ↑ Talpalar, Adolfo E.; Endo, Toshiaki; Löw, Peter; Borgius, Lotta; Hägglund, Martin; Dougherty, Kimberly J.; Ryge, Jesper; Hnasko, Thomas S.; Kiehn, Ole (22 September 2011). "Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord. - PubMed - NCBI". Neuron. 71 (6): 1071–1084. doi: 10.1016/j.neuron.2011.07.011 . PMID   21943604. S2CID   16945911.
  10. ↑ Talpalar, Adolfo E.; Bouvier, Julien; Borgius, Lotta; Fortin, Gilles; Pierani, Alessandra; Kiehn, Ole (August 1, 2013). "Dual-mode operation of neuronal networks involved in left-right alternation". Nature. 500 (7460): 85–88. Bibcode:2013Natur.500...85T. doi:10.1038/nature12286. PMID   23812590. S2CID   4427401.
  11. ↑ Butt, Simon J. B.; Kiehn, Ole (June 19, 2003). "Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals". Neuron. 38 (6): 953–963. doi: 10.1016/s0896-6273(03)00353-2 . PMID   12818180. S2CID   17633931.
  12. ↑ Kullander, Klas; Butt, Simon J. B.; Lebret, James M.; Lundfald, Line; Restrepo, Carlos E.; Rydström, Anna; Klein, Rudiger; Kiehn, Ole (March 21, 2003). "Role of EphA4 and EphrinB3 in local neuronal circuits that control walking". Science. 299 (5614): 1889–1892. Bibcode:2003Sci...299.1889K. doi:10.1126/science.1079641. PMID   12649481. S2CID   9275050.
  13. 1 2 Bouvier, Julien; Caggiano, Vittorio; Leiras, Roberto; Caldeira, Vanessa; Bellardita, Carmelo; Balueva, Kira; Fuchs, Andrea; Kiehn, Ole (November 19, 2015). "Descending Command Neurons in the Brainstem that Halt Locomotion". Cell. 163 (5): 1191–1203. doi:10.1016/j.cell.2015.10.074. PMC   4899047 . PMID   26590422.
  14. ↑ Hägglund, Martin; Borgius, Lotta; Dougherty, Kimberly J.; Kiehn, Ole (February 22, 2010). "Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion". Nature Neuroscience. 13 (2): 246–252. doi:10.1038/nn.2482. PMID   20081850. S2CID   5347394.
  15. ↑ Caggiano, V.; Leiras, R.; Goñi-Erro, H.; Masini, D.; Bellardita, C.; Bouvier, J.; Caldeira, V.; Fisone, G.; Kiehn, O. (January 25, 2018). "Midbrain circuits that set locomotor speed and gait selection". Nature. 553 (7689): 455–460. Bibcode:2018Natur.553..455C. doi:10.1038/nature25448. PMC   5937258 . PMID   29342142.
  16. ↑ Cregg, J. M., Leiras, R., Montalant, A., Wanken, P., Wickersham, I. R., Kiehn, O. (1 June 2020). "Brainstem neurons that command mammalian locomotor asymmetries". Nature Neuroscience. 23 (6): 730–740. doi:10.1038/s41593-020-0633-7. ISSN   1546-1726. PMC   7610510 . PMID   32393896.
  17. ↑ "Large grant makes it possible to continue groundbreaking research in the brain". 15 February 2024. Faculty of Health and Medical Sciences News.
  18. ↑ Brain Prize 2022
  19. ↑ "Hjerneforsker hædres for kortlægning af neuronale netværk, der kontrollerer motorik". 8 October 2021.
  20. ↑ University of Copenhagen, Department of Neuroscience (December 20, 2019). "Ole Kiehn receives DKK 32 million to research integrated neural circuits". in.ku.dk.
  21. ↑ "Pioneering Neuroscientist Awarded Novo Nordisk Foundation Laureate Research Grant". Novo Nordisk Foundation News.
  22. ↑ "ERC Advanced Grants 2015 Results" (PDF).
  23. ↑ "EMBO". EMBO.
  24. ↑ "Academy of Europe: Kiehn Ole". www.ae-info.org.
  25. ↑ The Royal Swedish Academy of Sciences homepage
  26. ↑ "Videnskabernes Selskab | Royal Academy". www.royalacademy.dk.
  27. ↑ The Royal Swedish Academy of Sciences News
  28. ↑ "ERC Advanced Grants 2010 - Winners". ERC: European Research Council. January 20, 2011. Archived from the original on February 13, 2020. Retrieved January 10, 2020.
  29. ↑ "IRP Schellenberg Research Prize". www.irp.ch.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.