Oligoporin D

Oligoporin D

Identifiers
IUPAC name (Z,6R)-6-[(3R,5R,10S,12R,13R,14R,17R)-3-oxo-4,4,10,13,14-pentamethyl-12-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,3,5,6,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-methylhept-2-enoic acid
Chemical and physical data
Formula	C36H56O9
Molar mass	632.835 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@]12C[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C3=C(CC[C@@H]4[C@]3(C)CCC(=O)C4(C)C)[C@]2(C)CC[C@@H]1[C@H](C)CC\C=C(\C)C(=O)O

Oligoporin D is a natural product isolated from the "bitter bracket" mushroom Amaropostia stiptica . It was found to be one of the most potent agonists yet discovered for the bitter taste receptor TAS2R46, and consequently one of the most bitter substances known. ^[1]

References

1. Schmitz LM, Lang T, Steuer A, Koppelmann L, Di Pizio A, Arnold N, et al. (February 2025). "Taste-Guided Isolation of Bitter Compounds from the Mushroom Amaropostia stiptica Activates a Subset of Human Bitter Taste Receptors". Journal of Agricultural and Food Chemistry. 73 (8): 4850–4858. Bibcode:2025JAFC...73.4850S. doi:10.1021/acs.jafc.4c12651. PMC   11869282 . PMID   39945763.