The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A2b receptor gene which encodes it. [5]
This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.
The gene is located near the Smith-Magenis syndrome region on chromosome 17. [5]
Research into selective A2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A2B-selective compounds have now been developed, [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] and research into their potential therapeutic applications is ongoing. [16] [17] [18] [19] [20] [21] [22]