Neuropeptide Y receptor Y2

Last updated
NPY2R
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NPY2R , NPY2-R, Neuropeptide Y receptor Y2
External IDs OMIM: 162642 MGI: 108418 HomoloGene: 701 GeneCards: NPY2R
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000910
NM_001370180
NM_001375470

NM_001205099
NM_008731

RefSeq (protein)

NP_000901
NP_001357109
NP_001362399

NP_001192028
NP_032757

Location (UCSC) Chr 4: 155.21 – 155.22 Mb Chr 3: 82.45 – 82.46 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene. [5] [6]

Contents

Selective ligands

Agonists

Antagonists

See also

Related Research Articles

<span class="mw-page-title-main">Neuropeptide Y</span> Mammalian protein found in Homo sapiens

Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. It is secreted alongside other neurotransmitters such as GABA and glutamate. 

Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

<span class="mw-page-title-main">Peptide YY</span> Peptide released from cells in the ileum and colon in response to feeding

Peptide YY (PYY), also known as peptide tyrosine tyrosine, is a peptide that in humans is encoded by the PYY gene. Peptide YY is a short peptide released from cells in the ileum and colon in response to feeding. In the blood, gut, and other elements of periphery, PYY acts to reduce appetite; similarly, when injected directly into the central nervous system, PYY is also anorexigenic, i.e., it reduces appetite.

<span class="mw-page-title-main">Glucagon-like peptide-1 receptor</span> Receptor activated by peptide hormone GLP-1

The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesised by the gene GLP1R, which is present on chromosome 6. It is a member of the glucagon receptor family of GPCRs. GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.

<span class="mw-page-title-main">Nociceptin receptor</span> Protein-coding gene in the species Homo sapiens

The nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 gene. The nociceptin receptor is a member of the opioid subfamily of G protein-coupled receptors whose natural ligand is the 17 amino acid neuropeptide known as nociceptin (N/OFQ). This receptor is involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. Antagonists targeting NOP are under investigation for their role as treatments for depression and Parkinson's disease, whereas NOP agonists have been shown to act as powerful, non-addictive painkillers in non-human primates.

<span class="mw-page-title-main">Bombesin-like receptor 3</span> Protein-coding gene in humans

The bombesin receptor subtype 3 also known as BRS-3 or BB3 is a protein which in humans is encoded by the BRS3 gene.

<span class="mw-page-title-main">Prolactin-releasing peptide receptor</span> Protein-coding gene in the species Homo sapiens

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

<span class="mw-page-title-main">Cholecystokinin A receptor</span> Protein-coding gene in the species Homo sapiens

The Cholecystokinin A receptor is a human protein, also known as CCKAR or CCK1, with CCK1 now being the IUPHAR-recommended name.

5-HT<sub>1B</sub> receptor Mammalian protein found in Homo sapiens

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene. The 5-HT1B receptor is a 5-HT receptor subtype.

<span class="mw-page-title-main">Galanin receptor 1</span> Protein-coding gene in the species Homo sapiens

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.

<span class="mw-page-title-main">Melanocortin 3 receptor</span> Mammalian protein found in Homo sapiens

Melanocortin 3 receptor (MC3R) is a protein that in humans is encoded by the MC3R gene.

<span class="mw-page-title-main">Neuropeptide Y receptor Y1</span> Protein-coding gene in the species Homo sapiens

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.

<span class="mw-page-title-main">Neuropeptide Y receptor Y5</span> Protein-coding gene in the species Homo sapiens

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.

<span class="mw-page-title-main">Tachykinin receptor 2</span> Protein-coding gene in the species Homo sapiens

Substance-K receptor is a protein that in humans is encoded by the TACR2 gene.

<span class="mw-page-title-main">Neuropeptide FF receptor 2</span> Protein-coding gene in the species Homo sapiens

Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.

<span class="mw-page-title-main">Melanin-concentrating hormone receptor 2</span> Protein-coding gene in the species Homo sapiens

Melanin-concentrating hormone receptor 2 (MCH2) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.

<span class="mw-page-title-main">Neuromedin U receptor 2</span> Protein-coding gene in the species Homo sapiens

Neuromedin-U receptor 2 is a protein that in humans is encoded by the NMUR2 gene.

<span class="mw-page-title-main">Pancreatic polypeptide receptor 1</span> Protein-coding gene in the species Homo sapiens

Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.

<span class="mw-page-title-main">P2RY4</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.

<span class="mw-page-title-main">Neuropeptide FF</span> Protein-coding gene in the species Homo sapiens

NPFF Neuropeptide FF (FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000185149 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028004 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi: 10.1074/jbc.270.39.22661 . PMID   7559383.
  6. "Entrez Gene: NPY2R neuropeptide Y receptor Y2".
  7. Murphy KG, Dhillo WS, Bloom SR (Dec 2006). "Gut peptides in the regulation of food intake and energy homeostasis". Endocrine Reviews. 27 (7): 719–27. doi:10.1210/er.2006-0028. PMID   17077190. S2CID   24899878.

Further reading