GPR112

Last updated

ADGRG4
Identifiers
Aliases ADGRG4 , PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4
External IDs MGI: 2685213; HomoloGene: 72131; GeneCards: ADGRG4; OMA:ADGRG4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

139378

236798

Ensembl

ENSG00000156920

ENSMUSG00000053852

UniProt

Q8IZF6

n/a

RefSeq (mRNA)

NM_153834

NM_001033327
NM_001110790
NM_001362885

RefSeq (protein)

NP_722576

n/a

Location (UCSC) Chr X: 136.3 – 136.42 Mb Chr X: 55.92 – 56.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. [5] [6] GPR112 is a member of the adhesion GPCR family. [7] [8] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [9]

GPR112 is expressed in human enterochromaffin cells [10] and in the mouse intestine. [11] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules. [11] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells. [10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000156920 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053852 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: GPR112 G protein-coupled receptor 112".
  6. ↑ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC   4394687 . PMID   25713288.
  7. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN   978-1-4419-7912-4.
  8. ↑ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID   23695165. S2CID   6958640.
  9. ↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC   3321182 . PMID   22333914.
  10. 1 2 Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, et al. (February 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology. 22 (2): 261–272. doi: 10.1038/modpathol.2008.174 . PMID   18953328. S2CID   22334557.
  11. 1 2 Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC   4394687 . PMID   25713288.
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