CELSR3

CELSR3
Identifiers
Aliases	CELSR3 , CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3
External IDs	OMIM: 604264 MGI: 1858236 HomoloGene: 1077 GeneCards: CELSR3
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 48,636,463 bp [1] End 48,662,886 bp [1]
Gene ontology Molecular function • calcium ion binding • G protein-coupled receptor activity • signal transducer activity • GO:0001948 protein binding • transmembrane signaling receptor activity Cellular component • integral component of membrane • membrane • plasma membrane Biological process • regulation of protein phosphorylation • dopaminergic neuron axon guidance • G protein-coupled receptor signaling pathway • serotonergic neuron axon guidance • neuron migration • regulation of protein localization • multicellular organism development • Wnt signaling pathway, planar cell polarity pathway • cell surface receptor signaling pathway • cell adhesion • axonal fasciculation • signal transduction • homophilic cell adhesion via plasma membrane adhesion molecules • planar cell polarity pathway involved in axon guidance • cilium assembly • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1951	107934
Ensembl	ENSG00000008300	ENSMUSG00000023473
UniProt	Q9NYQ7	Q91ZI0
RefSeq (mRNA)	NM_001407	NM_080437
RefSeq (protein)	NP_001398	NP_536685 NP_001346501 NP_001346502
Location (UCSC)	Chr 3: 48.64 – 48.66 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene. ^{[4] [5]}

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. ^[5]

See also

• Flamingo (protein)

References

1. GRCh38: Ensembl release 89: ENSG00000008300 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID   9693030.
5. "Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi: 10.1016/S0092-8674(00)80789-8 . PMID   10380929. S2CID   6014717.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi: 10.1073/pnas.060027397 . PMC   16203 . PMID   10716726.
• Formstone CJ, Barclay J, Rees M, Little PF (2000). "Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9". Mamm. Genome. 11 (5): 392–4. doi:10.1007/s003350010073. PMID   10790539. S2CID   21333332.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID   15203201.

External links

• Human CELSR3 genome location and CELSR3 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.