GPR161

GPR161
Identifiers
Aliases	GPR161 , RE2, G protein-coupled receptor 161
External IDs	OMIM: 612250; MGI: 2685054; HomoloGene: 17824; GeneCards: GPR161; OMA:GPR161 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q24.2 Start 168,079,542 bp [1] End 168,137,667 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H2.2|1 72.64 cM Start 165,123,358 bp [2] End 165,154,314 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence myometrium buccal mucosa cell ventricular zone tail of epididymis body of uterus pars reticulata stromal cell of endometrium spinal ganglia pars compacta Top expressed in subiculum otic vesicle Region I of hippocampus proper ganglionic eminence hand lumbar spinal ganglion morula medial ganglionic eminence hippocampus proper ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity Cellular component plasma membrane cell projection membrane ciliary membrane integral component of membrane endocytic vesicle membrane cilium recycling endosome Biological process multicellular organism development signal transduction G protein-coupled receptor signaling pathway negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23432 240888 Ensembl ENSG00000143147 ENSMUSG00000040836 UniProt Q8N6U8 B2RPY5 RefSeq (mRNA) NM_001267609 NM_001267610 NM_001267611 NM_001267612 NM_001267613 NM_001267614 NM_007369 NM_153832 NM_001349632 NM_001349633 NM_001349634 NM_001349635 NM_001375883 NM_001375884 NM_001375885 NM_001381909 NM_001081126 NM_001310429 NM_001310430 RefSeq (protein) NP_001254538 NP_001254539 NP_001254540 NP_001254541 NP_001254542 NP_001254543 NP_722561 NP_001336561 NP_001336562 NP_001336563 NP_001336564 NP_001362812 NP_001362813 NP_001362814 NP_001368838 NP_001074595 NP_001297358 NP_001297359 Location (UCSC) Chr 1: 168.08 – 168.14 Mb Chr 1: 165.12 – 165.15 Mb PubMed search [3] [4]
Wikidata
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G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene. ^{[5] [6]} It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation. ^{[7] [8] [9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000143147 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040836 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Small KM, Seman CA, Castator A, Brown KM, Liggett SB (Apr 2002). "False positive non-synonymous polymorphisms of G-protein coupled receptor genes". FEBS Letters. 516 (1–3): 253–256. Bibcode:2002FEBSL.516..253S. doi:10.1016/S0014-5793(02)02564-4. PMID   11959142. S2CID   35944696.
6. "Entrez Gene: GPR161 G protein-coupled receptor 161".
7. Tschaikner P, Enzler F, Torres-Quesada O, Aanstad P, Stefan E (2020). "Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium". Cells. 9 (1): 118. doi: 10.3390/cells9010118 . PMC   7017137 . PMID   31947770.
8. Patel K, Smith NJ (2024). "Primary cilia, A-kinase anchoring proteins and constitutive activity at the orphan G protein-coupled receptor GPR161: A tale about a tail". British Journal of Pharmacology. 181 (14): 2182–2196. doi:10.1111/bph.16053. PMID   36772847.
9. Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, et al. (2024). "GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway". Nature Structural & Molecular Biology. 31 (4): 667–677. doi:10.1038/s41594-024-01223-8. PMC   11221913 . PMID   38326651.
10. Paillard T, Allam A, Doulazmi M, Hautefeuille M, Fouquet C, Sarde L, et al. (2025). "GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration". Science Advances. 11 (31) eadx3846: eadx3846. doi:10.1126/sciadv.adx3846. PMC   12309678 . PMID   40737401.

Further reading

• Schöneberg T, Schulz A, Gudermann T (2002). "The structural basis of G-protein-coupled receptor function and dysfunction in human diseases". Reviews of Physiology, Biochemistry and Pharmacology. Vol. 144. pp. 143–227. doi:10.1007/BFb0116587. ISBN   978-3-540-42814-5. PMID   11987825.
• Raming K, Konzelmann S, Breer H (1999). "Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone". Receptors & Channels. 6 (2): 141–151. PMID   9932290.