MRGPRX1

MRGPRX1
Identifiers
Aliases	MRGPRX1 , GPCR, MGRG2, MRGX1, SNSR4, MAS related GPR family member X1
External IDs	OMIM: 607227; MGI: 2441674; HomoloGene: 86246; GeneCards: MRGPRX1; OMA:MRGPRX1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.1|11 Start 18,933,499 bp [1] End 18,939,414 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B4 Start 48,200,713 bp [2] End 48,207,834 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad lower lobe of lung skin of thigh skin of hip liver canal of the cervix skin of abdomen Top expressed in zone of skin lip muscle of thigh white adipose tissue urinary bladder esophagus quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity Cellular component plasma membrane membrane integral component of membrane integral component of plasma membrane cell surface Biological process acute-phase response G protein-coupled receptor signaling pathway signal transduction cell surface receptor signaling pathway response to chloroquine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 259249 243979 Ensembl ENSG00000170255 ENSMUSG00000050425 UniProt Q96LB2 Q3KNA1 RefSeq (mRNA) NM_147199 NM_001393578 NM_175531 RefSeq (protein) NP_671732 NP_780740 Location (UCSC) Chr 11: 18.93 – 18.94 Mb Chr 7: 48.2 – 48.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mas-related G-protein coupled receptor member X1 is a protein that in humans is encoded by the MRGPRX1 gene. ^{[5] [6]}

See also

• MAS1 oncogene

References

1. GRCh38: Ensembl release 89: ENSG00000170255 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050425 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–32. doi: 10.1016/S0092-8674(01)00483-4 . PMID   11551509. S2CID   14119088.
6. "Entrez Gene: MRGPRX1 MAS-related GPR, member X1".

Further reading

• Lembo PM, Grazzini E, Groblewski T, et al. (2002). "Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs". Nat. Neurosci. 5 (3): 201–9. doi:10.1038/nn815. PMID   11850634. S2CID   42544746.
• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. Bibcode:2002FEBSL.520...97T. doi:10.1016/S0014-5793(02)02775-8. PMID   12044878. S2CID   7116392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Galés C, Rebois RV, Hogue M, et al. (2005). "Real-time monitoring of receptor and G-protein interactions in living cells". Nat. Methods. 2 (3): 177–84. doi:10.1038/nmeth743. PMID   15782186. S2CID   22398051.