Tachykinin receptor 2

Last updated
TACR2
Identifiers
Aliases TACR2 , NK2R, NKNAR, SKR, TAC2R, Tachykinin receptor 2
External IDs OMIM: 162321; MGI: 98477; HomoloGene: 55548; GeneCards: TACR2; OMA:TACR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001057

NM_009314

RefSeq (protein)

NP_001048

NP_033340

Location (UCSC) Chr 10: 69.4 – 69.42 Mb Chr 10: 62.09 – 62.1 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Substance-K receptor is a protein that in humans is encoded by the TACR2 gene. [5]

Contents

Function

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [5]

Selective Ligands

Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant.

Agonists

Antagonists

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000075073 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020081 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: TACR2 tachykinin receptor 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.