TAS2R31

Last updated
TAS2R31
Identifiers
Aliases TAS2R31 , T2R31, T2R44, T2R53, TAS2R44, taste 2 receptor member 31
External IDs OMIM: 612669 MGI: 2681304 HomoloGene: 136304 GeneCards: TAS2R31
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_176885

NM_181276

RefSeq (protein)

NP_795366

NP_851793

Location (UCSC) Chr 12: 11.03 – 11.03 Mb Chr 6: 132.78 – 132.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Taste receptor, type 2, member 31, also known as TAS2R31, is a protein which in humans is encoded by the TAS2R31 gene. [5] This bitter taste receptor has been shown to respond to saccharin in vitro. [6]

Contents

TAS2R31 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation. [7]

Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium. [8]

See also

Related Research Articles

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TAS2R16

TAS2R16 is a human gene that encodes for a receptor that may play a role in the perception of bitterness.

TAS2R38

Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the few taste receptors shown to have this function.

TAS2R9

Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.

TAS2R10

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.

TAS2R14

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.

TAS1R2

Taste receptor type 1 member 2 is a protein that in humans is encoded by the TAS1R2 gene.

TAS1R3

Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene. The TAS1R3 gene encodes the human homolog of mouse Sac taste receptor, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.

TAS2R39

Taste receptor type 2 member 39 is a protein that in humans is encoded by the TAS2R39 gene.

TAS2R40

Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene.

TAS2R41

Taste receptor type 2 member 41 is a protein that in humans is encoded by the TAS2R41 gene.

TAS2R43

Taste receptor type 2 member 43 is a protein that in humans is encoded by the TAS2R43 gene.

TAS2R45

Taste receptor type 2 member 45 is a protein that in humans is encoded by the TAS2R45 gene.

TAS2R46

Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene.

TAS2R30 Protein-coding gene in humans

Taste receptor type 2 member 30 is a protein that in humans is encoded by the TAS2R30 gene.

TAS2R19

Taste receptor type 2 member 19 is a protein that in humans is encoded by the TAS2R19 gene. It seems to be involved in the perception of salt and bitter tastes.

TAS2R20

Taste receptor type 2 member 20 is a protein that in humans is encoded by the TAS2R20 gene.

TAS2R50

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.

TAS2R60

Taste receptor type 2 member 60 is a protein that in humans is encoded by the TAS2R60 gene.

References

  1. 1 2 3 ENSG00000263097, ENSG00000282256 GRCh38: Ensembl release 89: ENSG00000256436, ENSG00000263097, ENSG00000282256 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053217 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: TAS2R31 taste receptor, type 2, member 31".
  6. Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W (November 2004). "Bitter taste receptors for saccharin and acesulfame K". J. Neurosci. 24 (45): 10260–5. doi:10.1523/JNEUROSCI.1225-04.2004. PMC   6730199 . PMID   15537898.
  7. Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med. 16 (11): 1299–304. doi:10.1038/nm.2237. PMC   3066567 . PMID   20972434.
  8. Allen AL, McGeary JE, Knopik VS, Hayes JE (2013). "Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31". Chem. Senses. 38 (5): 379–89. doi:10.1093/chemse/bjt017. PMC   3657735 . PMID   23599216.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.