TAAR8

TAAR8
Identifiers
Aliases	TAAR8 , GPR102, TA5, TAR5, TRAR5, TaR-5, TaR-8, trace amine associated receptor 8
External IDs	OMIM: 606927; MGI: 2685995; HomoloGene: 77586; GeneCards: TAAR8; OMA:TAAR8 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q23.2 Start 132,552,693 bp [1] End 132,553,721 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A4 Start 23,967,158 bp [2] End 23,968,192 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreas female reproductive system organ system material anatomical entity kidney renal cortex vagina islet of Langerhans tibial nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function trace-amine receptor activity G protein-coupled receptor activity signal transducer activity Cellular component plasma membrane membrane integral component of membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83551 382348 Ensembl ENSG00000146385 ENSMUSG00000100186 UniProt Q969N4 Q5QD06 RefSeq (mRNA) NM_053278 NM_001010837 RefSeq (protein) NP_444508 NP_001010837 Location (UCSC) Chr 6: 132.55 – 132.55 Mb Chr 10: 23.97 – 23.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene. ^{[5] [6] [7]} In humans, TAAR8 is the only trace amine-associated receptor that is known to be G_i/o-coupled. ^[8]

In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors. ^[9]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins, supplied by OMIM ^[7]

See also

• Trace amine-associated receptor

References

1. GRCh38: Ensembl release 89: ENSG00000146385 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000100186 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, et al. (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID   11574155.
6. Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID   15718104.
7. "Entrez Gene: TAAR8 trace amine associated receptor 8".
8. Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, et al. (November 2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". International Journal of Molecular Sciences. 15 (11): 20638–55. doi: 10.3390/ijms151120638 . PMC   4264187 . PMID   25391046.
9. Izquierdo C, Gómez-Tamayo JC, Nebel JC, Pardo L, Gonzalez A (January 2018). "Identifying human diamine sensors for death related putrescine and cadaverine molecules". PLOS Computational Biology. 14 (1) e1005945. Bibcode:2018PLSCB..14E5945I. doi: 10.1371/journal.pcbi.1005945 . PMC   5783396 . PMID   29324768.

Further reading

• Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 8966–71. Bibcode:2001PNAS...98.8966B. doi: 10.1073/pnas.151105198 . PMC   55357 . PMID   11459929.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.