MRGPRX1

MRGPRX1
Identifiers
Aliases	MRGPRX1 , GPCR, MGRG2, MRGX1, SNSR4, MAS related GPR family member X1
External IDs	OMIM: 607227 MGI: 2441674 HomoloGene: 86246 GeneCards: MRGPRX1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,939,414 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	48,207,834 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; liver; ; canal of the cervix; ; skin of abdomen;
	Top expressed in
	zone of skin; ; lip; ; white adipose tissue; ; urinary bladder; ; esophagus; ; quadriceps femoris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity ; G protein-coupled receptor activity ; transmembrane signaling receptor activity ;
Cellular component	plasma membrane ; membrane ; integral component of membrane ; integral component of plasma membrane ; cell surface ;
Biological process	acute-phase response ; G protein-coupled receptor signaling pathway ; signal transduction ; cell surface receptor signaling pathway ; response to chloroquine ;
	Sources:Amigo / QuickGO
Orthologs
	259249
	243979
	ENSG00000170255
	ENSMUSG00000050425
	Q96LB2
	Q3KNA1
	NM_147199 ; NM_001393578
	NM_175531
	NP_671732
	NP_780740
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Mas-related G-protein coupled receptor member X1 is a protein that in humans is encoded by the MRGPRX1 gene.^[5]^[6]

Related Research Articles

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Mas-related G-protein coupled receptor member D is a protein that in humans is encoded by the MRGPRD gene.

Mas-related G-protein coupled receptor member E is a protein that in humans is encoded by the MRGPRE gene.

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene. It is most abundant on cutaneous mast cells.

Adhesion G-protein coupled receptor A3 (ADGRA3), also known as GPR125, is an adhesion GPCR that in humans is encoded by the Adgra3 gene.

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Mas-related G-protein coupled receptor MRG is a protein that in humans is encoded by the MAS1L gene.

Mas-related G-protein coupled receptor member X3 is a protein that in humans is encoded by the MRGPRX3 gene.

Mas-related G-protein coupled receptor member X4 is a protein that in humans is encoded by the MRGPRX4 gene.

Olfactory receptor 3A2 is a protein that in humans is encoded by the OR3A2 gene.

Olfactory receptor 1E2 is a protein that in humans is encoded by the OR1E2 gene.

Olfactory receptor 2B6 is a protein that in humans is encoded by the OR2B6 gene.

Olfactory receptor 2F1 is a protein that in humans is encoded by the OR2F1 gene.

Olfactory receptor 2L2 is a protein that in humans is encoded by the OR2L2 gene.

Olfactory receptor 7A17 is a protein that in humans is encoded by the OR7A17 gene.

Olfactory receptor 10H3 is a protein that in humans is encoded by the OR10H3 gene.

Olfactory receptor, family 12, subfamily D, member 2, also known as OR12D2, is a protein which in humans is encoded by the OR12D2 gene.

Olfactory receptor 7A5 is a protein that in humans is encoded by the OR7A5 gene.

Olfactory receptor 7C2 is a protein that in humans is encoded by the OR7C2 gene.

Olfactory receptor 2A4 is a protein that in humans is encoded by the OR2A4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170255 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050425 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–32. doi: 10.1016/S0092-8674(01)00483-4 . PMID 11551509. S2CID 14119088.
↑ "Entrez Gene: MRGPRX1 MAS-related GPR, member X1".

Lembo PM, Grazzini E, Groblewski T, et al. (2002). "Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs". Nat. Neurosci. 5 (3): 201–9. doi:10.1038/nn815. PMID 11850634. S2CID 42544746.
Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Galés C, Rebois RV, Hogue M, et al. (2005). "Real-time monitoring of receptor and G-protein interactions in living cells". Nat. Methods. 2 (3): 177–84. doi:10.1038/nmeth743. PMID 15782186. S2CID 22398051.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170255 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050425 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11551509-5] Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–32. doi: 10.1016/S0092-8674(01)00483-4 . PMID 11551509. S2CID 14119088.

[entrez-6] "Entrez Gene: MRGPRX1 MAS-related GPR, member X1".

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MRGPRX1

Contents

See also

Related Research Articles

References

Further reading