Hydroxycarboxylic acid receptor 3

Last updated

HCAR3
Identifiers
Aliases HCAR3 , GPR109B, HCA3, HM74, PUMAG, Puma-g, Niacin receptor 2, hydroxycarboxylic acid receptor 3
External IDs OMIM: 606039; MGI: 1933383; HomoloGene: 130547; GeneCards: HCAR3; OMA:HCAR3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006018

NM_030701

RefSeq (protein)

NP_006009

NP_109626

Location (UCSC) Chr 12: 122.71 – 122.72 Mb Chr 5: 124 – 124 Mb
PubMed search [3] [4]
Wikidata
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Hydroxycarboxylic acid receptor 3 (HCA3), also known as niacin receptor 2 (NIACR2) and GPR109B, [5] is a protein which in humans is encoded by the HCAR3 gene. [6] [7] HCA3, like the other hydroxycarboxylic acid receptors HCA1 and HCA2, is a Gi/o-coupled G protein-coupled receptor (GPCR). [5] [8] The primary endogenous agonists of HCA3 are 3-hydroxyoctanoic acid and kynurenic acid. [5] [8] [9] HCA3 is also a low-affinity biomolecular target for niacin (aka nicotinic acid). [10]

Contents

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000255398 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045502 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (June 2011). "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)". Pharmacological Reviews. 63 (2): 269–290. doi: 10.1124/pr.110.003301 . PMID   21454438.
  6. "Entrez Gene: GPR109B G protein-coupled receptor 109B".
  7. Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology. 5 (10): 1239–1249. doi:10.1093/intimm/5.10.1239. PMID   7505609.
  8. 1 2 Offermanns S, Colletti SL, IJzerman AP, Lovenberg TW, Semple G, Wise A, et al. "Hydroxycarboxylic acid receptors". IUPHAR/BPS Guide to Pharmacology. International Union of Basic and Clinical Pharmacology. Retrieved 13 July 2018.
  9. Kapolka NJ, Taghon GJ, Rowe JB, Morgan WM, Enten JF, Lambert NA, et al. (June 2020). "DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery". Proceedings of the National Academy of Sciences of the United States of America. 117 (23): 13117–13126. Bibcode:2020PNAS..11713117K. doi: 10.1073/pnas.2000430117 . PMC   7293659 . PMID   32434907.
  10. Peters A, Krumbholz P, Jäger E, Heintz-Buschart A, Çakir MV, Rothemund S, et al. (May 2019). "Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3". PLoS Genetics. 15 (5): e1008145. doi: 10.1371/journal.pgen.1008145 . PMC   6532841 . PMID   31120900.

Further reading