GPR88

GPR88
Identifiers
Aliases	GPR88 , STRG, COCPMR, G protein-coupled receptor 88
External IDs	OMIM: 607468; MGI: 1927653; HomoloGene: 11104; GeneCards: GPR88; OMA:GPR88 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p21.2 Start 100,538,139 bp [1] End 100,542,021 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G1 Start 116,043,303 bp [2] End 116,047,152 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus putamen caudate nucleus nucleus accumbens endothelial cell entorhinal cortex middle temporal gyrus prefrontal cortex right lobe of liver dorsolateral prefrontal cortex Top expressed in olfactory tubercle globus pallidus nucleus accumbens superior frontal gyrus lateral septal nucleus piriform cortex lumbar subsegment of spinal cord temporal lobe barrel cortex primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity cytoskeletal motor activity G protein-coupled receptor activity G protein-coupled photoreceptor activity Cellular component integral component of membrane membrane nucleus cytoplasm plasma membrane cellular component integral component of plasma membrane cilium Biological process locomotory behavior neuromuscular process controlling balance neuronal action potential signal transduction motor learning G protein-coupled receptor signaling pathway neuropeptide signaling pathway chemical synaptic transmission feeding behavior phototransduction detection of visible light cellular response to light stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54112 64378 Ensembl ENSG00000181656 ENSMUSG00000068696 UniProt Q9GZN0 Q9EPB7 RefSeq (mRNA) NM_022049 NM_022427 RefSeq (protein) NP_071332 NP_071872 Location (UCSC) Chr 1: 100.54 – 100.54 Mb Chr 3: 116.04 – 116.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 88 is a protein that in humans is encoded by the GPR88 gene. ^{[5] [6] [7] [8] [9]}

Ligands

Agonists

• RTI-122 ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000181656 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068696 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
6. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
7. Mizushima K, Miyamoto Y, Tsukahara F, et al. (2001). "A novel G-protein-coupled receptor gene expressed in striatum". Genomics. 69 (3): 314–21. doi:10.1006/geno.2000.6340. PMID   11056049.
8. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
9. Van Waes V, Tseng K, Steiner H (2011). "GPR88 - a putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation". Basal Ganglia. 1 (2): 83–89. doi:10.1016/j.baga.2011.04.001. PMC   3144573 . PMID   21804954.
10. Rahman MT, Decker AM, Ben Hamida S, Perrey DA, Chaminda Lakmal HH, Maitra R, Darcq E, Kieffer BL, Jin C (Feb 2023). "Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation". J Med Chem. 66 (4): 2964–2978. doi:10.1021/acs.jmedchem.2c01983. PMC   9974843 . PMID   36749855.