TAS2R46 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | TAS2R46 , T2R46, T2R54, taste 2 receptor member 46 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 612774 MGI: 2681256 HomoloGene: 135705 GeneCards: TAS2R46 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Taste receptors for bitter substances (T2Rs/TAS2Rs) belong to the family of G-protein coupled receptors and are related to class A-like GPCRs. There are 25 known T2Rs in humans responsible for bitter taste perception. [5]
Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene. [6] [7]
TAS2R46 gene (Taste receptor type 2 member 46) is a Protein Coding gene. This gene maps to the taste receptor gene cluster on chromosome 12. [8] hTAS2R46 is a bitter receptor broadly tuned to sesquiterpene lactones, related clerodane diterpenoids,labdane diterpenes and more.
In 2022, the solved structure of Tas2r46 [9] was published in the scientific journal Science [10] making it the first Tas2r with a solved structure. The structure of Tas2r46 was solved with cryo-EM and can be downloaded in the Protein Data Bank, under the following names:
7xp6- Cryo-EM structure of a class T GPCR in active state,7xp5- Cryo-EM structure of a class T GPCR in ligand-free state,7xp4- Cryo-EM structure of a class T GPCR in apo state.
There is also a prediction structure available in Alphafold, named Taste receptor type 2 member 46 this is a computational prediction and not an experimental structure.
TAS2R46 was shown to be expressed in other tissues in the human body apart from the oral cavity including human bone marrow stromal-derived cells (MSC) and their relatives, vascular smooth muscle cells (VSMC). [11]
Up to now, 68 ligands were identified for T2R46 and are summarized in [9]
Some of TAS2R46 ligands are approved as drugs [8]
two of the more known ligands of TAS2R46 are Atropine and Strychnine.
Strychnine is known as a strong poison that suppresses the nerve system. Strychnine even makes an appearance in the famous AgathaChristie novel The Mysterious Affair at Styles .
Atropine injection is used to treat heart rate disorders of various types, and is used in drops to treat lazy eye condition.
TAS2R46 was associated with Inflammatory Bowel Disease [12]
Obtained from [9]
Receptor | Location | BW number | Residue | MAF | dbSNP |
TAS2R46 | IC3 | L228M | 0.3359 | rs2708380 |
Known mutations of TAS2R46 include the following: [9]
Receptor | Location | BW number | Residue | References |
TAS2R46 | TM2 | 2.6 | N65 | [13] [14] |
TAS2R46 | TM2 | 2.61 | W66 | [13] [14] [15] |
TAS2R46 | TM2 | 2.64 | T69 | [13] [14] |
TAS2R46 | TM2 | 2.65 | E70 | [13] [15] [14] [16] |
TAS2R46 | EC1 | 2.66 | L71 | [16] [17] |
TAS2R46 | TM3 | 3.26 | I82 | [13] [14] [16] |
TAS2R46 | TM3 | 3.29 | Y85 | [13] [14] |
TAS2R46 | TM3 | 3.3 | N86 | [13] [14] |
TAS2R46 | TM3 | 3.32 | W88 | [13] [14] |
TAS2R46 | TM3 | 3.33 | A89 | [13] [15] [14] |
TAS2R46 | TM3 | 3.36 | N92 | [13] [15] [14] [18] [16] [17] |
TAS2R46 | TM3 | 3.37 | H93 | [13] [15] [14] |
TAS2R46 | TM3 | 3.4 | N96 | [13] [15] [14] |
TAS2R46 | TM4 | 4.6 | I147 | [13] [14] |
TAS2R46 | EC2 | 4.65 | N150 | [16] |
TAS2R46 | EC2 | 4.76 | N161 | [16] |
TAS2R46 | TM5 | 5.38 | S175 | [13] |
TAS2R46 | TM5 | 5.39 | N176 | [13] [15] [14] [16] [17] |
TAS2R46 | TM5 | 5.43 | T180 | [13] [14] |
TAS2R46 | TM5 | 5.47 | N184 | [13] [14] |
TAS2R46 | TM6 | 6.51 | Y241 | [13] [14] [16] [17] |
TAS2R46 | TM6 | 6.52 | F242 | [13] [14] [18] |
TAS2R46 | TM6 | 6.54 | S244 | [13] [14] |
TAS2R46 | TM6 | 6.55 | I245 | [13] [14] |
TAS2R46 | TM6 | 6.58 | S248 | [13] [14] |
TAS2R46 | TM6 | 6.59 | V249 | [13] [14] |
TAS2R46 | EC3 | 6.62 | E253 | [16] |
TAS2R46 | TM7 | 7.35 | E261 | [13] [14] [16] |
TAS2R46 | TM7 | 7.39 | E265 | [13] [15] [14] [16] |
TAS2R46 | TM7 | 7.42 | A268 | [13] [15] [14] [16] |
TAS2R46 | TM7 | 7.43 | F269 | [13] [15] [16] |
TAS2R16 is a bitter taste receptor and one of the 25 TAS2Rs. TAS2Rs are receptors that belong to the G-protein-coupled receptors (GPCRs) family. These receptors detect various bitter substances found in nature as agonists, and get stimulated. TAS2R16 receptor is mainly expressed within taste buds present on the surface of the tongue and palate epithelium. TAS2R16 is activated by bitter β-glucopyranosides
Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the few taste receptors shown to have this function.
Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.
Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.
Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.
Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene. The protein is responsible for bitter taste recognition in mammals. It serves as a defense mechanism to prevent consumption of toxic substances which often have a characteristic bitter taste.
Taste receptors for bitter substances (T2Rs/TAS2Rs) belong to the family of G-protein coupled receptors and are related to class A-like GPCRs. There are 25 known T2Rs in humans responsible for bitter taste perception.
Taste receptor type 1 member 1 is a protein that in humans is encoded by the TAS1R1 gene.
Taste receptor type 1 member 2 is a protein that in humans is encoded by the TAS1R2 gene.
Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene. The TAS1R3 gene encodes the human homolog of mouse Sac taste receptor, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.
Taste receptor type 2 member 39 is a protein that in humans is encoded by the TAS2R39 gene.
Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene.
Taste receptor type 2 member 41 is a protein that in humans is encoded by the TAS2R41 gene.
Taste receptor type 2 member 43 is a protein that in humans is encoded by the TAS2R43 gene.
Taste receptor, type 2, member 31, also known as TAS2R31, is a protein which in humans is encoded by the TAS2R31 gene. This bitter taste receptor has been shown to respond to saccharin in vitro.
Taste receptor type 2 member 45 is a protein that in humans is encoded by the TAS2R45 gene.
Taste receptor type 2 member 30 is a protein that in humans is encoded by the TAS2R30 gene.
Taste receptor type 2 member 19 is a protein that in humans is encoded by the TAS2R19 gene. It seems to be involved in the perception of salt and bitter tastes.
Taste receptor type 2 member 20 is a protein that in humans is encoded by the TAS2R20 gene.
Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.